Abstract:
:The effects of sheep anti-murine recombinant tumor necrosis factor-alpha (TNF-alpha) on resistance to Listeria monocytogenes infection were studied in T cell-deficient nu/nu mice. The sheep anti-TNF-alpha antibody preparation was specific for TNF since it neutralized 300 U of recombinant murine TNF-alpha in vitro at a dilution of up to 1/1,000 but did not neutralize 32 U of interferon (IFN)-alpha, -beta or 32 U of IFN-gamma in vitro at a 1/20 dilution. When tested in vivo in sublethally Listeria-infected nu/nu or T cell-competent C57BL/6 or ICR mice, a single treatment of 0.2 ml anti-TNF-alpha given intraperitoneally on either day -1,0 or +1 resulted in the death of mice by day 5-7 due to the uncontrolled growth of Listeria; bacterial counts in spleen and liver were increased on days 3-5 by a factor of 10-1,000 in these organs. When examined histologically, organs from mice with the anti-TNF-alpha treatment contained more, and considerably bigger, lesions that exhibited central necrosis. The enhancing effect of anti-TNF-alpha on Listeria infection seemed greater early during Listeria infection on days 1-6 when compared to later phases of the infection around days 6-10. From the data presented we conclude that in addition to other lymphokines, such as IFN-gamma, TNF-alpha is of importance during the entire course of a Listeria infection in nu/nu mice.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Hauser T,Frei K,Zinkernagel RM,Leist TPdoi
10.1007/BF00198530subject
Has Abstractpub_date
1990-01-01 00:00:00pages
95-104issue
2eissn
0300-8584issn
1432-1831journal_volume
179pub_type
杂志文章abstract::The generation of rodent Plasmodium strains expressing fluorescent proteins in all life cycle stages has had a big impact on malaria research. With this tool in hand, for the first time it was possible to follow in real time by in vivo microscopy the infection route of Plasmodium sporozoites transmitted to the mammali...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-007-0044-3
更新日期:2007-09-01 00:00:00
abstract::Since the dynamics of transmission of human cytomegalovirus (HCMV) have not been clarified yet, we assessed a possible change in HCMV seroprevalence in Frankfurt am Main, Germany during the past twenty years and tried to detect variables with an impact on epidemiology. Between 1/1/1988 and 10/15/2008, a total of 54443...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-009-0136-3
更新日期:2010-02-01 00:00:00
abstract::The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B(2) (B(2)R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B(2)R (B(2)R(-/-) mice) were sh...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-008-0103-4
更新日期:2009-02-01 00:00:00
abstract::A total of 114 Clostridium difficile strains were analysed for a possible correlation between serological susceptibility to chloramphenicol, tetracycline and clindamycin, and serogrouping. All 17 chloramphenicol-resistant strains belonged to serovar I, while none of 32 tetracycline-resistant strains belonged to serova...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00200678
更新日期:1987-01-01 00:00:00
abstract::The effect of red blood cell age on the susceptibility towards NDV- induced hemolysis has been investigated. It was found that young sheep red blood cells (SRBC), although more resistant to hypotonic hemolysis, are more susceptible towards viral hemolysis than older cells. This may be because young red blood cells hav...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02122855
更新日期:1980-01-01 00:00:00
abstract::Both aging and treated human immunodeficiency virus (HIV) infection are characterized by low-level chronic inflammation and immune activation which contribute to the development of age-related diseases, frailty, and early mortality. Chronic cytomegalovirus (CMV) infection is highly prevalent in older adults and HIV-in...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-019-00591-z
更新日期:2019-08-01 00:00:00
abstract::Homeostasis underpins at a systems level the regulatory control of immunity and metabolism. While physiologically these systems are often viewed as independent, there is increasing evidence showing a tight coupling between immune and metabolic functions. Critically upon infection, the homeostatic regulation for both i...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-015-0402-5
更新日期:2015-06-01 00:00:00
abstract::Enterocytozoon bieneusi is emerging as an important cause of chronic diarrhoea in AIDS patients. Its reservoirs and transmission patterns are unknown. In this study, we have examined E. bieneusi sequences from four Rhesus macaques of different origin, which were kept at one animal facility. The sequences were identica...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-005-0240-y
更新日期:2005-08-01 00:00:00
abstract::IFN-γ release assays (IGRAs) often present false-negative or indeterminate results in children with tuberculosis. HIV co-infection may contribute to decreased sensitivity of IGRAs by impairing T-cell IFN-γ expression. Measurement of alternative cytokines in QuantiFERON® (QFT) supernatants can circumvent the IFN-γ-depe...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-017-0501-6
更新日期:2017-06-01 00:00:00
abstract::Vaccination has proven to be one of the best weapons protecting the mankind against infectious diseases. Along with the huge progress in microbiology, numerous highly efficacious and safe vaccines have been produced by conventional technology (cultivation), by the use of molecular biology (genetic modification), or by...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-014-0346-1
更新日期:2014-12-01 00:00:00
abstract::Tests were made on 169 sera from children up to 10 years of age for rotavirus antibodies by indirect immunofluorescence and complement fixation tests. The simian strain SA 11 served as a substitute antigen for the human rotavirus. Furthermore, the SA 11 complement-fixing antigen was compared with a commercial antigen ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123296
更新日期:1979-03-13 00:00:00
abstract::While the antigen structure of yeast cell walls is well known, the immunological cross reactivity of these is often difficult to interpret. The cross reactions of eight yeasts were tested in rabbit hyperimmune sera by the indirect immunofluorescence test. Among the eight species examined were the medically important y...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02120806
更新日期:1979-01-01 00:00:00
abstract::Epidemiological studies in Mecklenburg-Vorpommern have shown a high prevalence of Borrelia burgdorferi-infected ticks. A total of 17 B. burgdorferi sensu lato strains were isolated from ticks and investigated by Western blots (immunoblot) with eight monoclonal anti-bodies against different epitopes of the outer surfac...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract::Phosphorylcholine (ChoP) is covalently incorporated into bacterial surface structures, contributing to host mimicry and promoting adhesion to surfaces. Our aims were to determine the frequency of ChoP display among Aggregatibacter actinomycetemcomitans strains, to clarify which surface structures bear ChoP, and whethe...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-018-0554-1
更新日期:2018-11-01 00:00:00
abstract::In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4-6 weeks, followed by ivermectin (IVM) after 6 months. After 6-27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxycycline resulted in ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00430-007-0062-1
更新日期:2008-09-01 00:00:00
abstract::Presence of point mutations within the drug resistance determining regions of Mycobacterium leprae (M. leprae) genome confers molecular basis of drug resistance to dapsone, rifampin and ofloxacin in leprosy. This study is focused on the identification of mutations within the rpoB gene region of M. leprae that are spec...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-014-0354-1
更新日期:2015-04-01 00:00:00
abstract::Lactoferrin (Lf) is an iron-binding protein which plays an important role in the host defense systems of different mucosal surfaces including the intestinal mucosa. In the present research the role of apo-Lf and iron-saturated Lf in the invasion process of enteroinvasive bacteria, grown in iron stress or excess, was i...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00195948
更新日期:1993-03-01 00:00:00
abstract::The DNAs of two kinds of microorganisms from human leprosy lesion, Mycobacterium leprae and Corynebacterium tuberculostearicum (also known as "leprosy-derived corynebacterium" or LDC), have been analysed and compared with the genomes of reference bacteria of the CMN group (genera Corynebacterium, Mycobacterium and Noc...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00190309
更新日期:1988-01-01 00:00:00
abstract::Turkey is seeing a steady rise in rates of HIV infection in the country. The number of individuals with HIV/AIDS was greater than 7000 in 2014 according to data released by the Ministry of Health, and heterosexual contacts were reported to be the main transmission routes. Istanbul has the highest number of reported ca...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-015-0419-9
更新日期:2015-08-01 00:00:00
abstract::Interactions of virulent Leptospira interrogans with murine monocyte-macrophage-like J774A.1 cells and Vero (African green monkey kidney fibroblasts) cells from attachment to internalization were investigated by a series of morphological analysis. Fontana silver staining revealed that only the pathogenic leptospires w...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-007-0047-0
更新日期:2007-12-01 00:00:00
abstract::Various strains of Helicobacter pylori were able to lyse erythrocytes from sheep, horse, and human when grown on blood agar. The hemolysis did not depend on the production of the vacuolating cytotoxin VacA as demonstrated by the hemolytic behavior of an isogenic vacA-negative mutant strain. The hemolytic activity coul...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s004300050062
更新日期:1998-03-01 00:00:00
abstract::Several lines of evidence suggest a viral infection as the initiating event for the development of myocarditis (MC). Especially enteroviruses like coxsackie B3 virus have been shown to induce MC in humans and strains of MC-prone mice after an infection. The further course of the disease is, however, determined not onl...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-003-0217-7
更新日期:2004-05-01 00:00:00
abstract::We have studied the incidence of enterotoxigenic and enteropathogenic Escherichia coli strains associated with infant diarrhoeal disease in Galicia (North-west Spain). During a period of 9 months we isolated heat-labile enterotoxin-positive strains in 2.1% of children with diarrhoea examined, whereas the production of...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123802
更新日期:1983-01-01 00:00:00
abstract::The efficiency was examined of immunization with feline leukemia virus glycoprotein complexes (gp85 rosettes) to protect cats against tumors induced by feline sarcoma virus (FeSV). The glycoprotein was isolated from feline leukemia virus (FeLV). Young cats were vaccinated with the purified viral glycoprotein and chall...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123497
更新日期:1983-01-01 00:00:00
abstract::The prevalence of enterotoxigenic E coli (ETEC) as a pathogenic agent of diarrhoea in the Tel-Aviv (Israel) area was determined, and the isolated E. coli strains characterized. During three periods (summer 1977, summer 1978, and summer 1979), a total of 335 specimens were tested for the presence of E. coli producing L...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123712
更新日期:1980-01-01 00:00:00
abstract::The effect of immune bovine lactoserum (BLS) antipolyvalent enteropathogenic Escherichia coli on bacterial growth, viability and bacteria-induced fluid accumulation was examined in rabbit ileal loops. Human enteropathogenic E. coli strains 0125:K70 (B15), 0111:K58 (B4) and 055:K59 (B5) (1-3 X 10(9) per inoculum) induc...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123571
更新日期:1975-12-30 00:00:00
abstract::Outer membrane fractions (OMs) of nine Campylobacter (C.) jejuni and two C. coli strains belonging to different serovars, from human and various animal origins, were extracted by treatment with sodium N-lauryl sarcosinate. Using n-octyl-beta-D-glucopyranoside a 42-kDa protein and a flagella-enriched fraction were obta...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00191550
更新日期:1992-01-01 00:00:00
abstract::This is a summary of the recent work on some glycosidases of sand flies and their Leishmania parasites. Glycosidases catalyze the hydrolysis of complex sugar subunits of polysaccharides into simple sugars. Leishmania major parasites secrete chitinase and N-acetylglucosaminase, which enables them to survive in the gut ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s004300100079
更新日期:2001-11-01 00:00:00
abstract::The fatal inhalation infection caused by Bacillus anthracis results from a complex pathogenic cycle involving release of toxins by bacteria that germinate from spores. Currently available vaccines against anthrax consist of protective antigen (PA), one of the anthrax toxin components. However, these PA-based vaccines ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-012-0280-z
更新日期:2013-04-01 00:00:00
abstract::As enteroviruses are mainly transmitted by the fecal-oral route, this study was initiated to investigate the nature of the binding of enteroviruses to human skin. Using poliovirus 1, Mahoney, we investigated the overall effectiveness of soap and water hand-washing of 1 and 5 min duration. The virus-skin interaction wa...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02124807
更新日期:1985-01-01 00:00:00