Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with infantile spasms.

Abstract:

:Increased levels of lactic dehydrogenase (LDH) in cerebrospinal fluid (CSF) have been reported in association with several intracranial pathologies. We studied LDH isoenzymes in the CSF of children with infantile spasms. CSF samples collected from 12 patients (aged 4-9 months) with infantile spasms were analyzed for total LDH isoenzymes activity, and were compared to samples from 15 normal children. Mean total LDH activity in the CSF was 34.62 +/- 6.52 U/l. Patients with infantile spasms had a lower LDH-1 percentage and higher LDH-3 percentage; the differences from the control group were statistically significant (p < 0.01). LDH-4 and LDH-5 had similar values in both groups. Infantile spasm is apparently associated with a distinct LDH isoenzyme pattern in the CSF. More studies are needed to confirm the rise in LDH-2, LDH-3 and to determine the optimum time of analysis.

journal_name

Eur Neurol

journal_title

European neurology

authors

Nussinovitch M,Harel D,Eidlitz-Markus T,Amir J,Volovitz B

doi

10.1159/000070192

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

231-3

issue

4

eissn

0014-3022

issn

1421-9913

pii

70192

journal_volume

49

pub_type

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