Abstract:
:9 antigen distribution and sensitivity to the bactericidal effect of normal human serum were determined in 485 Proteus strains isolated from urine, blood, wounds, and feces. Of all strains, 62% could be grouped according to 25 0 antigens. The most frequent one, 0 3, appeared in 13% of all the strains. In blood cultures this antigen was found significantly more often. No other 0 group dominated. Of all strains, 11% were spontaneously agglutinating but such strains were significantly more common in urinary specimens from children with neurogenic bladder disorders. Strains sensitive to the bactericidal effect of normal human serum were significantly more prevalent in urines than in fecal specimens. Most of the sensitive strains were spontaneously agglutinating and were isolated from the urines of children with neurogenic bladder disorders. This may be an example of 'antigenic drift' of the bacteria as a response to host defense mechanisms in the urinary tract.
journal_name
Med Microbiol Immunoljournal_title
Medical microbiology and immunologyauthors
Larsson P,Olling Sdoi
10.1007/BF02121822subject
Has Abstractpub_date
1977-07-18 00:00:00pages
77-82issue
2eissn
0300-8584issn
1432-1831journal_volume
163pub_type
杂志文章abstract::The purpose of this study was to characterize antigenic determinants on structural polypeptides of human immunodeficiency virus type 2 (HIV-2ben). Therefore, three HIV-2-specific monoclonal antibodies (mAbs) against the p24 core protein (gag) and one mAb against the gp130 envelope glycoprotein (env) were produced. In ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00190264
更新日期:1993-07-01 00:00:00
abstract::The prophylactic intranasal medication with a new antiviral compound, 1-phenyl-3-(4 phenyl-2-thiazolyl) guanidine (CL 88,277) was evaluated in humans against rhinovirus 44 challenge. One ml containing 250 mg of CL 88,277 was administered to 10 seronegative volunteers three times a day plus one dose prior to the rhinov...
journal_title:Medical microbiology and immunology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02126707
更新日期:1977-05-18 00:00:00
abstract::The development in rabbits of antibodies against common thermolabile Escherichia coli surface antigens - and against O and K antigens - was investigated. Three strains, E3b (O75:K95:H5), E56b (O8:K27:H-), and H61 (O45:K1:H10), and five rabbits per strain were used. Immunization was carried out by routine procedures us...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02122676
更新日期:1981-01-01 00:00:00
abstract::Escherichia coli isolates of serotype O6:K5 are the most common causative agents of cystitis and pyelonephritis in adults. To answer the question, as to whether strains of this particular serotype represent one special clonal group, out of a collection of 34 serotype O6:K5 isolates [Zingler et al. (1990) Zentralbl. Ba...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00195947
更新日期:1993-03-01 00:00:00
abstract::The antiviral activity of mouse fibroblast interferon against vesicular stomatitis virus was investigated in L-929 mouse fibroblasts and the ganglioside-deficient L-929 mutant cells (ATCC clone NCTC 2071). Although it has been widely reported that gangliosides serve as primary receptors for interferon at the cellular ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02125527
更新日期:1981-01-01 00:00:00
abstract::Industrial and academic needs for innovation and fundamental research are essential and not widely different. Depending on the industrial setting, research and development (R&D) activities may be more focused on the developmental aspects given the need to ultimately sell useful products. However, one of the biggest di...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-019-00643-4
更新日期:2020-06-01 00:00:00
abstract::The infant rat model is widely used to study the pathogenesis of meningitis caused by a variety of gram-positive and gram-negative bacteria. However, the interpretation of published results concerning meningitis is difficult in many records because the fact that blood contamination of the cerebrospinal fluid (CSF) can...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s004300050011
更新日期:1996-05-01 00:00:00
abstract::Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Previous studies have demonstrated that the difference among clinical forms of leprosy can be associated with the immune response of patients, mainly by T helper (Th) and regulatory T cells (Tregs). Then, aiming at clarifying the immune response, ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-017-0519-9
更新日期:2017-12-01 00:00:00
abstract::We assessed whether the intracellular bacterium Chlamydia pneumoniae was present in post-mortem brain samples from patients with and without late-onset Alzheimer's disease (AD), since some indirect evidence seems to suggest that infection with the organism might be associated with the disease. Nucleic acids prepared f...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s004300050071
更新日期:1998-06-01 00:00:00
abstract::Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET format...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-009-0121-x
更新日期:2009-11-01 00:00:00
abstract::The propagation of hepatitis A virus (HAV) is shown in a rapidly growing fetal rhesus monkey kidney cell line (Frhk-4/R). In the course of ten passages through Frhk-4/R cells the HAV, which was released in the supernatants of the cell cultures, was adapted to these cells. In the tenth passage 6 days after infection, i...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02122671
更新日期:1981-01-01 00:00:00
abstract::Surface proteins of nine Campylobacter jejuni strains belonging to three different serovia were extracted with lysozyme/ethylenediamine-tetraacetic acid. The preparations bound to isolated murine small intestinal cells and to a membrane fraction (MF) of isolated brush borders obtained by detergent treatment with Trito...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00202555
更新日期:1989-01-01 00:00:00
abstract::A skim-milk fraction and a whey-protein concentrate (WPC) fraction were prepared from the cows that had been immunized with E. coli isolated from the mouse intestine. The antibacterial effect of these fractions against E. coli was examined. They contained antibody with a high affinity for E. coli strain 48, a represen...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00189427
更新日期:1992-01-01 00:00:00
abstract::Two antigens were isolated from the culture filtrates of H37Ra Mycobacterium tuberculosis by immunoabsorbent affinity chromatography, M. tuberculosis antigen 5 and immunoabsorbent affinity column-purified antigen (IAP). The potential application of these two mycobacterial antigens in the laboratory diagnosis of tuberc...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00193851
更新日期:1991-01-01 00:00:00
abstract::The ability of polymorphonuclear leucocytes (PMNs) from elderly healthy subjects and post-operative cancer patients to ingest and kill Clostridium difficile was studied. The percentage of phagocytosis in clinically healthy subjects aged 69-82 years ranged from 20.2 +/- 3.2 (mean +/- SD) to 34.1 +/- 4.2, depending on t...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02123569
更新日期:1984-01-01 00:00:00
abstract::Human cytomegalovirus (HCMV) infection modulates the host cell cycle to create an environment that is optimal for viral gene expression, DNA replication, and production of infectious virus. The virus mostly infects quiescent cells and thus must push the cell into G1 phase of the cell cycle to co-opt the cellular mecha...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-015-0396-z
更新日期:2015-06-01 00:00:00
abstract::Head and neck cancers constitute a multifactorial global disease burden and are associated with human papilloma virus (HPV) as a possible risk factor. The aim of the study is to understand the relationship between HPV and the development of head and neck lesions in Indian patients. To this end, frequency of HPV was as...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-017-0502-5
更新日期:2017-06-01 00:00:00
abstract::IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab')2 domain of IgG, various effector functions become activated via the constant Fcγ part bridging IgG-opsonized targets to FcγR-express...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-016-0457-y
更新日期:2016-10-01 00:00:00
abstract::The effect of red blood cell age on the susceptibility towards NDV- induced hemolysis has been investigated. It was found that young sheep red blood cells (SRBC), although more resistant to hypotonic hemolysis, are more susceptible towards viral hemolysis than older cells. This may be because young red blood cells hav...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02122855
更新日期:1980-01-01 00:00:00
abstract::Earlier we reported that vaccination of leprosy patients with Mycobacterium w induces an immune response directed predominantly against low molecular weight antigens. One of these antigens, with a molecular mass of 30-kDa, was recognized by a majority of the vaccinated subjects as well as the tuberculoid leprosy patie...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF00579623
更新日期:1993-11-01 00:00:00
abstract::Roizman's definition of herpesviral latency, which applies also to cytomegaloviruses (CMVs), demands maintenance of reactivation-competent viral genomes after clearance of productive infection. It is more recent understanding that failure to complete the productive viral cycle for virus assembly and release does not i...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-019-00615-8
更新日期:2019-08-01 00:00:00
abstract::Adaptation of Borrelia burgdorferi in the vector and vertebrate host is mediated by mechanisms that regulate differential expression of outer surface lipoproteins (Osps). In this study, real time PCR was applied to quantify tissue-specific expression of four linear plasmid (lp54)-encoded (ospA, zs7.a36, zs7.a66 zs7.a6...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-004-0218-1
更新日期:2005-01-01 00:00:00
abstract::Pertussis Toxin (PTx) is one of the most important virulence factors of Bordetella pertussis, the cause of whooping cough. Therefore, the inactivated toxin is an obligatory constituent of acellular pertussis vaccines. It is described in the literature that both native PTx and recombinant Pertussis Toxin (PTg) activate...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-012-0238-1
更新日期:2012-08-01 00:00:00
abstract::The generation of rodent Plasmodium strains expressing fluorescent proteins in all life cycle stages has had a big impact on malaria research. With this tool in hand, for the first time it was possible to follow in real time by in vivo microscopy the infection route of Plasmodium sporozoites transmitted to the mammali...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-007-0044-3
更新日期:2007-09-01 00:00:00
abstract::In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4-6 weeks, followed by ivermectin (IVM) after 6 months. After 6-27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxycycline resulted in ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00430-007-0062-1
更新日期:2008-09-01 00:00:00
abstract::The present study describes the respiratory immune response of mice to locally administered antigen, and the modulation of this response by systemic immunization. Intranasal immunization of mice with the A/PR/8/34 strain of influenza virus evoked local antibody response of the IgA type. The titer of the IgA antibodies...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/BF02121133
更新日期:1978-11-17 00:00:00
abstract::Interactions of virulent Leptospira interrogans with murine monocyte-macrophage-like J774A.1 cells and Vero (African green monkey kidney fibroblasts) cells from attachment to internalization were investigated by a series of morphological analysis. Fontana silver staining revealed that only the pathogenic leptospires w...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-007-0047-0
更新日期:2007-12-01 00:00:00
abstract::Mycobacterium avium subsp. paratuberculosis (MAP) has long been implicated as a triggering agent in Crohn's disease (CD). In this study, we investigated the growth/persistence of both M. avium subsp. hominissuis (MAH) and MAP, in macrophages from healthy controls (HC), CD and ulcerative colitis patients. For viability...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-015-0393-2
更新日期:2015-12-01 00:00:00
abstract::Lack of virus-specific cell-mediated immunity (CMI) is associated with worse viral infection outcome in hematopoietic stem cell transplantation (HSCT). We aimed to evaluate the role of immunological monitoring of Epstein-Barr virus (EBV) infection in addition to virological one in 33 adult and 18 pediatric allogeneic ...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章
doi:10.1007/s00430-019-00629-2
更新日期:2019-12-01 00:00:00
abstract::Varicella during pregnancy can be associated with severe illnesses for both the mother and her neonate. Varicella pneumonia must be regarded as a medical emergency, since pregnant women are at risk of life-threatening ventilatory compromise and death. After maternal chickenpox in the first and second trimesters, conge...
journal_title:Medical microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/s00430-006-0032-z
更新日期:2007-06-01 00:00:00