Immune response to a recombinant fragment of the CagA protein of Helicobacter pylori in blood donors and patients with gastric cancer: relation to ABO(H) blood group phenotype, stage of the disease and tumor morphology.

Abstract:

:IgG immune response to CagA was evaluated by enzyme-linked imunosorbent assay (ELISA) using a recombinant fragment of CagA as antigen in 171 patients with gastric cancer and 298 blood donors to determine whether it could be related to the ABO(H) blood group phenotype, stage of cancer or tumor morphology. The CagA-ELISA showed a good specificity (93.5%) and sensitivity (88.5%) as compared with immunoblotting for blot CagA-negative and -positive donors. The Helicobacter pylori seropositive blood group A donors revealed the lowest proportion (37.6%) of strong responders to CagA: A

journal_name

Med Microbiol Immunol

authors

Klaamas K,Kurtenkov O,Covacci A,Lipping A,Wadström T

doi

10.1007/s004300050097

keywords:

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

227-32

issue

4

eissn

0300-8584

issn

1432-1831

journal_volume

187

pub_type

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