Interferon induces an antiviral state in ganglioside-deficient transformed mouse fibroblasts.

Abstract:

:The antiviral activity of mouse fibroblast interferon against vesicular stomatitis virus was investigated in L-929 mouse fibroblasts and the ganglioside-deficient L-929 mutant cells (ATCC clone NCTC 2071). Although it has been widely reported that gangliosides serve as primary receptors for interferon at the cellular membrane, only a small difference in interferon sensitivity was observed between the wild-type L-929 and the ganglioside-deficient NCTC 2071 cells. It was not possible, however, to overcome this difference by administration of exogenous gangliosides.

journal_name

Med Microbiol Immunol

authors

Schiffmann D,Koschel K

doi

10.1007/BF02125527

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

281-9

issue

4

eissn

0300-8584

issn

1432-1831

journal_volume

169

pub_type

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