Abstract:
:DNA microarrays encompassing the entire genome of Yersinia pestis were used to characterize global regulatory changes during steady-state vegetative growth occurring after shift from 26 to 37 degrees C in the presence and absence of Ca2+. Transcriptional profiles revealed that 51, 4, and 13 respective genes and open reading frames (ORFs) on pCD, pPCP, and pMT were thermoinduced and that the majority of these genes carried by pCD were downregulated by Ca2+. In contrast, Ca2+ had little effect on chromosomal genes and ORFs, of which 235 were thermally upregulated and 274 were thermally downregulated. The primary consequence of these regulatory events is profligate catabolism of numerous metabolites available in the mammalian host.
journal_name
J Bacterioljournal_title
Journal of bacteriologyauthors
Motin VL,Georgescu AM,Fitch JP,Gu PP,Nelson DO,Mabery SL,Garnham JB,Sokhansanj BA,Ott LL,Coleman MA,Elliott JM,Kegelmeyer LM,Wyrobek AJ,Slezak TR,Brubaker RR,Garcia Edoi
10.1128/JB.186.18.6298-6305.2004keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
6298-305issue
18eissn
0021-9193issn
1098-5530pii
186/18/6298journal_volume
186pub_type
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journal_title:Journal of bacteriology
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更新日期:1967-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1978-08-01 00:00:00
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1978-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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更新日期:1997-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1971-01-01 00:00:00
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journal_title:Journal of bacteriology
pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00
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journal_title:Journal of bacteriology
pub_type: 杂志文章
doi:10.1128/JB.127.1.367-379.1976
更新日期:1976-07-01 00:00:00
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journal_title:Journal of bacteriology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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journal_title:Journal of bacteriology
pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00