Abstract:
:Earlier we reported that vaccination of leprosy patients with Mycobacterium w induces an immune response directed predominantly against low molecular weight antigens. One of these antigens, with a molecular mass of 30-kDa, was recognized by a majority of the vaccinated subjects as well as the tuberculoid leprosy patients and healthy contacts. In the present communication we report further characterization of this antigen. Immunofluorescence and Western blot studies with antibodies raised against this antigen demonstrate that it is associated with the cell surface and has homologues present in M. leprae and M. tuberculosis. Delayed-type hypersensitivity studies carried out in guinea pigs immunized with the 30-kDa antigen show that in addition to sharing B cell determinants, this immunodominant antigen of M. w also shares T cell determinants with M. leprae and M. tuberculosis.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Yadava A,Mukherjee Rdoi
10.1007/BF00579623subject
Has Abstractpub_date
1993-11-01 00:00:00pages
243-53issue
5eissn
0300-8584issn
1432-1831journal_volume
182pub_type
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