Abstract：
:Head and neck cancers constitute a multifactorial global disease burden and are associated with human papilloma virus (HPV) as a possible risk factor. The aim of the study is to understand the relationship between HPV and the development of head and neck lesions in Indian patients. To this end, frequency of HPV was assessed in relation to different demographic and etiological features and correlated with patient survival. The prevalence of HPV significantly increased from mild dysplastic lesions (43.6%) to head and neck squamous cell carcinoma (HNSCC) stage IV (68.5%) with HPV 16 being pre-dominant in both dysplasia (43.8%) and HNSCC (61.5%). Similar trend was observed in increasing grades of the tumour. In invasive lesions, patients aged below the median age of onset showed significantly higher occurrence of HPV than those above it. Patients harbouring HPV showed a significantly better survival irrespective of age of onset. Likewise, better survival was observed in tobacco habit negative/HPV-positive patients, and as reflected in both univariate and multivariate analysis. Majority of the HPV 16-positive samples showed moderate/high nuclear expression of HPV E6 and E7 proteins in tumours and respective basal layer of adjacent normal tissues. Thus, our data indicate that frequent HPV infection, along with tobacco habit, is a pre-requisite factor for the development of HNSCC of Indian patients but offers a better survival even during tobacco usage, implicating its diagnostic and prognostic importance.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Sarkar S,Alam N,Chakraborty J,Biswas J,Mandal SS,Roychoudhury S,Panda CKdoi
10.1007/s00430-017-0502-5subject
Has Abstractpub_date
2017-06-01 00:00:00pages
267-276issue
3eissn
0300-8584issn
1432-1831pii
10.1007/s00430-017-0502-5journal_volume
206pub_type
杂志文章abstract：:A microcytoxicity assay with 3H-proline prelabeled target cells was used for the detection of sensitized lymphoid spleen cells from STU inbred mice inoculated with Moloney sarcoma virus (MSV-M) or ascitic MSV-M tumor cells. The target cell line was derived from ascitic MSV-M tumor cells. With regard to the specificity...
journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF02121319
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF00189427
更新日期：1992-01-01 00:00:00
abstract：:It is known that tetraspanin proteins are involved in many physiological somatic cell mechanisms. Additionally, research has indicated they also have a role in various infectious diseases and cancers. This review focuses on the molecular interactions underlying the tetraspanin web formation in gametes. Primarily, tetr...
journal_title：Medical microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/s00430-015-0399-9
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/s00430-007-0047-0
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF00190308
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF02125494
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF00192465
更新日期：1990-01-01 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF02123765
更新日期：1984-01-01 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/s00430-006-0032-z
更新日期：2007-06-01 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/s004300050101
更新日期：1999-08-01 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/s00430-006-0028-8
更新日期：2007-06-01 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF00193850
更新日期：1991-01-01 00:00:00
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journal_title：Medical microbiology and immunology
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doi：10.1007/s00430-014-0354-1
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journal_title：Medical microbiology and immunology
pub_type： 临床试验,杂志文章
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更新日期：1977-05-18 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/s00430-015-0419-9
更新日期：2015-08-01 00:00:00
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journal_title：Medical microbiology and immunology
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF00191061
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journal_title：Medical microbiology and immunology
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doi：10.1007/s00430-005-0240-y
更新日期：2005-08-01 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
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journal_title：Medical microbiology and immunology
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF02121133
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF00196051
更新日期：1994-07-01 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2020-08-01 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/s00430-014-0353-2
更新日期：2015-04-01 00:00:00
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journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF02123683
更新日期：1986-01-01 00:00:00
abstract：:The avirulent Salmonella typhimurium galE strain G30, following oral feeding to mice, developed a state of immunity to a secondary oral challenge with virulent Salmonella typhimurium. This immunity was concommitant with the development of intestinal and serum antibodies and delayed-type hyepersensitivity (DTH) to Salm...
journal_title：Medical microbiology and immunology
pub_type： 杂志文章
doi：10.1007/BF02121760
更新日期：1980-01-01 00:00:00
