PHAGOCYTOSIS INHIBITION AND REVERSAL. I. EFFECT OF GLYCOLYTIC INTERMEDIATES AND NUCLEOTIDES ON PARTICLE UPTAKE.

Abstract:

:Sbarra, Anthony J. (St. Margaret's Hospital, Boston, Mass.) and William Shirley. Phagocytosis inhibition and reversal. I. Effect of glycolytic intermediates and nucleotides on particle uptake. J. Bacteriol. 86:259-265. 1963.-By microscopically monitoring phagocytosis and following the biochemical changes associated with this process, the inhibition of phagocytosis by fluoride or iodoacetate was shown to be partially reversed by pyruvate. This reversal occurred with both inhibitors, either aerobically or anaerobically. Nicotinamide adenine dinucleotide (NAD) apparently increased the degree of pyruvate reversal when fluoride, but not iodoacetate, was the inhibitory agent. Lactate under some conditions was also shown to reverse the inhibition. It is suggested that pyruvate and NAD are key compounds for the phagocytic process.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

SBARRA AJ,SHIRLEY W

doi

10.1128/JB.86.2.259-265.1963

keywords:

subject

Has Abstract

pub_date

1963-08-01 00:00:00

pages

259-65

eissn

0021-9193

issn

1098-5530

journal_volume

86

pub_type

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