Abstract:
:The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B(2) (B(2)R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B(2)R (B(2)R(-/-) mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with Listeria monocytogenes. Levels of cytokines known to play a pivotal role in the early phase immune response against L. monocytogenes, IL-12p70 and IFN-gamma, were reduced in B(2)R(-/-) mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells. Thus, we show that bradykinin and the B(2)R play a role in early innate immune functions during bacterial infection.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Kaman WE,Wolterink AF,Bader M,Boele LC,van der Kleij Ddoi
10.1007/s00430-008-0103-4subject
Has Abstractpub_date
2009-02-01 00:00:00pages
39-46issue
1eissn
0300-8584issn
1432-1831journal_volume
198pub_type
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