Neurology and the lupus anticoagulant.

Abstract:

:The lupus anticoagulant, an immunoglobulin of the IgG or IgM class, is one of a group of antiphospholipid antibodies. Although an anticoagulant in vitro, its action in vivo is that of a procoagulant. This procoagulant activity may involve many organ systems including the nervous system. Thus far cerebral thrombosis, spinal thrombosis, chorea and Guillain-Barré syndrome have been described in association with the lupus anticoagulant. Although the lupus anticoagulant is an uncommon cause of neurological disease, it must be considered, especially in a setting of a prolongation of the common pathway of coagulation, thrombosis and other autoimmune phenomena.

journal_name

Eur Neurol

journal_title

European neurology

authors

Englert H,Derue G,Hughes GR

doi

10.1159/000115836

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

422-5

issue

6

eissn

0014-3022

issn

1421-9913

journal_volume

24

pub_type

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