The microbiology and treatment of human mastitis.

Abstract:

:Mastitis, which is generally described as an inflammation of breast tissue, is a common and debilitating disease which frequently results in the cessation of exclusive breastfeeding and affects up to 33% of lactating women. The condition is a primary cause of decreased milk production and results in organoleptic and nutritional alterations in milk quality. Recent studies employing culture-independent techniques, including metagenomic sequencing, have revealed a loss of bacterial diversity in the microbiome of mastitic milk samples compared to healthy milk samples. In those infected, the pathogens Staphylococcus aureus, Staphylococcus epidermidis and members of corynebacteria have been identified as the predominant etiological agents in acute, subacute and granulomatous mastitis, respectively. The increased incidence of antibiotic resistance in the causative species is also a key cause of concern for treatment of the disease, thus leading to the need to develop novel therapies. In this respect, probiotics and bacteriocins have revealed potential as alternative treatments.

journal_name

Med Microbiol Immunol

authors

Angelopoulou A,Field D,Ryan CA,Stanton C,Hill C,Ross RP

doi

10.1007/s00430-017-0532-z

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

83-94

issue

2

eissn

0300-8584

issn

1432-1831

pii

10.1007/s00430-017-0532-z

journal_volume

207

pub_type

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