Interleukin-2 production by peripheral blood mononuclear cells from patients with myasthenia gravis.

Abstract:

:We examined interleukin-2 (IL-2) production by phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMs) from 75 untreated myasthenia gravis (MG) patients and 48 control patients. Patients with MG consisted of those with elevated PBM IL-2 production (>1,250 pg/ml; mean + 2SD of the controls) (n = 29, 39%) and those with normal PBM IL-2 production (<1,250 pg/ml) (n = 46, 61%). Significant characteristics of patients with elevated PBM IL-2 production included elevated serum levels of anti-acetylcholine receptor antibodies, severe generalized symptoms, thymic hyperplasia, and marked effects of thymectomy (p < 0.05). These findings suggest that elevated PBM IL-2 production can reflect functional abnormalities of T cells in some patients with MG, and that PBM IL-2 production should be considered as a candidate target of therapy.

journal_name

Eur Neurol

journal_title

European neurology

authors

Utsugisawa K,Nagane Y,Obara D,Kondoh R,Yonezawa H,Tohgi H

doi

10.1159/000069079

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

160-3

issue

3

eissn

0014-3022

issn

1421-9913

pii

69079

journal_volume

49

pub_type

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