Hepatitis A virus in cell culture. II. Growth characteristics of hepatitis A virus in Frhk-4/R cells.

abstract：:We assessed whether the intracellular bacterium Chlamydia pneumoniae was present in post-mortem brain samples from patients with and without late-onset Alzheimer's disease (AD), since some indirect evidence seems to suggest that infection with the organism might be associated with the disease. Nucleic acids prepared f...

journal_title：Medical microbiology and immunology

authors： Balin BJ,Gérard HC,Arking EJ,Appelt DM,Branigan PJ,Abrams JT,Whittum-Hudson JA,Hudson AP

更新日期：1998-06-01 00:00:00

abstract：:The administration of drugs to inhibit metabolic pathways not only reduces the risk of obesity-induced diseases in humans but may also hamper the replication of different viral pathogens. In order to investigate the value of the US Food and Drug Administration-approved anti-obesity drug orlistat in view of its anti-vi...

journal_title：Medical microbiology and immunology

authors： Ammer E,Nietzsche S,Rien C,Kühnl A,Mader T,Heller R,Sauerbrei A,Henke A

更新日期：2015-12-01 00:00:00

abstract：:Therapeutic vaccination for the treatment of chronic hepatitis B has thus far been unsatisfactory. In this review, we discuss potential new therapeutic vaccination strategies and other immunotherapeutic approaches that aim to achieve efficient restoration of HBV immunity in chronically infected patients. ...

journal_title：Medical microbiology and immunology

authors： Koh S,Bertoletti A

更新日期：2015-02-01 00:00:00

abstract：:The effects of gentamicin on cellular physiology were studied in a total of 9 mammalian cell lines, using the following parameters: cell morphology and viability (cytotoxicity), proliferation, culture medium acidification, lactic acid production, lactate dehydrogenase release, virus susceptibility, and effects on kary...

journal_title：Medical microbiology and immunology

authors： Fischer AB

更新日期：1975-01-01 00:00:00

abstract：:Cytomegaloviruses (CMVs) are large double-stranded DNA viruses that replicate slowly and cause life-long persisting infections in their hosts. To achieve this, the CMVs had to evolve numerous countermeasures against innate and adaptive immune responses. Induction of programmed cell death is one important host defense ...

journal_title：Medical microbiology and immunology

authors： Handke W,Krause E,Brune W

更新日期：2012-11-01 00:00:00

abstract：:TT virus (TTV) is a newly discovered virus from a patient with post-transfusion hepatitis. We investigated the frequency and pathogenesis of TTV infection in children. A semi-nested PCR assay was used to amplify TTV-DNA in serum samples from 254 ambulatory children without liver disease, 20 with hepatitis of unknown e...

journal_title：Medical microbiology and immunology

authors： Iriyama M,Kimura H,Nishikawa K,Yoshioka K,Wakita T,Nishimura N,Shibata M,Ozaki T,Morishima T

更新日期：1999-11-01 00:00:00

abstract：:Vaccination has proven to be one of the best weapons protecting the mankind against infectious diseases. Along with the huge progress in microbiology, numerous highly efficacious and safe vaccines have been produced by conventional technology (cultivation), by the use of molecular biology (genetic modification), or by...

journal_title：Medical microbiology and immunology

authors： Doerr HW,Berger A

更新日期：2014-12-01 00:00:00

abstract：:Convulsions and encephalopathy are common complications of Shiga toxin (Stx)-producing Shigella and enterohemorrhagic Escherichia coli infections. In previous studies, we demonstrated that Stx and lipopolysaccharide (LPS) act in concert to enhance mice sensitivity to pentylenetetrazole (PTZ)-induced seizures via mecha...

journal_title：Medical microbiology and immunology

authors： Yuhas Y,Nofech-Mozes Y,Weizman A,Ashkenazi S

更新日期：2002-03-01 00:00:00

abstract：:Cytomegalovirus vaccine development started in the 1970s with attenuated strains. In the 1980s, one of the strains was shown to be safe and effective in renal transplant patients. Then, attention switched to glycoprotein gB, which was shown to give moderate but transient protection against acquisition of the virus by ...

journal_title：Medical microbiology and immunology

authors： Plotkin S

更新日期：2015-06-01 00:00:00

abstract：:Spleen T lymphocytes from mice undergoing acute infection with lymphocytic choriomeningitis virus (LCM virus) were negatively selected by treatment with anti-Lyt or anti-L3T4 antibodies and complement. The subsets thus obtained were tested for their potential to lyse LCM virus-infected target cells in vitro and to con...

journal_title：Medical microbiology and immunology

authors： Assmann-Wischer U,Simon MM,Lehmann-Grube F

更新日期：1985-01-01 00:00:00

abstract：:Illness and death of mice infected by intracerebral inoculation with lymphocytic choriomeningitis virus are pathologic immune phenomena, and mice thus infected were protected when immunosuppressed with cyclosporin A (CSA), although the virus multiplied extensively in all major organs. Concentrations remained high as l...

journal_title：Medical microbiology and immunology

authors： Löliger C,Lehmann-Grube F

更新日期：1985-01-01 00:00:00

abstract：:Homeostasis underpins at a systems level the regulatory control of immunity and metabolism. While physiologically these systems are often viewed as independent, there is increasing evidence showing a tight coupling between immune and metabolic functions. Critically upon infection, the homeostatic regulation for both i...

journal_title：Medical microbiology and immunology

authors： Kotzamanis K,Angulo A,Ghazal P

更新日期：2015-06-01 00:00:00

abstract：:Enterocytozoon bieneusi is emerging as an important cause of chronic diarrhoea in AIDS patients. Its reservoirs and transmission patterns are unknown. In this study, we have examined E. bieneusi sequences from four Rhesus macaques of different origin, which were kept at one animal facility. The sequences were identica...

journal_title：Medical microbiology and immunology

authors： Drosten C,Laabs J,Kuhn EM,Schottelius J

更新日期：2005-08-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection modulates the host cell cycle to create an environment that is optimal for viral gene expression, DNA replication, and production of infectious virus. The virus mostly infects quiescent cells and thus must push the cell into G1 phase of the cell cycle to co-opt the cellular mecha...

journal_title：Medical microbiology and immunology

authors： Spector DH

更新日期：2015-06-01 00:00:00

abstract：:Quorum sensing system is a cell-to-cell communication system that plays a pivotal role in virulence expression in bacteria. Recent advances have demonstrated that the Pseudomonas aeruginosa quorum sensing molecule, N-3-oxododecanoyl homoserine lactone (3OC(12)-HSL), exerts effects on mammalian cells and modulates host...

journal_title：Medical microbiology and immunology

authors： Li H,Wang L,Ye L,Mao Y,Xie X,Xia C,Chen J,Lu Z,Song J

更新日期：2009-05-01 00:00:00

abstract：:This study describes the properties of an inactivated subunit antigen preparation from varicella-zoster virus (VZV)-infected MRC-5 cells by treatment with detergent and formaldehyde, ultracentrifugation over sucrose and acetone precipitation. The method preserved the antigenicity of VZV proteins and several VZV-specif...

journal_title：Medical microbiology and immunology

authors： Davies J,Hallworth JA,McLeish P,Randall S,Martin BA,Buchan A,Skinner GR

更新日期：1994-05-01 00:00:00

abstract：:Oral treatment of mice with a combination of non-absorbable broad spectrum antibiotics at a dose level high enough to sterilize the digestive tract within five days of treatment, has been found to have a significant negative effect on the relative weight of the thymus. From the age of 12 weeks onwards, the mean relati...

journal_title：Medical microbiology and immunology

authors： van der Waaij D

更新日期：1986-01-01 00:00:00

abstract：:IgG subclass antibodies to Pseudomonas aeruginosa outer membrane proteins (OMP) were investigated in serum from cystic fibrosis (CF) patients by immunoblotting and enzyme-linked immunosorbent assay (ELISA). Fifteen patients (eight in good and seven in poor clinical condition) have been followed for an average of 13 ye...

journal_title：Medical microbiology and immunology

authors： Pressler T,Kronborg G,Shand GH,Mansa B,Høiby N

更新日期：1992-01-01 00:00:00

abstract：:Serum-starved human foreskin fibroblasts were infected by human cytomegalovirus (Towne strain) that is thought to induce DNA replication in host cells during lytic infection. At various times postinfection, the cultures were pulse labeled with either 3H-thymidine or 14C-thymidine and 3H-lysine to examine DNA synthesis...

journal_title：Medical microbiology and immunology

authors： Radsak K,Schmitz B

更新日期：1980-02-01 00:00:00

abstract：:Tests were made on 169 sera from children up to 10 years of age for rotavirus antibodies by indirect immunofluorescence and complement fixation tests. The simian strain SA 11 served as a substitute antigen for the human rotavirus. Furthermore, the SA 11 complement-fixing antigen was compared with a commercial antigen ...

journal_title：Medical microbiology and immunology

authors： Brade L,Schmidt WA

更新日期：1979-03-13 00:00:00

abstract：:Human cytomegalovirus (HCMV) is the most common virus infection in the developing fetus. A fraction of infants infected in utero develop significant life-threatening and organ-threatening disease with over 90% of infected infants exhibiting no clinical evidence of infection in the newborn period. However, about 10% of...

journal_title：Medical microbiology and immunology

authors： Britt W

更新日期：2015-06-01 00:00:00

abstract：:The yeast Candida albicans is part of the microflora in most healthy people, but can become a pathogen when host defenses are compromised. The phenotypic plasticity of C. albicans, which includes switching between different morphologies, contributes to its ability to colonize and infect virtually all body locations. A...

journal_title：Medical microbiology and immunology

authors： Morschhäuser J

更新日期：2010-08-01 00:00:00

abstract：:High titered Clostridium sordellii lethal toxin antiserum, cross-reactive with C. difficile cytotoxin B (ToxB), was used to isolate toxB fragments from a C. difficile expression library. Recombinant clones containing toxB fragments of the 5' and 3' end were isolate. A 2.5-kb HincII fragment of chromosomal DNA overlaps...

journal_title：Medical microbiology and immunology

authors： von Eichel-Streiber C,Laufenberg-Feldmann R,Sartingen S,Schulze J,Sauerborn M

更新日期：1990-01-01 00:00:00

abstract：:Streptomyces globisporus produced an enzyme which had lytic effects on streptococci and was able to solubilize their Fc-receptors. A new method for rapid purification of this enzyme was described. It consisted of adsorption to Amberlite CG 50 and subsequent chromatography on CM-cellulose Whatman CM 52. The purified en...

journal_title：Medical microbiology and immunology

authors： Tille D,Chhatwal GS,Blobel H

更新日期：1986-01-01 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that utilizes the quorum-sensing (QS) process to regulate the production of different virulence factors and biofilm. N-3-oxo-dodecanoyl-L-homoserine lactone (C12) is a key QS molecule of P. aeruginosa which interacts with the mammalian immune cells and modulates thei...

journal_title：Medical microbiology and immunology

authors： Singh PK,Yadav VK,Kalia M,Sharma D,Pandey D,Agarwal V

更新日期：2019-12-01 00:00:00

abstract：:The avirulent Salmonella typhimurium galE strain G30, following oral feeding to mice, developed a state of immunity to a secondary oral challenge with virulent Salmonella typhimurium. This immunity was concommitant with the development of intestinal and serum antibodies and delayed-type hyepersensitivity (DTH) to Salm...

journal_title：Medical microbiology and immunology

authors： Moser I,Hohmann A,Schmidt G,Rowley D

更新日期：1980-01-01 00:00:00

abstract：:The improved Auxotab Enteric I System was re-evaluated and found to correlate 98% with conventional methods for the identification of Enterobacteriaceae. Possible Reasons for previous poor results with this system are discussed. ...

journal_title：Medical microbiology and immunology

authors： Braune LM,Kocka FE

更新日期：1975-07-02 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infections affect 71 million people worldwide, often resulting in severe liver damage. Since 2014 highly efficient therapies based on directly acting antivirals (DAAs) are available, offering cure rates of almost 100%, if the infection is diagnosed in time. It took more than a decade to...

journal_title：Medical microbiology and immunology

authors： Lohmann V

更新日期：2019-02-01 00:00:00

abstract：:A sentinel surveillance system of the public health service for acute respiratory diseases (ARD), especially influenza, has been realized in the Free State of Saxony of Germany for 25 years. The epidemiological sentinel is based on weekly registration of morbidity and mathematical-statistical calculations. For a micro...

journal_title：Medical microbiology and immunology

authors： Bigl S,Briem I,Drechsler R,Kluge D,Müller L,Nowotnik G

更新日期：2002-12-01 00:00:00

abstract：:Gliosis of glial fibrillary acidic protein (GFAP) associated astrocytes is considered to be one of the hallmarks of transmissible spongiform encephalopathies (TSEs). In the present study, remarkable GFAP-PrP(Sc) or GFAP-PrP(C) complexes were separately detected in the brain homogenates of 263 K (Scrapie)-infected or n...

journal_title：Medical microbiology and immunology

authors： Dong CF,Wang XF,Wang X,Shi S,Wang GR,Shan B,An R,Li XL,Zhang BY,Han J,Dong XP

更新日期：2008-12-01 00:00:00