Human T helper cells reactive with somatic bacterial antigens belong to the Th1 subset.

Abstract:

:The aim of this study was to characterize the cytokine secretion patterns of human T helper cells from healthy donors reactive with somatic antigens from various bacteria, the nematode Anisakis and tetanus toxoid. From the peripheral blood of four healthy donors we have established 70 T cell lines reactive with antigens from Yersinia, Salmonella, Morganella, Klebsiella, Serratia, Escherichia, Chlamydia, Shigella, Streptococcus, tetanus toxoid and Anisakis, respectively. Our results show that all T cells reactive with bacteria produce interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), but no interleukin (IL)-4 and no or very little IL-2 and IL-10 and, thus, belong to the Th1 subset, while T cells reactive with tetanus toxoid or Anisakis belong to the Th0 subset with production of IFN-gamma, IL-2, IL-4, IL-10 and TNF-alpha. In summary, our data further substantiate the concept of a functional diversity of human T helper cells with respect to their cytokine profiles. Furthermore, they indicate that a Th1 cytokine profile is not restricted to intracellular bacteria.

journal_name

Med Microbiol Immunol

authors

Schlaak JF,Nieder P,Meyer zum Büschenfelde KH,Fleischer B

doi

10.1007/BF00196051

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

169-75

issue

3

eissn

0300-8584

issn

1432-1831

journal_volume

183

pub_type

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