Circumventing failed antiviral immunity in chronic hepatitis B virus infection: triggering virus-specific or innate-like T cell response?

abstract：:Different culture conditions, devitalizing treatments, and preservation procedures were tested for the production of protein A-bearing cells of Staphylococcus aureus ATCC 12598. Native cells with the highest IgG-binding activity were obtained after cultivation at 37 degrees C for 24-48 h in enriched media. Devitalizat...

journal_title：Medical microbiology and immunology

authors： Ansorg RA,Zarifoglu FI

更新日期：1986-01-01 00:00:00

abstract：:IFN-γ release assays (IGRAs) often present false-negative or indeterminate results in children with tuberculosis. HIV co-infection may contribute to decreased sensitivity of IGRAs by impairing T-cell IFN-γ expression. Measurement of alternative cytokines in QuantiFERON® (QFT) supernatants can circumvent the IFN-γ-depe...

journal_title：Medical microbiology and immunology

authors： Lundtoft C,Awuah AA,Nausch N,Enimil A,Mayatepek E,Owusu-Dabo E,Jacobsen M

更新日期：2017-06-01 00:00:00

abstract：:In resource-limited or point-of-care settings, rapid diagnostic tests (RDTs), that aim to simultaneously detect HIV antibodies and p24 capsid (p24CA) antigen with high sensitivity, can pose important alternatives to screen for early infections. We evaluated the performance of the antibody and antigen components of the...

journal_title：Medical microbiology and immunology

authors： Wratil PR,Rabenau HF,Eberle J,Stern M,Münchhoff M,Friedrichs I,Stürmer M,Berger A,Kuttner-May S,Münstermann D,Lucht A,Meixenberger K,Bannert N,Keppler OT

更新日期：2020-04-01 00:00:00

abstract：:IgG subclass antibodies to Pseudomonas aeruginosa outer membrane proteins (OMP) were investigated in serum from cystic fibrosis (CF) patients by immunoblotting and enzyme-linked immunosorbent assay (ELISA). Fifteen patients (eight in good and seven in poor clinical condition) have been followed for an average of 13 ye...

journal_title：Medical microbiology and immunology

authors： Pressler T,Kronborg G,Shand GH,Mansa B,Høiby N

更新日期：1992-01-01 00:00:00

abstract：:Illness and death of mice infected by intracerebral inoculation with lymphocytic choriomeningitis virus are pathologic immune phenomena, and mice thus infected were protected when immunosuppressed with cyclosporin A (CSA), although the virus multiplied extensively in all major organs. Concentrations remained high as l...

journal_title：Medical microbiology and immunology

authors： Löliger C,Lehmann-Grube F

更新日期：1985-01-01 00:00:00

abstract：:As enteroviruses are mainly transmitted by the fecal-oral route, this study was initiated to investigate the nature of the binding of enteroviruses to human skin. Using poliovirus 1, Mahoney, we investigated the overall effectiveness of soap and water hand-washing of 1 and 5 min duration. The virus-skin interaction wa...

journal_title：Medical microbiology and immunology

authors： Schürmann W,Eggers HJ

更新日期：1985-01-01 00:00:00

abstract：:Virus adsorption and uptake of human rhinovirus 14 (HRV14) were studied with HeLa cells and baby hamster kidney (BHK) cells which were transfected with the HRV14 receptor intercellular adhesion molecule-1 (ICAM-1). Transmission electron microscopy of HeLa cells revealed that HRV14 was internalized via clathrin-coated ...

journal_title：Medical microbiology and immunology

authors： Grunert HP,Wolf KU,Langner KD,Sawitzky D,Habermehl KO,Zeichhardt H

更新日期：1997-06-01 00:00:00

abstract：:Monoclonal antibody (MAb) 2c, specific for glycoprotein B of herpes simplex virus (HSV), had been shown to mediate clearance of infection from the mucous membranes of mice, thereby completely inhibiting mucocutaneous inflammation and lethality, even in mice depleted of both CD4(+) and CD8(+) cells. Additionally, gangl...

journal_title：Medical microbiology and immunology

authors： Däumer MP,Schneider B,Giesen DM,Aziz S,Kaiser R,Kupfer B,Schneweis KE,Schneider-Mergener J,Reineke U,Matz B,Eis-Hübinger AM

更新日期：2011-05-01 00:00:00

abstract：:Head and neck cancers constitute a multifactorial global disease burden and are associated with human papilloma virus (HPV) as a possible risk factor. The aim of the study is to understand the relationship between HPV and the development of head and neck lesions in Indian patients. To this end, frequency of HPV was as...

journal_title：Medical microbiology and immunology

authors： Sarkar S,Alam N,Chakraborty J,Biswas J,Mandal SS,Roychoudhury S,Panda CK

更新日期：2017-06-01 00:00:00

abstract：:The presence of Borna disease virus (BDV)-specific RNA was traced by the reverse transcriptase-polymerase chain reaction in conjunctival fluid, nasal secretions and saliva of horses which were seropositive but did not have any history of clinical Borna disease. Positive reactions encompassed sequences encoding the p24...

journal_title：Medical microbiology and immunology

authors： Richt JA,Herzog S,Haberzettl K,Rott R

更新日期：1993-12-01 00:00:00

abstract：:The structural relation of YOP-1 of "european" and "american" Yersinia enterocolitica serotypes O:3, O:9, O:5,27, and O:8 and O:20, respectively, and Y. pseudotuberculosis serotypes I, II, and III was compared by sodium dodecyl sulfate polyacrylamide gel electrophoresis and peptide mapping using Staphylococcus aureus ...

journal_title：Medical microbiology and immunology

authors： Mack D,Pulz M,Heesemann J

更新日期：1991-01-01 00:00:00

abstract：:The production of thermolabile (LT) enterotoxin was compared in a defined medium reported by Staples et al. (SAG medium) for the production of thermostable (ST) enterotoxin and the Casamino acids-Yeast extract (CAYE) medium. Aliquots were drawn frum cultures of an enterotoxigenic (LT+, ST+) E. coli in both media at di...

journal_title：Medical microbiology and immunology

authors： Fontes CF,Ricci LC,Oliveira MS,Gatti MS,Pestana de Castro AF

更新日期：1982-01-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET format...

journal_title：Medical microbiology and immunology

authors： Lögters T,Margraf S,Altrichter J,Cinatl J,Mitzner S,Windolf J,Scholz M

更新日期：2009-11-01 00:00:00

abstract：:The effects of sheep anti-murine recombinant tumor necrosis factor-alpha (TNF-alpha) on resistance to Listeria monocytogenes infection were studied in T cell-deficient nu/nu mice. The sheep anti-TNF-alpha antibody preparation was specific for TNF since it neutralized 300 U of recombinant murine TNF-alpha in vitro at a...

journal_title：Medical microbiology and immunology

authors： Hauser T,Frei K,Zinkernagel RM,Leist TP

更新日期：1990-01-01 00:00:00

abstract：:We evaluated the long-term effects of the single oral administration of a new CXCR4 antagonist, KRH-3955, on elevation of white blood cell (WBC), neutrophil and lymphocyte counts in normal cynomolgus monkeys. In the monkeys treated with 0, 2, 20, 200 mg/kg of the compound, WBC, neutrophil and lymphocyte counts increas...

journal_title：Medical microbiology and immunology

authors： Nakasone T,Kumakura S,Yamamoto M,Murakami T,Yamamoto N

更新日期：2013-04-01 00:00:00

abstract：:The present study analyses the susceptibility of human bladder-derived cells (HT-1376) to the infection by herpes simplex virus type 2 (HSV-2) and Chlamydia trachomatis, as well as to the adhesiveness of uropathogenic bacteria. HT-1376 cells were efficiently infected by HSV-2 strain 333, as demonstrated by immunofluor...

journal_title：Medical microbiology and immunology

authors： Superti F,Longhi C,Di Biase AM,Tinari A,Marchetti M,Pisani S,Gallinelli C,Chiarini F,Seganti L

更新日期：2001-09-01 00:00:00

abstract：:The development in rabbits of antibodies against common thermolabile Escherichia coli surface antigens - and against O and K antigens - was investigated. Three strains, E3b (O75:K95:H5), E56b (O8:K27:H-), and H61 (O45:K1:H10), and five rabbits per strain were used. Immunization was carried out by routine procedures us...

journal_title：Medical microbiology and immunology

authors： Orskov F,Larsen JC,Orskov I

更新日期：1981-01-01 00:00:00

abstract：:Virus-induced antigens were isolated from MDV and HVT-infected cells by salt extraction with 3M KCl and purified by Con.A chromatography and isoelectric focusing. Electrophoretic analysis of 35S-methionine, 3H-fucose and 32P-orthophosphate labeled antigens revealed 7 different polypeptides, two of them containing labe...

journal_title：Medical microbiology and immunology

authors： Kaaden OR

更新日期：1977-10-07 00:00:00

abstract：:TT virus (TTV) is a newly discovered virus from a patient with post-transfusion hepatitis. We investigated the frequency and pathogenesis of TTV infection in children. A semi-nested PCR assay was used to amplify TTV-DNA in serum samples from 254 ambulatory children without liver disease, 20 with hepatitis of unknown e...

journal_title：Medical microbiology and immunology

authors： Iriyama M,Kimura H,Nishikawa K,Yoshioka K,Wakita T,Nishimura N,Shibata M,Ozaki T,Morishima T

更新日期：1999-11-01 00:00:00

abstract：:Quorum sensing system is a cell-to-cell communication system that plays a pivotal role in virulence expression in bacteria. Recent advances have demonstrated that the Pseudomonas aeruginosa quorum sensing molecule, N-3-oxododecanoyl homoserine lactone (3OC(12)-HSL), exerts effects on mammalian cells and modulates host...

journal_title：Medical microbiology and immunology

authors： Li H,Wang L,Ye L,Mao Y,Xie X,Xia C,Chen J,Lu Z,Song J

更新日期：2009-05-01 00:00:00

abstract：:Antibodies against the human coronavirus OC43 in human sera were measured by haemagglutination inhibition (HI), complement fixation (CF), and radial diffusion-haemolysis in gel (HIG) techniques. The apparent HI titres in a fraction of sera with no antibodies detectable by the two other methods were found to be reduced...

journal_title：Medical microbiology and immunology

authors： Hovi T

更新日期：1978-11-17 00:00:00

abstract：:Lactoferrin (Lf) is an iron-binding protein which plays an important role in the host defense systems of different mucosal surfaces including the intestinal mucosa. In the present research the role of apo-Lf and iron-saturated Lf in the invasion process of enteroinvasive bacteria, grown in iron stress or excess, was i...

journal_title：Medical microbiology and immunology

authors： Longhi C,Conte MP,Seganti L,Polidoro M,Alfsen A,Valenti P

更新日期：1993-03-01 00:00:00

abstract：:The aroB gene from Helicobacter pylori strain P1 was cloned and further characterized by sequence analysis and by functional complementation of the aroB mutation in Escherichia coli. The aroB gene encodes the enzyme 3-dehydroquinate synthase which catalyzes one of the early steps in the shikimate pathway. This pathway...

journal_title：Medical microbiology and immunology

authors： Bereswill S,Fassbinder F,Völzing C,Haas R,Reuter K,Ficner R,Kist M

更新日期：1997-10-01 00:00:00

abstract：:A microcytoxicity assay with 3H-proline prelabeled target cells was used for the detection of sensitized lymphoid spleen cells from STU inbred mice inoculated with Moloney sarcoma virus (MSV-M) or ascitic MSV-M tumor cells. The target cell line was derived from ascitic MSV-M tumor cells. With regard to the specificity...

journal_title：Medical microbiology and immunology

authors： Weiland E,Mussgay M

更新日期：1976-06-01 00:00:00

abstract：:Adaptation of Borrelia burgdorferi in the vector and vertebrate host is mediated by mechanisms that regulate differential expression of outer surface lipoproteins (Osps). In this study, real time PCR was applied to quantify tissue-specific expression of four linear plasmid (lp54)-encoded (ospA, zs7.a36, zs7.a66 zs7.a6...

journal_title：Medical microbiology and immunology

authors： Lederer S,Brenner C,Stehle T,Gern L,Wallich R,Simon MM

更新日期：2005-01-01 00:00:00

abstract：:Various strains of Helicobacter pylori were able to lyse erythrocytes from sheep, horse, and human when grown on blood agar. The hemolysis did not depend on the production of the vacuolating cytotoxin VacA as demonstrated by the hemolytic behavior of an isogenic vacA-negative mutant strain. The hemolytic activity coul...

journal_title：Medical microbiology and immunology

authors： Bereswill S,Fassbinder F,Völzing C,Covacci A,Haas R,Kist M

更新日期：1998-03-01 00:00:00

abstract：:Almost 4000 sera from seven African states were examined for antibodies to ATLV/HTLV-1. Between 1% and 8% of healthy people from sub-Saharan Africa have such antibodies. The highest frequency was observed in Gabon. There were considerable variations between villages. The percentage of seropositives and the mean titre ...

journal_title：Medical microbiology and immunology

authors： Hunsmann G,Bayer H,Schneider J,Schmitz H,Kern P,Dietrich M,Büttner DW,Goudeau AM,Kulkarni G,Fleming AF

更新日期：1984-01-01 00:00:00

abstract：:Surface proteins of nine Campylobacter jejuni strains belonging to three different serovia were extracted with lysozyme/ethylenediamine-tetraacetic acid. The preparations bound to isolated murine small intestinal cells and to a membrane fraction (MF) of isolated brush borders obtained by detergent treatment with Trito...

journal_title：Medical microbiology and immunology

authors： Moser I,Hellmann E

更新日期：1989-01-01 00:00:00

abstract：:Pertussis Toxin (PTx) is one of the most important virulence factors of Bordetella pertussis, the cause of whooping cough. Therefore, the inactivated toxin is an obligatory constituent of acellular pertussis vaccines. It is described in the literature that both native PTx and recombinant Pertussis Toxin (PTg) activate...

journal_title：Medical microbiology and immunology

authors： Bache C,Spreitzer I,Becker B,Loeschner B,Rosskopf U,Hanschmann KM,Schwanig M,Schneider CK,Lieb B,Montag T

更新日期：2012-08-01 00:00:00

abstract：:Roizman's definition of herpesviral latency, which applies also to cytomegaloviruses (CMVs), demands maintenance of reactivation-competent viral genomes after clearance of productive infection. It is more recent understanding that failure to complete the productive viral cycle for virus assembly and release does not i...

journal_title：Medical microbiology and immunology

authors： Renzaho A,Schmiedeke JK,Griessl M,Kühnapfel B,Seckert CK,Lemmermann NAW

更新日期：2019-08-01 00:00:00