Streptococcus agalactiae CAMP factor/protein B does not bind to human IgG.

Abstract:

:CAMP factor is an extracellular cytolytic protein produced by Streptococcus agalactiae. CAMP factor has been reported to bind the Fc fragments of immunoglobulin G (IgG) and has therefore also been called protein B, in analogy to protein A of Staphylococcus aureus. We attempted to characterize the interaction of protein B with IgG in more detail. In contrast to protein A, CAMP factor does not inhibit the activation of complement by hemolysin antibodies bound to sheep red cell surfaces. IgG also failed to inhibit the co-hemolytic activity of CAMP factor, which is in disagreement with previous findings. After co-incubation, CAMP factor and IgG were cleanly separated by gel filtration, indicating that no binding had occurred.

journal_name

Med Microbiol Immunol

authors

El-Huneidi W,Mui R,Zhang TH,Palmer M

doi

10.1007/s00430-006-0028-8

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

73-7

issue

2

eissn

0300-8584

issn

1432-1831

journal_volume

196

pub_type

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