abstract：:It is known that tetraspanin proteins are involved in many physiological somatic cell mechanisms. Additionally, research has indicated they also have a role in various infectious diseases and cancers. This review focuses on the molecular interactions underlying the tetraspanin web formation in gametes. Primarily, tetr...

journal_title：Medical microbiology and immunology

authors： Jankovičová J,Neuerová Z,Sečová P,Bartóková M,Bubeníčková F,Komrsková K,Postlerová P,Antalíková J

更新日期：2020-08-01 00:00:00

abstract：:Tetraspanin (TSPAN) protein family forms a family of transmembrane proteins that act as organizers/scaffold for other proteins. TSPANs are primarily present on plasma membranes although they are also found in other biological membranes. They are organized in tetraspanin-enriched microdomains (TEMs), which allow spatio...

journal_title：Medical microbiology and immunology

authors： Perot BP,Ménager MM

更新日期：2020-08-01 00:00:00

abstract：:Industrial and academic needs for innovation and fundamental research are essential and not widely different. Depending on the industrial setting, research and development (R&D) activities may be more focused on the developmental aspects given the need to ultimately sell useful products. However, one of the biggest di...

journal_title：Medical microbiology and immunology

authors： van Belkum A,Pelegrin AC,Datar R,Goyal M,Palmieri M,Mirande C,Chalansonnet V,Orenga S

更新日期：2020-06-01 00:00:00

abstract：:In resource-limited or point-of-care settings, rapid diagnostic tests (RDTs), that aim to simultaneously detect HIV antibodies and p24 capsid (p24CA) antigen with high sensitivity, can pose important alternatives to screen for early infections. We evaluated the performance of the antibody and antigen components of the...

journal_title：Medical microbiology and immunology

authors： Wratil PR,Rabenau HF,Eberle J,Stern M,Münchhoff M,Friedrichs I,Stürmer M,Berger A,Kuttner-May S,Münstermann D,Lucht A,Meixenberger K,Bannert N,Keppler OT

更新日期：2020-04-01 00:00:00

abstract：:Lack of virus-specific cell-mediated immunity (CMI) is associated with worse viral infection outcome in hematopoietic stem cell transplantation (HSCT). We aimed to evaluate the role of immunological monitoring of Epstein-Barr virus (EBV) infection in addition to virological one in 33 adult and 18 pediatric allogeneic ...

journal_title：Medical microbiology and immunology

authors： Chiereghin A,Piccirilli G,Belotti T,Prete A,Bertuzzi C,Gibertoni D,Gabrielli L,Turello G,Borgatti EC,Barbato F,Sessa M,Arpinati M,Bonifazi F,Lazzarotto T

更新日期：2019-12-01 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that utilizes the quorum-sensing (QS) process to regulate the production of different virulence factors and biofilm. N-3-oxo-dodecanoyl-L-homoserine lactone (C12) is a key QS molecule of P. aeruginosa which interacts with the mammalian immune cells and modulates thei...

journal_title：Medical microbiology and immunology

authors： Singh PK,Yadav VK,Kalia M,Sharma D,Pandey D,Agarwal V

更新日期：2019-12-01 00:00:00

abstract：:Influenza remains an important threat for human health, despite the extensive study of influenza viruses and the production of effective vaccines. In contrast to virus genetics determinants, host genetic factors with clinical impact remained unexplored until recently. The association between three single nucleotide po...

journal_title：Medical microbiology and immunology

authors： Chatzopoulou F,Gioula G,Kioumis I,Chatzidimitriou D,Exindari M

更新日期：2019-10-01 00:00:00

abstract：:Both aging and treated human immunodeficiency virus (HIV) infection are characterized by low-level chronic inflammation and immune activation which contribute to the development of age-related diseases, frailty, and early mortality. Chronic cytomegalovirus (CMV) infection is highly prevalent in older adults and HIV-in...

journal_title：Medical microbiology and immunology

authors： Tavenier J,Margolick JB,Leng SX

更新日期：2019-08-01 00:00:00

abstract：:Roizman's definition of herpesviral latency, which applies also to cytomegaloviruses (CMVs), demands maintenance of reactivation-competent viral genomes after clearance of productive infection. It is more recent understanding that failure to complete the productive viral cycle for virus assembly and release does not i...

journal_title：Medical microbiology and immunology

authors： Renzaho A,Schmiedeke JK,Griessl M,Kühnapfel B,Seckert CK,Lemmermann NAW

更新日期：2019-08-01 00:00:00

abstract：:The new QuantiFERON-TB Gold Plus employs modified peptides optimized to elicit an IFNγ response from CD8+ cytotoxic T lymphocytes in addition to CD4+ T cells. With a view to improve the difficult identification of TB cases, we assessed the combination of two specific immunological markers comprising IFNγ secretion and...

journal_title：Medical microbiology and immunology

authors： Sauzullo I,Mengoni F,Mascia C,Pavone P,Savelloni G,Massetti AP,Lichtner M,Vullo V,Mastroianni CM

更新日期：2019-04-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infections affect 71 million people worldwide, often resulting in severe liver damage. Since 2014 highly efficient therapies based on directly acting antivirals (DAAs) are available, offering cure rates of almost 100%, if the infection is diagnosed in time. It took more than a decade to...

journal_title：Medical microbiology and immunology

authors： Lohmann V

更新日期：2019-02-01 00:00:00

abstract：:Phosphorylcholine (ChoP) is covalently incorporated into bacterial surface structures, contributing to host mimicry and promoting adhesion to surfaces. Our aims were to determine the frequency of ChoP display among Aggregatibacter actinomycetemcomitans strains, to clarify which surface structures bear ChoP, and whethe...

journal_title：Medical microbiology and immunology

authors： Ihalin R,Zhong D,Karched M,Chen C,Asikainen S

更新日期：2018-11-01 00:00:00

abstract：:Mastitis, which is generally described as an inflammation of breast tissue, is a common and debilitating disease which frequently results in the cessation of exclusive breastfeeding and affects up to 33% of lactating women. The condition is a primary cause of decreased milk production and results in organoleptic and n...

journal_title：Medical microbiology and immunology

authors： Angelopoulou A,Field D,Ryan CA,Stanton C,Hill C,Ross RP

更新日期：2018-04-01 00:00:00

abstract：:Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Previous studies have demonstrated that the difference among clinical forms of leprosy can be associated with the immune response of patients, mainly by T helper (Th) and regulatory T cells (Tregs). Then, aiming at clarifying the immune response, ...

journal_title：Medical microbiology and immunology

authors： Azevedo MCS,Marques H,Binelli LS,Malange MSV,Devides AC,Silva EA,Fachin LRV,Ghidella CC,Soares CT,Garlet GP,Rosa PS,Belone AFF,Trombone APF

更新日期：2017-12-01 00:00:00

abstract：:Killer cell immunoglobulin like receptors (KIRs) have a principal role in regulating the effector functions of NK cells, particularly in viral infections. The major ligands for KIRs are human leukocyte antigen (HLA) class I molecules. The aim of this study is to investigate the possible association of KIR genes, their...

journal_title：Medical microbiology and immunology

authors： Shah-Hosseini A,Jafari M,Mohammadi A,Sanaei R,Alavian SM,Doosti-Irani A,Nooradeh Keykavousi M,Tajik N

更新日期：2017-12-01 00:00:00

abstract：:Congenital cytomegalovirus (CMV) infection is the leading cause for sensorineural hearing loss and mental retardation in children without genetic diseases worldwide. There is little evidence guiding therapeutic strategies during pregnancy when intrauterine fetal CMV infection is confirmed. We provide a systematic revi...

journal_title：Medical microbiology and immunology

authors： Seidel V,Feiterna-Sperling C,Siedentopf JP,Hofmann J,Henrich W,Bührer C,Weizsäcker K

更新日期：2017-10-01 00:00:00

abstract：:Head and neck cancers constitute a multifactorial global disease burden and are associated with human papilloma virus (HPV) as a possible risk factor. The aim of the study is to understand the relationship between HPV and the development of head and neck lesions in Indian patients. To this end, frequency of HPV was as...

journal_title：Medical microbiology and immunology

authors： Sarkar S,Alam N,Chakraborty J,Biswas J,Mandal SS,Roychoudhury S,Panda CK

更新日期：2017-06-01 00:00:00

abstract：:IFN-γ release assays (IGRAs) often present false-negative or indeterminate results in children with tuberculosis. HIV co-infection may contribute to decreased sensitivity of IGRAs by impairing T-cell IFN-γ expression. Measurement of alternative cytokines in QuantiFERON® (QFT) supernatants can circumvent the IFN-γ-depe...

journal_title：Medical microbiology and immunology

authors： Lundtoft C,Awuah AA,Nausch N,Enimil A,Mayatepek E,Owusu-Dabo E,Jacobsen M

更新日期：2017-06-01 00:00:00

abstract：:The pathogenesis of Staphylococcus aureus from local infection to systemic dissemination involves a range of virulence factors including structural and secreted products. Among various control mechanisms, small noncoding RNAs are involved in the regulation of multiple pathogenicity factors in S. aureus. The sRNA SprX ...

journal_title：Medical microbiology and immunology

authors： Kathirvel M,Buchad H,Nair M

更新日期：2016-12-01 00:00:00

abstract：:IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab')2 domain of IgG, various effector functions become activated via the constant Fcγ part bridging IgG-opsonized targets to FcγR-express...

journal_title：Medical microbiology and immunology

authors： Corrales-Aguilar E,Trilling M,Reinhard H,Falcone V,Zimmermann A,Adams O,Santibanez S,Hengel H

更新日期：2016-10-01 00:00:00

abstract：:Burkholderia pseudomallei, a gram-negative intracellular bacterium, is a causative agent of melioidosis. The bacterium has been shown to induce the innate immune response, particularly pro-inflammatory cytokine production in several of both mouse and human cell types. In the present study, we investigate host immune r...

journal_title：Medical microbiology and immunology

authors： Kulsantiwong P,Pudla M,Boondit J,Wikraiphat C,Dunachie SJ,Chantratita N,Utaisincharoen P

更新日期：2016-06-01 00:00:00

abstract：:Proteus mirabilis (P. mirabilis), a gram-negative enteric bacterium, frequently causes urinary tract infections. Many virulence factors of uropathogenic P. mirabilis have been identified, including urease, flagella, hemolysin and fimbriae. However, the functions of polyphosphate kinase (PPK), which are related to the ...

journal_title：Medical microbiology and immunology

authors： Peng L,Jiang Q,Pan JY,Deng C,Yu JY,Wu XM,Huang SH,Deng XY

更新日期：2016-04-01 00:00:00

abstract：:The administration of drugs to inhibit metabolic pathways not only reduces the risk of obesity-induced diseases in humans but may also hamper the replication of different viral pathogens. In order to investigate the value of the US Food and Drug Administration-approved anti-obesity drug orlistat in view of its anti-vi...

journal_title：Medical microbiology and immunology

authors： Ammer E,Nietzsche S,Rien C,Kühnl A,Mader T,Heller R,Sauerbrei A,Henke A

更新日期：2015-12-01 00:00:00

abstract：:Mycobacterium avium subsp. paratuberculosis (MAP) has long been implicated as a triggering agent in Crohn's disease (CD). In this study, we investigated the growth/persistence of both M. avium subsp. hominissuis (MAH) and MAP, in macrophages from healthy controls (HC), CD and ulcerative colitis patients. For viability...

journal_title：Medical microbiology and immunology

authors： Nazareth N,Magro F,Appelberg R,Silva J,Gracio D,Coelho R,Cabral JM,Abreu C,Macedo G,Bull TJ,Sarmento A

更新日期：2015-12-01 00:00:00

abstract：:Porphyromonas gingivalis, a periodontal pathogen, is epidemiologically associated with oral squamous cell carcinoma (OSCC). Matrix metalloproteinase 9 (MMP9) which degrades the extracellular matrix and basement membrane components has been implicated in invasion and metastasis of tumor cells. We previously reported th...

journal_title：Medical microbiology and immunology

authors： Inaba H,Amano A,Lamont RJ,Murakami Y

更新日期：2015-10-01 00:00:00

abstract：:Turkey is seeing a steady rise in rates of HIV infection in the country. The number of individuals with HIV/AIDS was greater than 7000 in 2014 according to data released by the Ministry of Health, and heterosexual contacts were reported to be the main transmission routes. Istanbul has the highest number of reported ca...

journal_title：Medical microbiology and immunology

authors： Köksal MO,Beka H,Lübke N,Verheyen J,Eraksoy H,Cagatay A,Kaiser R,Akgül B,Agacfidan A

更新日期：2015-08-01 00:00:00

abstract：:Cytomegalovirus vaccine development started in the 1970s with attenuated strains. In the 1980s, one of the strains was shown to be safe and effective in renal transplant patients. Then, attention switched to glycoprotein gB, which was shown to give moderate but transient protection against acquisition of the virus by ...

journal_title：Medical microbiology and immunology

authors： Plotkin S

更新日期：2015-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection modulates the host cell cycle to create an environment that is optimal for viral gene expression, DNA replication, and production of infectious virus. The virus mostly infects quiescent cells and thus must push the cell into G1 phase of the cell cycle to co-opt the cellular mecha...

journal_title：Medical microbiology and immunology

authors： Spector DH

更新日期：2015-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is the most common virus infection in the developing fetus. A fraction of infants infected in utero develop significant life-threatening and organ-threatening disease with over 90% of infected infants exhibiting no clinical evidence of infection in the newborn period. However, about 10% of...

journal_title：Medical microbiology and immunology

authors： Britt W

更新日期：2015-06-01 00:00:00

abstract：:Homeostasis underpins at a systems level the regulatory control of immunity and metabolism. While physiologically these systems are often viewed as independent, there is increasing evidence showing a tight coupling between immune and metabolic functions. Critically upon infection, the homeostatic regulation for both i...

journal_title：Medical microbiology and immunology

authors： Kotzamanis K,Angulo A,Ghazal P

更新日期：2015-06-01 00:00:00

abstract：:Presence of point mutations within the drug resistance determining regions of Mycobacterium leprae (M. leprae) genome confers molecular basis of drug resistance to dapsone, rifampin and ofloxacin in leprosy. This study is focused on the identification of mutations within the rpoB gene region of M. leprae that are spec...

journal_title：Medical microbiology and immunology

authors： Vedithi SC,Lavania M,Kumar M,Kaur P,Turankar RP,Singh I,Nigam A,Sengupta U

更新日期：2015-04-01 00:00:00

abstract：:Streptococcus pyogenes is a human pathogen which causes a spectrum of diseases ranging from pharyngitis to rheumatic fever, necrotising fasciitis and toxic shock syndrome. Development of a vaccine for S. pyogenes has been confounded both by the diversity of the disease-causing serotypes and the spectre of inadvertentl...

journal_title：Medical microbiology and immunology

authors： Radcliff FJ,Fraser JD,Proft T

更新日期：2015-04-01 00:00:00

abstract：:Therapeutic vaccination for the treatment of chronic hepatitis B has thus far been unsatisfactory. In this review, we discuss potential new therapeutic vaccination strategies and other immunotherapeutic approaches that aim to achieve efficient restoration of HBV immunity in chronically infected patients. ...

journal_title：Medical microbiology and immunology

authors： Koh S,Bertoletti A

更新日期：2015-02-01 00:00:00

abstract：:Vaccination has proven to be one of the best weapons protecting the mankind against infectious diseases. Along with the huge progress in microbiology, numerous highly efficacious and safe vaccines have been produced by conventional technology (cultivation), by the use of molecular biology (genetic modification), or by...

journal_title：Medical microbiology and immunology

authors： Doerr HW,Berger A

更新日期：2014-12-01 00:00:00

abstract：:The rapid and correct identification of pathogens is of paramount importance for the treatment of patients with invasive infections. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) can speed up the identification of bacteria and fungi and has quickly been embraced by medical...

journal_title：Medical microbiology and immunology

authors： Hamprecht A,Christ S,Oestreicher T,Plum G,Kempf VA,Göttig S

更新日期：2014-04-01 00:00:00

abstract：:The fatal inhalation infection caused by Bacillus anthracis results from a complex pathogenic cycle involving release of toxins by bacteria that germinate from spores. Currently available vaccines against anthrax consist of protective antigen (PA), one of the anthrax toxin components. However, these PA-based vaccines ...

journal_title：Medical microbiology and immunology

authors： Sinha K,Bhatnagar R

更新日期：2013-04-01 00:00:00

abstract：:We evaluated the long-term effects of the single oral administration of a new CXCR4 antagonist, KRH-3955, on elevation of white blood cell (WBC), neutrophil and lymphocyte counts in normal cynomolgus monkeys. In the monkeys treated with 0, 2, 20, 200 mg/kg of the compound, WBC, neutrophil and lymphocyte counts increas...

journal_title：Medical microbiology and immunology

authors： Nakasone T,Kumakura S,Yamamoto M,Murakami T,Yamamoto N

更新日期：2013-04-01 00:00:00

abstract：:Cytomegaloviruses (CMVs) are large double-stranded DNA viruses that replicate slowly and cause life-long persisting infections in their hosts. To achieve this, the CMVs had to evolve numerous countermeasures against innate and adaptive immune responses. Induction of programmed cell death is one important host defense ...

journal_title：Medical microbiology and immunology

authors： Handke W,Krause E,Brune W

更新日期：2012-11-01 00:00:00

abstract：:Low public awareness of cytomegalovirus (CMV) results from the only mild and transient symptoms that it causes in the healthy immunocompetent host, so that primary infection usually goes unnoticed. The virus is not cleared, however, but stays for the lifetime of the host in a non-infectious, replicatively dormant stat...

journal_title：Medical microbiology and immunology

authors： Seckert CK,Griessl M,Büttner JK,Scheller S,Simon CO,Kropp KA,Renzaho A,Kühnapfel B,Grzimek NK,Reddehase MJ

更新日期：2012-11-01 00:00:00

abstract：:Pertussis Toxin (PTx) is one of the most important virulence factors of Bordetella pertussis, the cause of whooping cough. Therefore, the inactivated toxin is an obligatory constituent of acellular pertussis vaccines. It is described in the literature that both native PTx and recombinant Pertussis Toxin (PTg) activate...

journal_title：Medical microbiology and immunology

authors： Bache C,Spreitzer I,Becker B,Loeschner B,Rosskopf U,Hanschmann KM,Schwanig M,Schneider CK,Lieb B,Montag T

更新日期：2012-08-01 00:00:00