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Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome.

Abstract：

:We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain retroelements. In addition, there were differential increments in the genome size of the liver with increasing age, which peaked at 5 weeks. The findings that the genome structure of an individual is variable depending on age and organ type in association with the transposition of retroelements may have broad implications in understanding biologic phenomena.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Lee KH,Chiu S,Lee YK,Greenhalgh DG,Cho K

doi

10.1016/j.yexmp.2012.04.013

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

167-72

issue

1

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(12)00058-5

journal_volume

93

pub_type

杂志文章

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