Cloning of Clostridium difficile toxin B gene and demonstration of high N-terminal homology between toxin A and B.

abstract：:Both aging and treated human immunodeficiency virus (HIV) infection are characterized by low-level chronic inflammation and immune activation which contribute to the development of age-related diseases, frailty, and early mortality. Chronic cytomegalovirus (CMV) infection is highly prevalent in older adults and HIV-in...

journal_title：Medical microbiology and immunology

authors： Tavenier J,Margolick JB,Leng SX

更新日期：2019-08-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET format...

journal_title：Medical microbiology and immunology

authors： Lögters T,Margraf S,Altrichter J,Cinatl J,Mitzner S,Windolf J,Scholz M

更新日期：2009-11-01 00:00:00

abstract：:Gliosis of glial fibrillary acidic protein (GFAP) associated astrocytes is considered to be one of the hallmarks of transmissible spongiform encephalopathies (TSEs). In the present study, remarkable GFAP-PrP(Sc) or GFAP-PrP(C) complexes were separately detected in the brain homogenates of 263 K (Scrapie)-infected or n...

journal_title：Medical microbiology and immunology

authors： Dong CF,Wang XF,Wang X,Shi S,Wang GR,Shan B,An R,Li XL,Zhang BY,Han J,Dong XP

更新日期：2008-12-01 00:00:00

abstract：:This study describes the properties of an inactivated subunit antigen preparation from varicella-zoster virus (VZV)-infected MRC-5 cells by treatment with detergent and formaldehyde, ultracentrifugation over sucrose and acetone precipitation. The method preserved the antigenicity of VZV proteins and several VZV-specif...

journal_title：Medical microbiology and immunology

authors： Davies J,Hallworth JA,McLeish P,Randall S,Martin BA,Buchan A,Skinner GR

更新日期：1994-05-01 00:00:00

abstract：:Fifty out of sixty-five isolates of coagulase-negative staphylococci displayed a positive CAMP-reaction due to synergism of an extracellular toxin with S. aureus beta-toxin on sheep erythrocytes. Of the CAMP-positive isolates, 40 were identified as S. epidermidis, 8 as S. hemolyticus, and 2 each as S. hominis and S. s...

journal_title：Medical microbiology and immunology

authors： Bhakdi S

更新日期：1985-01-01 00:00:00

abstract：:A clinical trial was conducted with Alice/R-75 strain live attenuated intranasal influenza A/B vaccine. With double blind control 88 adult volunteers were administered 2 doses of Alice/R-75 vaccine, 93 volunteers received one dose of Alice/R-75 vaccine and one dose placebo solution and 94 subjects were administered 2 ...

journal_title：Medical microbiology and immunology

authors： Spencer MJ,Cherry JD,Powell KR,Sumaya CV

更新日期：1979-03-13 00:00:00

abstract：:Interaction of the nucleocapsid (NP) and V proteins of human parainfluenza type 2 virus (HPIV-2) was investigated using a transient expression system. When the NP proteins were co-expressed with the V proteins, some of the NP proteins were translocated into the nuclei. These findings suggest that the NP protein intera...

journal_title：Medical microbiology and immunology

authors： Watanabe N,Kawano M,Tsurudome M,Nishio M,Ito M,Ohgimoto S,Suga S,Komada H,Ito Y

更新日期：1996-09-01 00:00:00

abstract：:The effect of immune bovine lactoserum (BLS) antipolyvalent enteropathogenic Escherichia coli on bacterial growth, viability and bacteria-induced fluid accumulation was examined in rabbit ileal loops. Human enteropathogenic E. coli strains 0125:K70 (B15), 0111:K58 (B4) and 055:K59 (B5) (1-3 X 10(9) per inoculum) induc...

journal_title：Medical microbiology and immunology

authors： Zinkernagel RM,Colombini A

更新日期：1975-12-30 00:00:00

abstract：:This is a summary of the recent work on some glycosidases of sand flies and their Leishmania parasites. Glycosidases catalyze the hydrolysis of complex sugar subunits of polysaccharides into simple sugars. Leishmania major parasites secrete chitinase and N-acetylglucosaminase, which enables them to survive in the gut ...

journal_title：Medical microbiology and immunology

authors： Jacobson RL,Schlein Y,Eisenberger CL

更新日期：2001-11-01 00:00:00

abstract：:The yeast Candida albicans is part of the microflora in most healthy people, but can become a pathogen when host defenses are compromised. The phenotypic plasticity of C. albicans, which includes switching between different morphologies, contributes to its ability to colonize and infect virtually all body locations. A...

journal_title：Medical microbiology and immunology

authors： Morschhäuser J

更新日期：2010-08-01 00:00:00

abstract：:Upon infection of human T-cell leukemia virus type I (HTLV-I)-carrying human T-cell lines such as MT-4, HTLV-III, a probable etiologic agent of acquired immune deficiency syndrome (AIDS) caused fast and strong cytopathic effects leading ultimately to the death of the cells. Such effects were preceded by the rapid indu...

journal_title：Medical microbiology and immunology

authors： Nakashima H,Koyanagi Y,Harada S,Yamamoto N

更新日期：1986-01-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infections affect 71 million people worldwide, often resulting in severe liver damage. Since 2014 highly efficient therapies based on directly acting antivirals (DAAs) are available, offering cure rates of almost 100%, if the infection is diagnosed in time. It took more than a decade to...

journal_title：Medical microbiology and immunology

authors： Lohmann V

更新日期：2019-02-01 00:00:00

abstract：:Phosphorylcholine (ChoP) is covalently incorporated into bacterial surface structures, contributing to host mimicry and promoting adhesion to surfaces. Our aims were to determine the frequency of ChoP display among Aggregatibacter actinomycetemcomitans strains, to clarify which surface structures bear ChoP, and whethe...

journal_title：Medical microbiology and immunology

authors： Ihalin R,Zhong D,Karched M,Chen C,Asikainen S

更新日期：2018-11-01 00:00:00

abstract：:NFR nude (nu/nu) and euthymic (+/nu) littermates were infected with coxsackievirus B3 (CBV-3) and assayed for virus persistence in the heart, pancreas and spleen, for development of myocarditis and for antibody production. The virus grew to higher titer and persisted longer in hearts of nu/nu mice. In both types of mi...

journal_title：Medical microbiology and immunology

authors： Schnurr DP,Schmidt NJ

更新日期：1984-01-01 00:00:00

abstract：:A new way of measuring indirect immunofluorescence (IIF) of microscopic bacterial slide preparations by videocamera and an image processing system is presented. This method is compared with the conventional method of reading the slides by eye. The advantages of this new approach are objective reading, greater accuracy...

journal_title：Medical microbiology and immunology

authors： Apperloo-Renkema HZ,Wilkinson MH,Oenema DG,van der Waaij D

更新日期：1991-01-01 00:00:00

abstract：:We have studied the incidence of enterotoxigenic and enteropathogenic Escherichia coli strains associated with infant diarrhoeal disease in Galicia (North-west Spain). During a period of 9 months we isolated heat-labile enterotoxin-positive strains in 2.1% of children with diarrhoea examined, whereas the production of...

journal_title：Medical microbiology and immunology

authors： Blanco J,González EA,Bernárdez I,Varela BR

更新日期：1983-01-01 00:00:00

abstract：:Antibody to recombinant hepatitis C virus (HCV) protein C100 (anti-C100) was measured for a period of 6 months by enzyme immunoassay in nine prospectively followed non A-nonB (NANBH) cases which occurred after cardiac surgery at a hospital in Rio de Janeiro (Brazil). At least seven cases were infected with HCV; four o...

journal_title：Medical microbiology and immunology

authors： Yoshida CF,Soares OA,Schatzmayr HG,Uy A,Gerlich WH

更新日期：1992-01-01 00:00:00

abstract：:The DNAs of two kinds of microorganisms from human leprosy lesion, Mycobacterium leprae and Corynebacterium tuberculostearicum (also known as "leprosy-derived corynebacterium" or LDC), have been analysed and compared with the genomes of reference bacteria of the CMN group (genera Corynebacterium, Mycobacterium and Noc...

journal_title：Medical microbiology and immunology

authors： Hottat F,Coene M,Cocito C

更新日期：1988-01-01 00:00:00

abstract：:Tetraspanin (TSPAN) protein family forms a family of transmembrane proteins that act as organizers/scaffold for other proteins. TSPANs are primarily present on plasma membranes although they are also found in other biological membranes. They are organized in tetraspanin-enriched microdomains (TEMs), which allow spatio...

journal_title：Medical microbiology and immunology

authors： Perot BP,Ménager MM

更新日期：2020-08-01 00:00:00

abstract：:Lack of virus-specific cell-mediated immunity (CMI) is associated with worse viral infection outcome in hematopoietic stem cell transplantation (HSCT). We aimed to evaluate the role of immunological monitoring of Epstein-Barr virus (EBV) infection in addition to virological one in 33 adult and 18 pediatric allogeneic ...

journal_title：Medical microbiology and immunology

authors： Chiereghin A,Piccirilli G,Belotti T,Prete A,Bertuzzi C,Gibertoni D,Gabrielli L,Turello G,Borgatti EC,Barbato F,Sessa M,Arpinati M,Bonifazi F,Lazzarotto T

更新日期：2019-12-01 00:00:00

abstract：:Convulsions and encephalopathy are common complications of Shiga toxin (Stx)-producing Shigella and enterohemorrhagic Escherichia coli infections. In previous studies, we demonstrated that Stx and lipopolysaccharide (LPS) act in concert to enhance mice sensitivity to pentylenetetrazole (PTZ)-induced seizures via mecha...

journal_title：Medical microbiology and immunology

authors： Yuhas Y,Nofech-Mozes Y,Weizman A,Ashkenazi S

更新日期：2002-03-01 00:00:00

abstract：:Almost 4000 sera from seven African states were examined for antibodies to ATLV/HTLV-1. Between 1% and 8% of healthy people from sub-Saharan Africa have such antibodies. The highest frequency was observed in Gabon. There were considerable variations between villages. The percentage of seropositives and the mean titre ...

journal_title：Medical microbiology and immunology

authors： Hunsmann G,Bayer H,Schneider J,Schmitz H,Kern P,Dietrich M,Büttner DW,Goudeau AM,Kulkarni G,Fleming AF

更新日期：1984-01-01 00:00:00

abstract：:As enteroviruses are mainly transmitted by the fecal-oral route, this study was initiated to investigate the nature of the binding of enteroviruses to human skin. Using poliovirus 1, Mahoney, we investigated the overall effectiveness of soap and water hand-washing of 1 and 5 min duration. The virus-skin interaction wa...

journal_title：Medical microbiology and immunology

authors： Schürmann W,Eggers HJ

更新日期：1985-01-01 00:00:00

abstract：:The presence of Borna disease virus (BDV)-specific RNA was traced by the reverse transcriptase-polymerase chain reaction in conjunctival fluid, nasal secretions and saliva of horses which were seropositive but did not have any history of clinical Borna disease. Positive reactions encompassed sequences encoding the p24...

journal_title：Medical microbiology and immunology

authors： Richt JA,Herzog S,Haberzettl K,Rott R

更新日期：1993-12-01 00:00:00

abstract：:Antibodies against the human coronavirus OC43 in human sera were measured by haemagglutination inhibition (HI), complement fixation (CF), and radial diffusion-haemolysis in gel (HIG) techniques. The apparent HI titres in a fraction of sera with no antibodies detectable by the two other methods were found to be reduced...

journal_title：Medical microbiology and immunology

authors： Hovi T

更新日期：1978-11-17 00:00:00

abstract：:Cytomegalovirus vaccine development started in the 1970s with attenuated strains. In the 1980s, one of the strains was shown to be safe and effective in renal transplant patients. Then, attention switched to glycoprotein gB, which was shown to give moderate but transient protection against acquisition of the virus by ...

journal_title：Medical microbiology and immunology

authors： Plotkin S

更新日期：2015-06-01 00:00:00

abstract：:IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab')2 domain of IgG, various effector functions become activated via the constant Fcγ part bridging IgG-opsonized targets to FcγR-express...

journal_title：Medical microbiology and immunology

authors： Corrales-Aguilar E,Trilling M,Reinhard H,Falcone V,Zimmermann A,Adams O,Santibanez S,Hengel H

更新日期：2016-10-01 00:00:00

abstract：:Immediate-early (IE) genes are the first genes to be transcribed during the lytic replication cycle of cytomegaloviruses (CMV), and encode nonstructural proteins, which are assumed to have mainly regulatory functions. The IE proteins may play important roles in the pathogenesis of CMV in vivo, for instance during the ...

journal_title：Medical microbiology and immunology

authors： Busche A,Angulo A,Kay-Jackson P,Ghazal P,Messerle M

更新日期：2008-06-01 00:00:00

abstract：:A 33-kDa protein (TB33) was isolated from a delipidated cell sonicate (CS) of Mycobacterium tuberculosis H37Rv (grown in Middlebrook 7H9 broth supplemented with glucose) using immobilized metal affinity chromatography (IMAC) on a nickel-nitrilotriacetic acid (Ni-NTA) column. TB33 could not be isolated from the culture...

journal_title：Medical microbiology and immunology

authors： Deshpande RG,Khan MB,Bhat DA,Navalkar RG

更新日期：1996-11-01 00:00:00

abstract：:Epidemiological studies in Mecklenburg-Vorpommern have shown a high prevalence of Borrelia burgdorferi-infected ticks. A total of 17 B. burgdorferi sensu lato strains were isolated from ticks and investigated by Western blots (immunoblot) with eight monoclonal anti-bodies against different epitopes of the outer surfac...

journal_title：Medical microbiology and immunology

authors： Lottmann H,Wilske B,Herrmann H

更新日期：1996-02-01 00:00:00