Abstract:
:Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET formation and/or decreased NET degradation seems to correlate with disease outcome. This review summarizes current knowledge about the relation of NETs in a broad spectrum of clinical settings. Specifically, we focus on the importance of NETs as a predictive marker in severely ill patients and further, we speculate about the potential pathophysiology of NETs.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Lögters T,Margraf S,Altrichter J,Cinatl J,Mitzner S,Windolf J,Scholz Mdoi
10.1007/s00430-009-0121-xsubject
Has Abstractpub_date
2009-11-01 00:00:00pages
211-9issue
4eissn
0300-8584issn
1432-1831journal_volume
198pub_type
杂志文章,评审abstract::A method for the purification and concentration of Cytomegalovirus nucleocapsids and particles complete with envelope is described. Antibody to either nucleocapsid or envelope antigens can be detected in human sera. In patients with CMV disease the antibodies to the envelope antigen could not be detected before the 3r...
journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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pub_type: 历史文章,杂志文章,评审
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123563
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journal_title:Medical microbiology and immunology
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