当前位置： SCI文献检索 > MEDICAL MICROBIOLOGY AND IMMUNOLOGY期刊下所有文献 > Single oral administration of the novel CXCR4 antagonist, KRH-3955, induces an efficient and long-lasting increase of white blood cell count in normal macaques, and prevents CD4 depletion in SHIV-infected macaques: a preliminary study.

Single oral administration of the novel CXCR4 antagonist, KRH-3955, induces an efficient and long-lasting increase of white blood cell count in normal macaques, and prevents CD4 depletion in SHIV-infected macaques: a preliminary study.

Abstract：

:We evaluated the long-term effects of the single oral administration of a new CXCR4 antagonist, KRH-3955, on elevation of white blood cell (WBC), neutrophil and lymphocyte counts in normal cynomolgus monkeys. In the monkeys treated with 0, 2, 20, 200 mg/kg of the compound, WBC, neutrophil and lymphocyte counts increased dramatically at 2 days after treatment. This effect was dose-dependent, and these cell counts remained elevated 15 days after drug treatment. Since neutrophils are the most abundant WBCs in circulation and bone marrow neutrophil exhaustion impairs the response to bacterial infections, it is intriguing to exploit this pharmacological increase of neutrophils as a tool to address its influence on viral infections in vivo. The SHIV infection studies using the SHIV-KS661c/cynomolgus monkey model showed that a single oral administration of KRH-3955 (100 mg/kg) approximately 24 h before virus exposure did not prevent infection, although it did prevent CD4 cell depletion in 3/3 monkeys. Furthermore, single oral administration of the drug 2 weeks before viral exposure rescued CD4 cells in 1/3 monkeys. This prevention of CD4 cell depletion was observed in both blood and lymphoid tissues. These results show that natural course of the SHIV infection is modulated by artificial increase of neutrophils and lymphocytes caused by KRH-3955 in the cynomolgus monkey model.

journal_name

Med Microbiol Immunol

journal_title

Medical microbiology and immunology

authors

Nakasone T,Kumakura S,Yamamoto M,Murakami T,Yamamoto N

doi

10.1007/s00430-012-0254-1

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

175-82

issue

2

eissn

0300-8584

issn

1432-1831

journal_volume

202

pub_type

杂志文章

相关文献

MEDICAL MICROBIOLOGY AND IMMUNOLOGY文献大全
  • Real-time PCR assay and a synthetic positive control for the rapid and sensitive detection of the emerging resistance gene New Delhi Metallo-β-lactamase-1 (bla(NDM-1)).

    abstract：:Carbapenems are important last-line antibiotics for the treatment of hospital infections. Enterobacteriaceae (such as Klebsiella pneumoniae or Escherichia coli) expressing the "New Delhi Metallo-β-lactamase" gene bla(NDM-1) are resistant to carbapenems and were predicted to become a major global health problem. To cop...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-011-0189-y

    authors： Krüttgen A,Razavi S,Imöhl M,Ritter K

    更新日期：2011-05-01 00:00:00

  • Tetraspanin 7 and its closest paralog tetraspanin 6: membrane organizers with key functions in brain development, viral infection, innate immunity, diabetes and cancer.

    abstract：:Tetraspanin (TSPAN) protein family forms a family of transmembrane proteins that act as organizers/scaffold for other proteins. TSPANs are primarily present on plasma membranes although they are also found in other biological membranes. They are organized in tetraspanin-enriched microdomains (TEMs), which allow spatio...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s00430-020-00681-3

    authors： Perot BP,Ménager MM

    更新日期：2020-08-01 00:00:00

  • Nonspecific inhibitors of coronavirus OC43 haemagglutination in human sera.

    abstract：:Antibodies against the human coronavirus OC43 in human sera were measured by haemagglutination inhibition (HI), complement fixation (CF), and radial diffusion-haemolysis in gel (HIG) techniques. The apparent HI titres in a fraction of sera with no antibodies detectable by the two other methods were found to be reduced...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF02121147

    authors： Hovi T

    更新日期：1978-11-17 00:00:00

  • Intrauterine therapy of cytomegalovirus infection with valganciclovir: review of the literature.

    abstract：:Congenital cytomegalovirus (CMV) infection is the leading cause for sensorineural hearing loss and mental retardation in children without genetic diseases worldwide. There is little evidence guiding therapeutic strategies during pregnancy when intrauterine fetal CMV infection is confirmed. We provide a systematic revi...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s00430-017-0512-3

    authors： Seidel V,Feiterna-Sperling C,Siedentopf JP,Hofmann J,Henrich W,Bührer C,Weizsäcker K

    更新日期：2017-10-01 00:00:00

  • Recognition by peptide mapping of three different structural groups of outer membrane protein YOP-1 of Yersinia enterocolitica and Yersinia pseudotuberculosis.

    abstract：:The structural relation of YOP-1 of "european" and "american" Yersinia enterocolitica serotypes O:3, O:9, O:5,27, and O:8 and O:20, respectively, and Y. pseudotuberculosis serotypes I, II, and III was compared by sodium dodecyl sulfate polyacrylamide gel electrophoresis and peptide mapping using Staphylococcus aureus ...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF00215249

    authors： Mack D,Pulz M,Heesemann J

    更新日期：1991-01-01 00:00:00

  • The anti-obesity drug orlistat reveals anti-viral activity.

    abstract：:The administration of drugs to inhibit metabolic pathways not only reduces the risk of obesity-induced diseases in humans but may also hamper the replication of different viral pathogens. In order to investigate the value of the US Food and Drug Administration-approved anti-obesity drug orlistat in view of its anti-vi...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-015-0391-4

    authors： Ammer E,Nietzsche S,Rien C,Kühnl A,Mader T,Heller R,Sauerbrei A,Henke A

    更新日期：2015-12-01 00:00:00

  • Hepatitis A virus in cell culture. II. Growth characteristics of hepatitis A virus in Frhk-4/R cells.

    abstract：:The propagation of hepatitis A virus (HAV) is shown in a rapidly growing fetal rhesus monkey kidney cell line (Frhk-4/R). In the course of ten passages through Frhk-4/R cells the HAV, which was released in the supernatants of the cell cultures, was adapted to these cells. In the tenth passage 6 days after infection, i...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF02122671

    authors： Flehmig B

    更新日期：1981-01-01 00:00:00

  • Live or let die: manipulation of cellular suicide programs by murine cytomegalovirus.

    abstract：:Cytomegaloviruses (CMVs) are large double-stranded DNA viruses that replicate slowly and cause life-long persisting infections in their hosts. To achieve this, the CMVs had to evolve numerous countermeasures against innate and adaptive immune responses. Induction of programmed cell death is one important host defense ...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s00430-012-0264-z

    authors： Handke W,Krause E,Brune W

    更新日期：2012-11-01 00:00:00

  • Comparative study on the immunostimulatory potency of different Propionibacterium strains.

    abstract：:198 strains of Propionibacterium acnes, P. avidum, and P. granulosum were tested for their immunostimulatory potency using splenomegaly as index of stimulation, the activity differed widely from strain to strain. The antitumor and antimetastatic properties of six strains with differing stimulation activities were care...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF02123791

    authors： Ko HL,Roszkowski W,Jeljaszewicz J,Pulverer G

    更新日期：1981-01-01 00:00:00

  • Activation of cord blood myeloid dendritic cells by Trypanosoma cruzi and parasite-specific antibodies, proliferation of CD8+ T cells, and production of IFN-γ.

    abstract：:We previously reported that Trypanosoma cruzi, the agent of Chagas disease, induces in congenitally infected fetuses a strong, adult-like parasite-specific CD8(+) T cell response producing IFN-γ (Hermann et al. in Blood 100:2153-2158, 2002). This suggests that the parasite is able to overcome the immaturity of neonata...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-011-0217-y

    authors： Rodriguez P,Carlier Y,Truyens C

    更新日期：2012-05-01 00:00:00

  • Identification of RNA-binding regions on the P and V proteins of human parainfluenza virus type 2.

    abstract：:We have shown that the P and V proteins of human parainfluenza virus type 2 (hPIV-2) bind to genomic RNA by using Northwestern blot analysis. To identify the RNA-binding regions on the P and V proteins, we used a set of deletion mutants produced in Escherichia coli. One region required for the RNA-binding was found in...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-005-0244-7

    authors： Nishio M,Tsurudome M,Ito M,Ito Y

    更新日期：2006-03-01 00:00:00

  • Interspecies transmission of Enterozytozoon bieneusi supported by observations in laboratory animals and phylogeny.

    abstract：:Enterocytozoon bieneusi is emerging as an important cause of chronic diarrhoea in AIDS patients. Its reservoirs and transmission patterns are unknown. In this study, we have examined E. bieneusi sequences from four Rhesus macaques of different origin, which were kept at one animal facility. The sequences were identica...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-005-0240-y

    authors： Drosten C,Laabs J,Kuhn EM,Schottelius J

    更新日期：2005-08-01 00:00:00

  • The microbiology and treatment of human mastitis.

    abstract：:Mastitis, which is generally described as an inflammation of breast tissue, is a common and debilitating disease which frequently results in the cessation of exclusive breastfeeding and affects up to 33% of lactating women. The condition is a primary cause of decreased milk production and results in organoleptic and n...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s00430-017-0532-z

    authors： Angelopoulou A,Field D,Ryan CA,Stanton C,Hill C,Ross RP

    更新日期：2018-04-01 00:00:00

  • A report of rifampin-resistant leprosy from northern and eastern India: identification and in silico analysis of molecular interactions.

    abstract：:Presence of point mutations within the drug resistance determining regions of Mycobacterium leprae (M. leprae) genome confers molecular basis of drug resistance to dapsone, rifampin and ofloxacin in leprosy. This study is focused on the identification of mutations within the rpoB gene region of M. leprae that are spec...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-014-0354-1

    authors： Vedithi SC,Lavania M,Kumar M,Kaur P,Turankar RP,Singh I,Nigam A,Sengupta U

    更新日期：2015-04-01 00:00:00

  • Early appearance and biphasic kinetics of IgG antibody against hepatitis C virus protein C100-3.

    abstract：:Antibody to recombinant hepatitis C virus (HCV) protein C100 (anti-C100) was measured for a period of 6 months by enzyme immunoassay in nine prospectively followed non A-nonB (NANBH) cases which occurred after cardiac surgery at a hospital in Rio de Janeiro (Brazil). At least seven cases were infected with HCV; four o...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF00191549

    authors： Yoshida CF,Soares OA,Schatzmayr HG,Uy A,Gerlich WH

    更新日期：1992-01-01 00:00:00

  • Abortive growth of human lymphocytes carrying a dormant Epstein-Barr viral genome.

    abstract：:When P3HR-1 lymphoblastoid cells expressing Epstein-Barr virus (EBV)-related antigens at very low frequency were cocultivated with human umbilical cord blood lymphocytes and the cell-free mixed culture fluid was applied to fresh cord lymphocytes, cells morphologically distinct from normal lymphocytes became evident af...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF02125494

    authors： Aya T,Osato T

    更新日期：1978-01-01 00:00:00

  • A membrane-located glycosphingolipid of monocyte/granulocyte lineage cells induces growth arrest and triggers the lytic viral cycle in Epstein-Barr virus genome-positive Burkitt lymphoma lines.

    abstract：:Gangliosides are known to influence cell growth and differentiation. The neolacto series ganglioside IV3NeuAc-nLc4 (2-->3-sialosylparagloboside) is present in members of the monocyte/granulocyte lineage, but is not found in cells that belong to the lymphocyte lineage. In this study we demonstrated that IV3NeuAc-nLc4 i...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s004300050101

    authors： Schaade L,Kleines M,Walter R,Thomssen R,Ritter K

    更新日期：1999-08-01 00:00:00

  • Human papilloma virus (HPV) infection leads to the development of head and neck lesions but offers better prognosis in malignant Indian patients.

    abstract：:Head and neck cancers constitute a multifactorial global disease burden and are associated with human papilloma virus (HPV) as a possible risk factor. The aim of the study is to understand the relationship between HPV and the development of head and neck lesions in Indian patients. To this end, frequency of HPV was as...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-017-0502-5

    authors： Sarkar S,Alam N,Chakraborty J,Biswas J,Mandal SS,Roychoudhury S,Panda CK

    更新日期：2017-06-01 00:00:00

  • Influence of the cultivation, devitalization and preservation of Staphylococcus aureus ATCC 12598 on the activity of cell-bound protein A.

    abstract：:Different culture conditions, devitalizing treatments, and preservation procedures were tested for the production of protein A-bearing cells of Staphylococcus aureus ATCC 12598. Native cells with the highest IgG-binding activity were obtained after cultivation at 37 degrees C for 24-48 h in enriched media. Devitalizat...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF02123683

    authors： Ansorg RA,Zarifoglu FI

    更新日期：1986-01-01 00:00:00

  • An immunodominant 30-kDa antigen of a candidate anti-leprosy vaccine, Mycobacterium w, shares T and B cell determinants with M. leprae and M. tuberculosis.

    abstract：:Earlier we reported that vaccination of leprosy patients with Mycobacterium w induces an immune response directed predominantly against low molecular weight antigens. One of these antigens, with a molecular mass of 30-kDa, was recognized by a majority of the vaccinated subjects as well as the tuberculoid leprosy patie...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF00579623

    authors： Yadava A,Mukherjee R

    更新日期：1993-11-01 00:00:00

  • Involvement of polyphosphate kinase in virulence and stress tolerance of uropathogenic Proteus mirabilis.

    abstract：:Proteus mirabilis (P. mirabilis), a gram-negative enteric bacterium, frequently causes urinary tract infections. Many virulence factors of uropathogenic P. mirabilis have been identified, including urease, flagella, hemolysin and fimbriae. However, the functions of polyphosphate kinase (PPK), which are related to the ...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-015-0430-1

    authors： Peng L,Jiang Q,Pan JY,Deng C,Yu JY,Wu XM,Huang SH,Deng XY

    更新日期：2016-04-01 00:00:00

  • The impact of KIR-HLA genotype on hepatitis B virus clearance in Iranian infected individuals.

    abstract：:Killer cell immunoglobulin like receptors (KIRs) have a principal role in regulating the effector functions of NK cells, particularly in viral infections. The major ligands for KIRs are human leukocyte antigen (HLA) class I molecules. The aim of this study is to investigate the possible association of KIR genes, their...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-017-0522-1

    authors： Shah-Hosseini A,Jafari M,Mohammadi A,Sanaei R,Alavian SM,Doosti-Irani A,Nooradeh Keykavousi M,Tajik N

    更新日期：2017-12-01 00:00:00

  • Cytotoxic effects of a leukocidin from Fusobacterium necrophorum on bovine hepatic cells.

    abstract：:Cytotoxic effects of a leukocidin from Fusobacterium necrophorum were demonstrated on bovine hepatic cells. The cytotoxic response was dose-dependent and could be inhibited by homologous antiserum. Scanning electron microscopy revealed damaged hepatic cell surface. These findings indicated a pathogenic role of the leu...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF00190308

    authors： Ishii T,Kanoe M,Inoue T,Kai K,Blobel H

    更新日期：1988-01-01 00:00:00

  • Experience with the clinical development of influenza vaccines for potential pandemics.

    abstract：:During normal interpandemic influenza seasons, immune responses to vaccines are quite predictable and meet the licensing criteria of the European Union (EU) Committee for Proprietary Medicinal Products (CPMP). In a pandemic situation, large sections, if not all of the community will be immunologically naïve and theref...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-002-0146-x

    authors： Wood JM,Nicholson KG,Stephenson I,Zambon M,Newman RW,Major DL,Podda A

    更新日期：2002-12-01 00:00:00

  • Demonstration of Borna disease virus-specific RNA in secretions of naturally infected horses by the polymerase chain reaction.

    abstract：:The presence of Borna disease virus (BDV)-specific RNA was traced by the reverse transcriptase-polymerase chain reaction in conjunctival fluid, nasal secretions and saliva of horses which were seropositive but did not have any history of clinical Borna disease. Positive reactions encompassed sequences encoding the p24...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF00191945

    authors： Richt JA,Herzog S,Haberzettl K,Rott R

    更新日期：1993-12-01 00:00:00

  • Active immunization with feline leukemia virus envelope glycoprotein suppresses growth of virus-induced feline sarcoma.

    abstract：:The efficiency was examined of immunization with feline leukemia virus glycoprotein complexes (gp85 rosettes) to protect cats against tumors induced by feline sarcoma virus (FeSV). The glycoprotein was isolated from feline leukemia virus (FeLV). Young cats were vaccinated with the purified viral glycoprotein and chall...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF02123497

    authors： Hunsmann G,Pedersen NC,Theilen GH,Bayer H

    更新日期：1983-01-01 00:00:00

  • T-cell immunity against cytomegalovirus in HIV infection and aging: relationships with inflammation, immune activation, and frailty.

    abstract：:Both aging and treated human immunodeficiency virus (HIV) infection are characterized by low-level chronic inflammation and immune activation which contribute to the development of age-related diseases, frailty, and early mortality. Chronic cytomegalovirus (CMV) infection is highly prevalent in older adults and HIV-in...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s00430-019-00591-z

    authors： Tavenier J,Margolick JB,Leng SX

    更新日期：2019-08-01 00:00:00

  • Enhancement of pentylenetetrazole-induced seizures by Shigella dysenteriae in LPS-resistant C3H/HeJ mice: role of the host response.

    abstract：:Convulsions and encephalopathy are common complications of Shiga toxin (Stx)-producing Shigella and enterohemorrhagic Escherichia coli infections. In previous studies, we demonstrated that Stx and lipopolysaccharide (LPS) act in concert to enhance mice sensitivity to pentylenetetrazole (PTZ)-induced seizures via mecha...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-001-0108-8

    authors： Yuhas Y,Nofech-Mozes Y,Weizman A,Ashkenazi S

    更新日期：2002-03-01 00:00:00

  • Interferon induces an antiviral state in ganglioside-deficient transformed mouse fibroblasts.

    abstract：:The antiviral activity of mouse fibroblast interferon against vesicular stomatitis virus was investigated in L-929 mouse fibroblasts and the ganglioside-deficient L-929 mutant cells (ATCC clone NCTC 2071). Although it has been widely reported that gangliosides serve as primary receptors for interferon at the cellular ...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/BF02125527

    authors： Schiffmann D,Koschel K

    更新日期：1981-01-01 00:00:00

  • Alternative Quantiferon cytokines for diagnosis of children with active tuberculosis and HIV co-infection in Ghana.

    abstract：:IFN-γ release assays (IGRAs) often present false-negative or indeterminate results in children with tuberculosis. HIV co-infection may contribute to decreased sensitivity of IGRAs by impairing T-cell IFN-γ expression. Measurement of alternative cytokines in QuantiFERON® (QFT) supernatants can circumvent the IFN-γ-depe...

    journal_title：Medical microbiology and immunology

    pub_type： 杂志文章

    doi：10.1007/s00430-017-0501-6

    authors： Lundtoft C,Awuah AA,Nausch N,Enimil A,Mayatepek E,Owusu-Dabo E,Jacobsen M

    更新日期：2017-06-01 00:00:00