The bradykinin B2 receptor in the early immune response against Listeria infection.

Abstract:

:The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B(2) (B(2)R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B(2)R (B(2)R(-/-) mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with Listeria monocytogenes. Levels of cytokines known to play a pivotal role in the early phase immune response against L. monocytogenes, IL-12p70 and IFN-gamma, were reduced in B(2)R(-/-) mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells. Thus, we show that bradykinin and the B(2)R play a role in early innate immune functions during bacterial infection.

journal_name

Med Microbiol Immunol

authors

Kaman WE,Wolterink AF,Bader M,Boele LC,van der Kleij D

doi

10.1007/s00430-008-0103-4

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

39-46

issue

1

eissn

0300-8584

issn

1432-1831

journal_volume

198

pub_type

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