Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells.

abstract：:Spiroplasma spp. are important phyto and insect pathogens, and candidate causal agent/s of transmissible spongiform encephalopathies (TSE) in man and animals. These filterable wall-less bacteria are widely distributed in nature with an unspecified environmental reservoir. In this study we showed by scanning electron m...

journal_title：Experimental and molecular pathology

authors： Bastian FO,Elzer PH,Wu X

更新日期：2012-08-01 00:00:00

abstract：:One of the main mechanisms for multidrug resistance (MDR) involves multidrug resistance gene 1 (MDR1) which encodes P-glycoprotein (Pgp). Pgp acts as a drug efflux pump and exports chemotherapeutic agents from cancer cells. Specific inhibition of Pgp expression by gene therapy is considered a well-respective strategy ...

journal_title：Experimental and molecular pathology

authors： Xing AY,Shi DB,Liu W,Chen X,Sun YL,Wang X,Zhang JP,Gao P

更新日期：2013-06-01 00:00:00

abstract：:A novel intrauterine transplantation (IUT) approach was developed to improve the efficiency of engraftment of hematopoietic stem cells (HSCs). HSCs with a green fluorescent protein (GFP) reporter gene were transplanted in utero on days 12.5, 13.5 and 14.5 post coitum (p.c.). The degree of chimerism of donor cells in r...

journal_title：Experimental and molecular pathology

authors： Chen X,Gong XL,Katsumata M,Zeng YT,Huang SZ,Zeng F

更新日期：2009-12-01 00:00:00

abstract：:The present study was addressed to understand two specific issues: (a) whether atherogenic activity of smooth muscle cells could be initiated by incorporating cholesterol within their membranes through a LDL-receptor-independent pathway; and (b) whether trifluoperazine, which we had recently shown to prevent the chole...

journal_title：Experimental and molecular pathology

authors： Mehta U,Kaul D

更新日期：1991-08-01 00:00:00

abstract：:Several laboratories have recently reported on the structural and functional characteristics of an LDL fraction isolated from atherosclerotic lesions, designated A-LDL. Given the wide variety of tissue sources and isolation conditions that have been employed, we have addressed whether several procedures currently used...

journal_title：Experimental and molecular pathology

authors： Hoff HF,O'Neil J,Cole TB

更新日期：1991-02-01 00:00:00

abstract：:The purpose of the study was to determine the temporal relationship between lymphocyte activating factor (LAF) activity and the acute-phase response, as measured by plasma fibronectin (Fn), C-reactive protein (CRP), and albumin levels in adjuvant arthritic rats. LAF activity as measured in the thymocyte costimulator a...

journal_title：Experimental and molecular pathology

authors： Connolly KM,Stecher VJ,Allin S,LaBrie T

更新日期：1988-12-01 00:00:00

abstract：:Huntingtin-interacting protein 1-related (HIP1R) is an endocytic protein involved in receptor trafficking, including regulating cell surface expression of receptor tyrosine kinases. We have previously shown that low HIP1R protein expression was associated with poorer survival in diffuse large B-cell lymphoma (DLBCL) p...

journal_title：Experimental and molecular pathology

authors： Wong KK,Ch'ng ES,Loo SK,Husin A,Muruzabal MA,Møller MB,Pedersen LM,Pomposo MP,Gaafar A,Banham AH,Green TM,Lawrie CH

更新日期：2015-12-01 00:00:00

abstract：:In a previous study the authors demonstrated monotypic foci, all of timidus type, in the atherosclerotic lesions and normal aortic tissue of glucose-6-phosphate dehydrogenase (G-6-PD) mosaic hares fed 25-hydroxycholesterol or triol in addition to a high-cholesterol diet. Other hares fed the high-cholesterol diet witho...

journal_title：Experimental and molecular pathology

authors： Lee KT,Janakidevi K,Kroms M,Schmee J,Thomas WA

更新日期：1985-02-01 00:00:00

abstract：:The most common recurrent translocation in clear cell sarcoma t(12;22)(q13;q12) results in an EWSR1/ATF1 chimeric gene. We present a molecular analysis of tumor overgrowing right proximal tibia with bone destruction metastatic to two groin lymph nodes. Fluorescent in situ hybridization analysis performed on paraffin-e...

journal_title：Experimental and molecular pathology

authors： Jakubauskas A,Valceckiene V,Andrekute K,Seinin D,Kanopka A,Griskevicius L

更新日期：2011-04-01 00:00:00

abstract：:Whatman FTA® cards provide the most reliable method for DNA storage and extraction, however, the literature lacks reports on the epigenetic analysis of FTA card-derived tumor DNA. Therefore, this study aimed at demonstrating that punches from colonic adenoma samples preserved on FTA filter cards are suitable for methy...

journal_title：Experimental and molecular pathology

authors： Buxhofer-Ausch V,Ausch C,Reiner A,Müllner-Ammer K,Schmid A,Kriwanek S,Sebesta C,Halwachs-Baumann G,Kriegshäuser G

更新日期：2020-06-01 00:00:00

abstract：:Several growth factors are actively synthesized during wound repair and function to stimulate different cell types involved in the process of healing. Fibrosin is a novel fibrogenic lymphokine that stimulates several biological activities that relate to in vivo scarring. To investigate the role of fibrosin, we used "p...

journal_title：Experimental and molecular pathology

authors： Prakash S,Robbins PW

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the role and regulatory mechanisms of Akt/TSC1-TSC2/mTOR signal pathway on the hepatocyte growth and proliferation after partial hepatectomy in rats. METHODS:We used the animal model of 70% hepatectomy, separated and cultivated hepatocytes. According to the different ...

journal_title：Experimental and molecular pathology

authors： Chen P,Yan H,Chen Y,He Z

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Calcific tendinopathy (CT) is characterized by deposits of calcium, most commonly found in the shoulder tendons. The exact cause and pathogenesis of CT are not fully understood. This study analyzed the expression pattern of RNA-binding protein fox-1 homolog 2 (RBFOX2), a crucial splicing regulator in tissue ...

journal_title：Experimental and molecular pathology

authors： Cho N,Kim JO,Lee S,Choi S,Kim J,Ko MS,Park SJ,Ji JH,Kim KK

更新日期：2019-08-01 00:00:00

abstract：:Piecemeal necrosis, currently called interface hepatitis, is a feature of viral hepatitis as well as autoimmune hepatitis and steatohepatitis. The mechanism of liver cell loss and piecemeal necrosis needs to be determined. We hypothesize that piecemeal necrosis in hepatitis is due to a piecemeal removal of hepatocyte ...

journal_title：Experimental and molecular pathology

authors： Wang MX,Morgan T,Lungo W,Wang L,Sze GZ,French SW

更新日期：2001-10-01 00:00:00

abstract：:There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins cou...

journal_title：Experimental and molecular pathology

authors： French SW,Mendoza AS,Peng Y

更新日期：2016-06-01 00:00:00

abstract：:Recently it was observed that the hypothyroid state induced by propylthiouracil treatment reduced the elimination rate of ethanol. This was based on the fact that hypothyroid rats could only tolerate 10 g/kg/day of ethanol infusion over 24 h. Euthyroid rats tolerate 13 to 14 g/kg/day of ethanol infusion. In the presen...

journal_title：Experimental and molecular pathology

authors： Li J,French BA,Fu P,French SW

更新日期：2001-08-01 00:00:00

abstract：:Ketamine, a common N-methyl-d-aspartate receptor (NMDAR) antagonist, is an option for cancer pain treatment in clinical practice. Ketamine has been shown to have the capacity to attenuate cancer cells malignancy. However, the underlying mechanism remains elusive. In the present study, we reported that ketamine inhibit...

journal_title：Experimental and molecular pathology

authors： Duan W,Hu J,Liu Y

更新日期：2019-04-01 00:00:00

abstract：:Mononuclear cell infiltration of the thyroid is a prominent feature of chronic lymphocytic thyroiditis. Adhesion molecules play a major role in determining the localization of inflammatory mononuclear cells in the thyroid. Previous reports from animal models and human studies have described the thyroidal expression of...

journal_title：Experimental and molecular pathology

authors： Bonita RE,Rose NR,Rasooly L,Caturegli P,Burek CL

更新日期：2002-12-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is a clinical syndrome that is characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or noninfectious insult. In this report we describe a unique animal model in which CBA/J ...

journal_title：Experimental and molecular pathology

authors： London L,Majeski EI,Paintlia MK,Harley RA,London SD

更新日期：2002-02-01 00:00:00

abstract：:A primary culture of cells derived from uninvolved and atherosclerotic intima of human aorta was used to elucidate the role of cyclic nucleotides in atherogenesis. The cells cultured from fatty streaks and atherosclerotic plaques had a 2- to 8-fold lower cyclic AMP level and a 1.5- to 2-fold higher level of cyclic GMP...

journal_title：Experimental and molecular pathology

authors： Tertov VV,Orekhov AN,Kudryashov SA,Klibanov AL,Ivanov NN,Torchilin VP,Smirnov VN

更新日期：1987-12-01 00:00:00

abstract：:The present study was aimed at clarifying the effects of an anti-apoptotic protein for modulating symptoms in acute lung injury (ALI). From Bcl-x(L), a Bcl-2 family member, we constructed an artificial protein (FNK) and fused it with the protein transduction domain (PTD) of the HIV/Tat protein (PTD-FNK) to facilitate ...

journal_title：Experimental and molecular pathology

authors： Chen H,Zhang L,Jin Z,Jin E,Fujiwara M,Ghazizadeh M,Asoh S,Ohta S,Kawanami O

更新日期：2007-12-01 00:00:00

abstract：:Myocardial ischemia-reperfusion (I/R) injury severely impacts the postoperative survival rate of coronary atherosclerotic heart disease. Radioprotective 105 kDa protein (RP105) is a regulator of Toll-like receptor 4 (TLR4), an inflammatory factor whose functions have been reported in myocardial I/R injury. To investig...

journal_title：Experimental and molecular pathology

authors： Li X,Yang J,Yang J,Dong W,Li S,Wu H,Li L

更新日期：2016-04-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrial counties. Its pathogenesis is at least partially mediated by immunological factors, including a possible autoimmune response. To date, only a few antibodies have been identified in sera from patients with AMD. In order ...

journal_title：Experimental and molecular pathology

authors： Morohoshi K,Patel N,Ohbayashi M,Chong V,Grossniklaus HE,Bird AC,Ono SJ

更新日期：2012-02-01 00:00:00

abstract：:Drug-primed mice form Mallory bodies in their liver after various types of liver injury such as heat shock, drug refeeding, or ethanol ingestion. However, the mechanisms involved that lead to Mallory body formation after these different treatments are unknown. There may be a common pathway of Mallory body formation th...

journal_title：Experimental and molecular pathology

authors： Yuan QX,Nagao Y,Gaal K,Hu B,French SW

更新日期：1998-10-01 00:00:00

abstract：:Plasmablastic lymphoma (PBL) is an uncommon aggressive lymphoma arising most frequently in the oral cavity of HIV-infected patients. Rare cases of PBL have been reported in extraoral sites, particularly extranodal sites, as well as in immunocompetent patients. We report an unusual case of PBL in a 69-year-old, HIV-neg...

journal_title：Experimental and molecular pathology

authors： Qing X,Sun N,Chang E,French S,Ji P,Yue C

更新日期：2011-02-01 00:00:00

abstract：:It is well-known that leukemic cells of overt leukemia (OL) that have transformed from myelodysplastic syndromes (MDS) are more resistant to chemotherapy as compared with de novo AML cells. Thus, to examine the expression levels of drug-resistant genes and their alterations with the development of OL in MDS, the expre...

journal_title：Experimental and molecular pathology

authors： Kurata M,Hasegawa M,Nakagawa Y,Abe S,Yamamoto K,Suzuki K,Kitagawa M

更新日期：2006-12-01 00:00:00

abstract：:Invadopodia, cancer cell protrusions with proteolytic activity, are functionally associated with active remodeling of the extracellular matrix. Here, we show that the invadopodia-related protein TKS5 is expressed in human pancreatic adenocarcinoma lines, and demonstrate that pancreatic cancer cells depend on TKS5 for ...

journal_title：Experimental and molecular pathology

authors： Chen YC,Baik M,Byers JT,Chen KT,French SW,Díaz B

更新日期：2019-02-01 00:00:00

abstract：:Retinoblastoma (RB), the most common intra-ocular malignancy in children under 5 years of age, has an estimated incidence of about 2000 a year in India, where most cases are in advanced stage at the time of diagnosis. Newer therapeutic approaches would reduce the morbidity of chemotherapy in children with RB. Fatty Ac...

journal_title：Experimental and molecular pathology

authors： Vandhana S,Deepa PR,Jayanthi U,Biswas J,Krishnakumar S

更新日期：2011-02-01 00:00:00

abstract：:Viral pathogens have been implicated in the development of certain cancers including human papillomavirus (HPV) in squamous cell carcinoma and Epstein-Barr virus (EBV) in Burkitt's lymphoma. The significance of viral pathogens in brain tumors is controversial, and human cytomegalovirus (HCMV) has been associated with ...

journal_title：Experimental and molecular pathology

authors： Cimino PJ,Zhao G,Wang D,Sehn JK,Lewis JS Jr,Duncavage EJ

更新日期：2014-06-01 00:00:00

abstract：:Certain biochemical parameters of acute liver injury induced by carbon tetrachloride were investigated in rats treated with prostacyclin (PGI2) and two of its derivatives. Serum glutamate oxalacetate transaminase elevation and both triglyceride accumulation and reduction of glycogen content in liver were significantly...

journal_title：Experimental and molecular pathology

authors： Divald A,Ujhelyi E,Jeney A,Lapis K,Institoris L

更新日期：1985-04-01 00:00:00