Abstract:
:The aim of this study was to characterize the cytokine secretion patterns of human T helper cells from healthy donors reactive with somatic antigens from various bacteria, the nematode Anisakis and tetanus toxoid. From the peripheral blood of four healthy donors we have established 70 T cell lines reactive with antigens from Yersinia, Salmonella, Morganella, Klebsiella, Serratia, Escherichia, Chlamydia, Shigella, Streptococcus, tetanus toxoid and Anisakis, respectively. Our results show that all T cells reactive with bacteria produce interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), but no interleukin (IL)-4 and no or very little IL-2 and IL-10 and, thus, belong to the Th1 subset, while T cells reactive with tetanus toxoid or Anisakis belong to the Th0 subset with production of IFN-gamma, IL-2, IL-4, IL-10 and TNF-alpha. In summary, our data further substantiate the concept of a functional diversity of human T helper cells with respect to their cytokine profiles. Furthermore, they indicate that a Th1 cytokine profile is not restricted to intracellular bacteria.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Schlaak JF,Nieder P,Meyer zum Büschenfelde KH,Fleischer Bdoi
10.1007/BF00196051subject
Has Abstractpub_date
1994-07-01 00:00:00pages
169-75issue
3eissn
0300-8584issn
1432-1831journal_volume
183pub_type
杂志文章abstract::198 strains of Propionibacterium acnes, P. avidum, and P. granulosum were tested for their immunostimulatory potency using splenomegaly as index of stimulation, the activity differed widely from strain to strain. The antitumor and antimetastatic properties of six strains with differing stimulation activities were care...
journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
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更新日期:2010-08-01 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02121319
更新日期:1976-06-01 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02122671
更新日期:1981-01-01 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
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doi:10.1007/BF00193630
更新日期:1994-02-01 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123802
更新日期:1983-01-01 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-011-0217-y
更新日期:2012-05-01 00:00:00
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journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-012-0264-z
更新日期:2012-11-01 00:00:00