The clinical value of neutrophil extracellular traps.

Abstract:

:Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET formation and/or decreased NET degradation seems to correlate with disease outcome. This review summarizes current knowledge about the relation of NETs in a broad spectrum of clinical settings. Specifically, we focus on the importance of NETs as a predictive marker in severely ill patients and further, we speculate about the potential pathophysiology of NETs.

journal_name

Med Microbiol Immunol

authors

Lögters T,Margraf S,Altrichter J,Cinatl J,Mitzner S,Windolf J,Scholz M

doi

10.1007/s00430-009-0121-x

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

211-9

issue

4

eissn

0300-8584

issn

1432-1831

journal_volume

198

pub_type

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