Abstract:
:CAMP factor is an extracellular cytolytic protein produced by Streptococcus agalactiae. CAMP factor has been reported to bind the Fc fragments of immunoglobulin G (IgG) and has therefore also been called protein B, in analogy to protein A of Staphylococcus aureus. We attempted to characterize the interaction of protein B with IgG in more detail. In contrast to protein A, CAMP factor does not inhibit the activation of complement by hemolysin antibodies bound to sheep red cell surfaces. IgG also failed to inhibit the co-hemolytic activity of CAMP factor, which is in disagreement with previous findings. After co-incubation, CAMP factor and IgG were cleanly separated by gel filtration, indicating that no binding had occurred.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
El-Huneidi W,Mui R,Zhang TH,Palmer Mdoi
10.1007/s00430-006-0028-8subject
Has Abstractpub_date
2007-06-01 00:00:00pages
73-7issue
2eissn
0300-8584issn
1432-1831journal_volume
196pub_type
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