Characterization of a highly structured domain in Tbp2 from Neisseria meningitidis involved in binding to human transferrin.

Abstract:

:The binding of iron-loaded human transferrin at the surface of Neisseria meningitidis is mediated by two polypeptides, Tbp1 and Tbp2. Predicted Tbp amino acid sequences from N. meningitidis strains are highly divergent. This variability is particularly pronounced throughout the Tbp2 polypeptide. In this study, a highly structured and extremely stable Tbp2 domain of about 270 to 290 amino acids which is involved in the binding to transferrin and whose position is well conserved has been characterized. The conservation of such a remarkable structure in a very divergent protein domain (there is only 43% amino acid identity within this region) suggests that is plays an essential biological role and raises a number of questions regarding tbp2 evolution.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Vonder Haar RA,Legrain M,Kolbe HV,Jacobs E

doi

10.1128/jb.176.20.6207-6213.1994

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

6207-13

issue

20

eissn

0021-9193

issn

1098-5530

journal_volume

176

pub_type

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