Abstract:
:Influenza remains an important threat for human health, despite the extensive study of influenza viruses and the production of effective vaccines. In contrast to virus genetics determinants, host genetic factors with clinical impact remained unexplored until recently. The association between three single nucleotide polymorphisms (SNPs) and influenza outcome in a European population was investigated in the present study. All samples were collected during the influenza A(H1N1)pdm09 post-pandemic period 2010-11 and a sufficient number of severe and fatal cases was included. Host genomic DNA was isolated from pharyngeal samples of 110 patients from northern Greece with severe (n = 59) or mild (n = 51) influenza A(H1N1)pdm09 disease, at baseline, and the genotype of CD55 rs2564978, C1QBP rs3786054 and FCGR2A rs1801274 SNPs was investigated. Our findings suggest a relationship between the two complement-related SNPs, namely, the rare TT genotype of CD55 and the rare AA genotype of C1QBP with increased death risk. No significant differences were observed for FCGR2A genotypes neither with fatality nor disease severity. Additional large-scale genetic association studies are necessary for the identification of reliable host genetic risk factors associated with influenza A(H1N1)pdm09 outcome. Prophylactic intervention of additional high-risk populations, according to their genetic profile, will be a key achievement for the fight against influenza viruses.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Chatzopoulou F,Gioula G,Kioumis I,Chatzidimitriou D,Exindari Mdoi
10.1007/s00430-018-0567-9subject
Has Abstractpub_date
2019-10-01 00:00:00pages
631-640issue
5eissn
0300-8584issn
1432-1831pii
10.1007/s00430-018-0567-9journal_volume
208pub_type
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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journal_title:Medical microbiology and immunology
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pub_type: 杂志文章
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