Salmonellosis in mice: studies on oral immunization with live avirulent vaccines.

Abstract:

:The avirulent Salmonella typhimurium galE strain G30, following oral feeding to mice, developed a state of immunity to a secondary oral challenge with virulent Salmonella typhimurium. This immunity was concommitant with the development of intestinal and serum antibodies and delayed-type hyepersensitivity (DTH) to Salmonella antigens. In contrast, repeated oral doses of a hybrid E. coli vaccine, which expresses the O antigens of Salmonella typhimurium, provided a lesser degree of immunity and, although able to stimulate the formation of serum antibodies, it elicited only a low level of intestinal antibodies and no measurable DTH.

journal_name

Med Microbiol Immunol

authors

Moser I,Hohmann A,Schmidt G,Rowley D

doi

10.1007/BF02121760

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

119-28

issue

2

eissn

0300-8584

issn

1432-1831

journal_volume

168

pub_type

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