Abstract:
:Spleen T lymphocytes from mice undergoing acute infection with lymphocytic choriomeningitis virus (LCM virus) were negatively selected by treatment with anti-Lyt or anti-L3T4 antibodies and complement. The subsets thus obtained were tested for their potential to lyse LCM virus-infected target cells in vitro and to confer on infected syngeneic recipients the ability to eliminate virus rapidly from their spleens. Both capacities were found to be associated with Lyt-1-2+, L3T4- cells. Previous studies had shown that LCM virus-specific cytotoxicity in vitro as well as reduction of replication of LCM virus in the adoptively immunized mouse requires compatibility at K and/or D of the major histocompatibility complex, and we conclude that clearance of LCM virus from the mouse's spleen is mediated by the subset of T lymphocytes that is functionally characterized as cytotoxic/suppressive.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Assmann-Wischer U,Simon MM,Lehmann-Grube Fdoi
10.1007/BF02124809subject
Has Abstractpub_date
1985-01-01 00:00:00pages
249-56issue
5eissn
0300-8584issn
1432-1831journal_volume
174pub_type
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