Abstract:
:Immediate-early (IE) genes are the first genes to be transcribed during the lytic replication cycle of cytomegaloviruses (CMV), and encode nonstructural proteins, which are assumed to have mainly regulatory functions. The IE proteins may play important roles in the pathogenesis of CMV in vivo, for instance during the establishment of latency and during reactivation. We constructed mouse CMV mutants with disruptions in the major IE genes, ie1 and ie3, to study the roles of these genes in the context of the viral infection. Here we summarize the current results on the characterization of these mutants and give a perspective of the future research in this field.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Busche A,Angulo A,Kay-Jackson P,Ghazal P,Messerle Mdoi
10.1007/s00430-008-0076-3subject
Has Abstractpub_date
2008-06-01 00:00:00pages
233-40issue
2eissn
0300-8584issn
1432-1831journal_volume
197pub_type
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