Alteration of tryptophan-mediated regulation in Neurospora crassa by indoleglycerol phosphate.

Abstract:

:The accumulation of imidazoleglycerol phosphate during growth of Neurospora crassa in the presence of 3-amino-1,2,4-triazole was found to cause derepression of tryptophan synthetase and to inhibit the induction of kynureninase. Accumulation of indoleglycerol phosphate in response to growth in the presence of indole acrylic acid or anthranilic acid was also accompanied by derepressed synthesis of tryptophan synthetase. Enzyme synthesis in mutants (his-7 and trp-4) unable to form these intermediates was not altered under similar conditions. The rate of formation of tryptophan synthetase and kynureninase was found to differ in the presence of tryptophan and indole.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Turner JR,Matchett WH

doi

10.1128/JB.95.5.1608-1614.1968

subject

Has Abstract

pub_date

1968-05-01 00:00:00

pages

1608-14

issue

5

eissn

0021-9193

issn

1098-5530

journal_volume

95

pub_type

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