Diabetes mellitus in Kearns-Sayre syndrome.

Abstract:

:A 20-year-old woman with Kearns-Sayre syndrome (KSS) suddenly experienced two episodes of diabetic coma. She was studied to determine whether diabetes mellitus (DM) resulted from insulin resistance or from an insulin secretion abnormality, using the euglycemic glucose clamp technique and the glucagon tolerance test. She had a deficiency of insulin secretion from beta cells. It is important to recognize in practice the onset of DM in patients with mitochondrial myopathy. We would suggest that a genetic linkage or mitochondrial dysfunction may be responsible for the association of both disease states.

journal_name

Eur Neurol

journal_title

European neurology

authors

Tanabe Y,Miyamoto S,Kinoshita Y,Yamada K,Sasaki N,Makino E,Nakajima H

doi

10.1159/000116225

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

34-8

issue

1

eissn

0014-3022

issn

1421-9913

journal_volume

28

pub_type

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