Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes.

Abstract:

:lisRK encodes a two-component regulatory system in the food pathogen Listeria monocytogenes LO28. Following identification of the operon in an acid-tolerant Tn917 mutant, a deletion in the histidine kinase component was shown to result in a growth phase variation in acid tolerance, an ability to grow in high ethanol concentrations, and a significant reduction in virulence.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Cotter PD,Emerson N,Gahan CG,Hill C

doi

10.1128/JB.181.21.6840-6843.1999

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

6840-3

issue

21

eissn

0021-9193

issn

1098-5530

journal_volume

181

pub_type

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