Abstract:
:Streptomyces globisporus produced an enzyme which had lytic effects on streptococci and was able to solubilize their Fc-receptors. A new method for rapid purification of this enzyme was described. It consisted of adsorption to Amberlite CG 50 and subsequent chromatography on CM-cellulose Whatman CM 52. The purified enzyme was free of proteases and had lysed streptococci of serological groups A, B, C, G and L. It released Fc-receptors from the streptococcal surface in a biologically active form.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Tille D,Chhatwal GS,Blobel Hdoi
10.1007/BF02123127subject
Has Abstractpub_date
1986-01-01 00:00:00pages
35-41issue
1eissn
0300-8584issn
1432-1831journal_volume
175pub_type
杂志文章abstract::The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B(2) (B(2)R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B(2)R (B(2)R(-/-) mice) were sh...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-008-0103-4
更新日期:2009-02-01 00:00:00
abstract::When P3HR-1 lymphoblastoid cells expressing Epstein-Barr virus (EBV)-related antigens at very low frequency were cocultivated with human umbilical cord blood lymphocytes and the cell-free mixed culture fluid was applied to fresh cord lymphocytes, cells morphologically distinct from normal lymphocytes became evident af...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02125494
更新日期:1978-01-01 00:00:00
abstract::A skim-milk fraction and a whey-protein concentrate (WPC) fraction were prepared from the cows that had been immunized with E. coli isolated from the mouse intestine. The antibacterial effect of these fractions against E. coli was examined. They contained antibody with a high affinity for E. coli strain 48, a represen...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00189427
更新日期:1992-01-01 00:00:00
abstract::The antiviral activity of mouse fibroblast interferon against vesicular stomatitis virus was investigated in L-929 mouse fibroblasts and the ganglioside-deficient L-929 mutant cells (ATCC clone NCTC 2071). Although it has been widely reported that gangliosides serve as primary receptors for interferon at the cellular ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02125527
更新日期:1981-01-01 00:00:00
abstract::Various strains of Helicobacter pylori were able to lyse erythrocytes from sheep, horse, and human when grown on blood agar. The hemolysis did not depend on the production of the vacuolating cytotoxin VacA as demonstrated by the hemolytic behavior of an isogenic vacA-negative mutant strain. The hemolytic activity coul...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s004300050062
更新日期:1998-03-01 00:00:00
abstract::Low public awareness of cytomegalovirus (CMV) results from the only mild and transient symptoms that it causes in the healthy immunocompetent host, so that primary infection usually goes unnoticed. The virus is not cleared, however, but stays for the lifetime of the host in a non-infectious, replicatively dormant stat...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-012-0273-y
更新日期:2012-11-01 00:00:00
abstract::Cytomegalovirus vaccine development started in the 1970s with attenuated strains. In the 1980s, one of the strains was shown to be safe and effective in renal transplant patients. Then, attention switched to glycoprotein gB, which was shown to give moderate but transient protection against acquisition of the virus by ...
journal_title:Medical microbiology and immunology
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00430-015-0388-z
更新日期:2015-06-01 00:00:00
abstract::In resource-limited or point-of-care settings, rapid diagnostic tests (RDTs), that aim to simultaneously detect HIV antibodies and p24 capsid (p24CA) antigen with high sensitivity, can pose important alternatives to screen for early infections. We evaluated the performance of the antibody and antigen components of the...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-019-00655-0
更新日期:2020-04-01 00:00:00
abstract::Therapeutic vaccination for the treatment of chronic hepatitis B has thus far been unsatisfactory. In this review, we discuss potential new therapeutic vaccination strategies and other immunotherapeutic approaches that aim to achieve efficient restoration of HBV immunity in chronically infected patients. ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-014-0377-7
更新日期:2015-02-01 00:00:00
abstract::9 antigen distribution and sensitivity to the bactericidal effect of normal human serum were determined in 485 Proteus strains isolated from urine, blood, wounds, and feces. Of all strains, 62% could be grouped according to 25 0 antigens. The most frequent one, 0 3, appeared in 13% of all the strains. In blood culture...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02121822
更新日期:1977-07-18 00:00:00
abstract::The structural relation of YOP-1 of "european" and "american" Yersinia enterocolitica serotypes O:3, O:9, O:5,27, and O:8 and O:20, respectively, and Y. pseudotuberculosis serotypes I, II, and III was compared by sodium dodecyl sulfate polyacrylamide gel electrophoresis and peptide mapping using Staphylococcus aureus ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00215249
更新日期:1991-01-01 00:00:00
abstract::The effects of gentamicin on cellular physiology were studied in a total of 9 mammalian cell lines, using the following parameters: cell morphology and viability (cytotoxicity), proliferation, culture medium acidification, lactic acid production, lactate dehydrogenase release, virus susceptibility, and effects on kary...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02120767
更新日期:1975-01-01 00:00:00
abstract::We have studied the incidence of enterotoxigenic and enteropathogenic Escherichia coli strains associated with infant diarrhoeal disease in Galicia (North-west Spain). During a period of 9 months we isolated heat-labile enterotoxin-positive strains in 2.1% of children with diarrhoea examined, whereas the production of...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123802
更新日期:1983-01-01 00:00:00
abstract::Vaccination has proven to be one of the best weapons protecting the mankind against infectious diseases. Along with the huge progress in microbiology, numerous highly efficacious and safe vaccines have been produced by conventional technology (cultivation), by the use of molecular biology (genetic modification), or by...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-014-0346-1
更新日期:2014-12-01 00:00:00
abstract::In this study, we presented the construction of a library of expression clones for the herpes simplex virus type 1 (HSV-1) proteome and subcellular localization map of HSV-1 proteins in living cells using yellow fluorescent protein (YFP) fusion proteins. As a result, 21 proteins showed cytoplasmic or subcytoplasmic lo...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-010-0175-9
更新日期:2011-02-01 00:00:00
abstract::Antibody to recombinant hepatitis C virus (HCV) protein C100 (anti-C100) was measured for a period of 6 months by enzyme immunoassay in nine prospectively followed non A-nonB (NANBH) cases which occurred after cardiac surgery at a hospital in Rio de Janeiro (Brazil). At least seven cases were infected with HCV; four o...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00191549
更新日期:1992-01-01 00:00:00
abstract::The aroB gene from Helicobacter pylori strain P1 was cloned and further characterized by sequence analysis and by functional complementation of the aroB mutation in Escherichia coli. The aroB gene encodes the enzyme 3-dehydroquinate synthase which catalyzes one of the early steps in the shikimate pathway. This pathway...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s004300050054
更新日期:1997-10-01 00:00:00
abstract::A new way of measuring indirect immunofluorescence (IIF) of microscopic bacterial slide preparations by videocamera and an image processing system is presented. This method is compared with the conventional method of reading the slides by eye. The advantages of this new approach are objective reading, greater accuracy...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00193850
更新日期:1991-01-01 00:00:00
abstract::The influenza surveillance in Lower Saxony is based mainly on laboratory investigations, and especially those which involve the isolation of influenza viruses throughout the year. These investigations have provided information on the circulation of influenza viruses and of the antigenic drift during the Hong Kong peri...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123292
更新日期:1979-03-13 00:00:00
abstract::Pertussis Toxin (PTx) is one of the most important virulence factors of Bordetella pertussis, the cause of whooping cough. Therefore, the inactivated toxin is an obligatory constituent of acellular pertussis vaccines. It is described in the literature that both native PTx and recombinant Pertussis Toxin (PTg) activate...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-012-0238-1
更新日期:2012-08-01 00:00:00
abstract::Killer cell immunoglobulin like receptors (KIRs) have a principal role in regulating the effector functions of NK cells, particularly in viral infections. The major ligands for KIRs are human leukocyte antigen (HLA) class I molecules. The aim of this study is to investigate the possible association of KIR genes, their...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-017-0522-1
更新日期:2017-12-01 00:00:00
abstract::Adaptation of Borrelia burgdorferi in the vector and vertebrate host is mediated by mechanisms that regulate differential expression of outer surface lipoproteins (Osps). In this study, real time PCR was applied to quantify tissue-specific expression of four linear plasmid (lp54)-encoded (ospA, zs7.a36, zs7.a66 zs7.a6...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-004-0218-1
更新日期:2005-01-01 00:00:00
abstract::Phosphorylcholine (ChoP) is covalently incorporated into bacterial surface structures, contributing to host mimicry and promoting adhesion to surfaces. Our aims were to determine the frequency of ChoP display among Aggregatibacter actinomycetemcomitans strains, to clarify which surface structures bear ChoP, and whethe...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-018-0554-1
更新日期:2018-11-01 00:00:00
abstract::Mycobacterium avium subsp. paratuberculosis (MAP) has long been implicated as a triggering agent in Crohn's disease (CD). In this study, we investigated the growth/persistence of both M. avium subsp. hominissuis (MAH) and MAP, in macrophages from healthy controls (HC), CD and ulcerative colitis patients. For viability...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-015-0393-2
更新日期:2015-12-01 00:00:00
abstract::Industrial and academic needs for innovation and fundamental research are essential and not widely different. Depending on the industrial setting, research and development (R&D) activities may be more focused on the developmental aspects given the need to ultimately sell useful products. However, one of the biggest di...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-019-00643-4
更新日期:2020-06-01 00:00:00
abstract::A coupled luminescent method (CLM) based on glyceraldehyde-3-phosphate dehydrogenase released from injured target cells was used to evaluate the cytotoxicity of antigen-specific HLA class I-restricted CTLs. In contrast to established methods, CLM does not require the pretreatment of target cells with radioactive or to...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-009-0126-5
更新日期:2009-11-01 00:00:00
abstract::BALB/c male mice infected with the H3 variant of coxsackievirus B3 (CVB3) develop fulminant myocarditis. Age-matched female mice show little myocarditis due to decreased virus receptor expression on cardiac cells. TNFalpha and IL-1beta levels were increased in males by 3 days after infection. IFNgamma levels increased...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-004-0221-6
更新日期:2005-05-01 00:00:00
abstract::Varicella during pregnancy can be associated with severe illnesses for both the mother and her neonate. Varicella pneumonia must be regarded as a medical emergency, since pregnant women are at risk of life-threatening ventilatory compromise and death. After maternal chickenpox in the first and second trimesters, conge...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-006-0032-z
更新日期:2007-06-01 00:00:00
abstract::Upon infection of human T-cell leukemia virus type I (HTLV-I)-carrying human T-cell lines such as MT-4, HTLV-III, a probable etiologic agent of acquired immune deficiency syndrome (AIDS) caused fast and strong cytopathic effects leading ultimately to the death of the cells. Such effects were preceded by the rapid indu...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123869
更新日期:1986-01-01 00:00:00
abstract::Recently we demonstrated that lack of mecA transcription was responsible for the decreased methicillin resistance phenotype of strongly slime-negative Staphylococcus epidermidis phase variants [Mempel M, Feucht H, Ziehbuhr W, Endres M, Laufs R, Grüter L (1994) Antimicrob Agents Chemother 38: 1251-1255]. In the present...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00224346
更新日期:1995-10-01 00:00:00