Temporal global changes in gene expression during temperature transition in Yersinia pestis.

Abstract:

:DNA microarrays encompassing the entire genome of Yersinia pestis were used to characterize global regulatory changes during steady-state vegetative growth occurring after shift from 26 to 37 degrees C in the presence and absence of Ca2+. Transcriptional profiles revealed that 51, 4, and 13 respective genes and open reading frames (ORFs) on pCD, pPCP, and pMT were thermoinduced and that the majority of these genes carried by pCD were downregulated by Ca2+. In contrast, Ca2+ had little effect on chromosomal genes and ORFs, of which 235 were thermally upregulated and 274 were thermally downregulated. The primary consequence of these regulatory events is profligate catabolism of numerous metabolites available in the mammalian host.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Motin VL,Georgescu AM,Fitch JP,Gu PP,Nelson DO,Mabery SL,Garnham JB,Sokhansanj BA,Ott LL,Coleman MA,Elliott JM,Kegelmeyer LM,Wyrobek AJ,Slezak TR,Brubaker RR,Garcia E

doi

10.1128/JB.186.18.6298-6305.2004

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

6298-305

issue

18

eissn

0021-9193

issn

1098-5530

pii

186/18/6298

journal_volume

186

pub_type

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