当前位置： SCI文献检索 > MEDICAL MICROBIOLOGY AND IMMUNOLOGY期刊下所有文献 > T-cell immunity against cytomegalovirus in HIV infection and aging: relationships with inflammation, immune activation, and frailty.

T-cell immunity against cytomegalovirus in HIV infection and aging: relationships with inflammation, immune activation, and frailty.

Abstract：

:Both aging and treated human immunodeficiency virus (HIV) infection are characterized by low-level chronic inflammation and immune activation which contribute to the development of age-related diseases, frailty, and early mortality. Chronic cytomegalovirus (CMV) infection is highly prevalent in older adults and HIV-infected populations. A number of studies have shown that CMV induces broad and strong T-cell responses in CMV-seropositive older adults and HIV-infected individuals. CMV infection rarely develops into clinical disease in immunocompetent individuals. However, a large body of literature has shown adverse effects of chronic CMV infection on the health and longevity of these populations. It has been hypothesized that chronic CMV infection may be a driver of chronic inflammation and immune activation, and may further contribute to the development of frailty. Thus, there is a need to better understand the extent of the impact of chronic CMV infection on T-cell immunity and health in aging and HIV infection. In this review, we will address important considerations and challenges in the assessment of chronic CMV infection and CMV-specific T-cell responses. We will then review recent data on relationships between T-cell responses to CMV and levels of inflammatory markers and immune activation, as well as the onset of frailty.

journal_name

Med Microbiol Immunol

journal_title

Medical microbiology and immunology

authors

Tavenier J,Margolick JB,Leng SX

doi

10.1007/s00430-019-00591-z

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

289-294

issue

3-4

eissn

0300-8584

issn

1432-1831

pii

10.1007/s00430-019-00591-z

journal_volume

208

pub_type

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