Abstract:
:Cytomegalovirus vaccine development started in the 1970s with attenuated strains. In the 1980s, one of the strains was shown to be safe and effective in renal transplant patients. Then, attention switched to glycoprotein gB, which was shown to give moderate but transient protection against acquisition of the virus by women. The identification of the pp65 tegument protein as the principal target of cellular immune responses resulted in new approaches, particularly DNA, plasmids to protect hematogenous stem cell recipients. The subsequent discovery of the pentameric protein complex that generates most neutralizing antibodies led to efforts to incorporate that complex into vaccines. At this point, there are many candidate CMV vaccines, including live recombinants, replication-defective virus, DNA plasmids, soluble pentameric proteins, peptides, virus-like particles and vectored envelope proteins.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Plotkin Sdoi
10.1007/s00430-015-0388-zsubject
Has Abstractpub_date
2015-06-01 00:00:00pages
247-54issue
3eissn
0300-8584issn
1432-1831journal_volume
204pub_type
历史文章,杂志文章,评审abstract::The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B(2) (B(2)R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B(2)R (B(2)R(-/-) mice) were sh...
journal_title:Medical microbiology and immunology
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doi:10.1007/s00430-008-0103-4
更新日期:2009-02-01 00:00:00
abstract::We previously reported that Trypanosoma cruzi, the agent of Chagas disease, induces in congenitally infected fetuses a strong, adult-like parasite-specific CD8(+) T cell response producing IFN-γ (Hermann et al. in Blood 100:2153-2158, 2002). This suggests that the parasite is able to overcome the immaturity of neonata...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-011-0217-y
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abstract::Oral treatment of mice with a combination of non-absorbable broad spectrum antibiotics at a dose level high enough to sterilize the digestive tract within five days of treatment, has been found to have a significant negative effect on the relative weight of the thymus. From the age of 12 weeks onwards, the mean relati...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123870
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abstract::The effect of red blood cell age on the susceptibility towards NDV- induced hemolysis has been investigated. It was found that young sheep red blood cells (SRBC), although more resistant to hypotonic hemolysis, are more susceptible towards viral hemolysis than older cells. This may be because young red blood cells hav...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02122855
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-012-0238-1
更新日期:2012-08-01 00:00:00
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
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abstract::Congenital cytomegalovirus (CMV) infection is the leading cause for sensorineural hearing loss and mental retardation in children without genetic diseases worldwide. There is little evidence guiding therapeutic strategies during pregnancy when intrauterine fetal CMV infection is confirmed. We provide a systematic revi...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
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journal_title:Medical microbiology and immunology
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abstract::The improved Auxotab Enteric I System was re-evaluated and found to correlate 98% with conventional methods for the identification of Enterobacteriaceae. Possible Reasons for previous poor results with this system are discussed. ...
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-006-0032-z
更新日期:2007-06-01 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00196051
更新日期:1994-07-01 00:00:00
abstract::Various strains of Helicobacter pylori were able to lyse erythrocytes from sheep, horse, and human when grown on blood agar. The hemolysis did not depend on the production of the vacuolating cytotoxin VacA as demonstrated by the hemolytic behavior of an isogenic vacA-negative mutant strain. The hemolytic activity coul...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s004300050062
更新日期:1998-03-01 00:00:00
abstract::The present study analyses the susceptibility of human bladder-derived cells (HT-1376) to the infection by herpes simplex virus type 2 (HSV-2) and Chlamydia trachomatis, as well as to the adhesiveness of uropathogenic bacteria. HT-1376 cells were efficiently infected by HSV-2 strain 333, as demonstrated by immunofluor...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s004300100067
更新日期:2001-09-01 00:00:00
abstract::Lack of virus-specific cell-mediated immunity (CMI) is associated with worse viral infection outcome in hematopoietic stem cell transplantation (HSCT). We aimed to evaluate the role of immunological monitoring of Epstein-Barr virus (EBV) infection in addition to virological one in 33 adult and 18 pediatric allogeneic ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-019-00629-2
更新日期:2019-12-01 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02121133
更新日期:1978-11-17 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
abstract::TT virus (TTV) is a newly discovered virus from a patient with post-transfusion hepatitis. We investigated the frequency and pathogenesis of TTV infection in children. A semi-nested PCR assay was used to amplify TTV-DNA in serum samples from 254 ambulatory children without liver disease, 20 with hepatitis of unknown e...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s004300050109
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journal_title:Medical microbiology and immunology
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abstract::The aroB gene from Helicobacter pylori strain P1 was cloned and further characterized by sequence analysis and by functional complementation of the aroB mutation in Escherichia coli. The aroB gene encodes the enzyme 3-dehydroquinate synthase which catalyzes one of the early steps in the shikimate pathway. This pathway...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
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journal_title:Medical microbiology and immunology
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更新日期:2018-11-01 00:00:00
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journal_title:Medical microbiology and immunology
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abstract::We evaluated the long-term effects of the single oral administration of a new CXCR4 antagonist, KRH-3955, on elevation of white blood cell (WBC), neutrophil and lymphocyte counts in normal cynomolgus monkeys. In the monkeys treated with 0, 2, 20, 200 mg/kg of the compound, WBC, neutrophil and lymphocyte counts increas...
journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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journal_title:Medical microbiology and immunology
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abstract::A coupled luminescent method (CLM) based on glyceraldehyde-3-phosphate dehydrogenase released from injured target cells was used to evaluate the cytotoxicity of antigen-specific HLA class I-restricted CTLs. In contrast to established methods, CLM does not require the pretreatment of target cells with radioactive or to...
journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-007-0071-0
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