Abstract:
:Increased levels of lactic dehydrogenase (LDH) in cerebrospinal fluid (CSF) have been reported in association with several intracranial pathologies. We studied LDH isoenzymes in the CSF of children with infantile spasms. CSF samples collected from 12 patients (aged 4-9 months) with infantile spasms were analyzed for total LDH isoenzymes activity, and were compared to samples from 15 normal children. Mean total LDH activity in the CSF was 34.62 +/- 6.52 U/l. Patients with infantile spasms had a lower LDH-1 percentage and higher LDH-3 percentage; the differences from the control group were statistically significant (p < 0.01). LDH-4 and LDH-5 had similar values in both groups. Infantile spasm is apparently associated with a distinct LDH isoenzyme pattern in the CSF. More studies are needed to confirm the rise in LDH-2, LDH-3 and to determine the optimum time of analysis.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Nussinovitch M,Harel D,Eidlitz-Markus T,Amir J,Volovitz Bdoi
10.1159/000070192keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
231-3issue
4eissn
0014-3022issn
1421-9913pii
70192journal_volume
49pub_type
杂志文章abstract::The biochemical process underlying Parkinson's disease is dopamine cell death of the nigrostriatal system. The age-dependent cell death is now proposed to be elicited by the formation of free hydroxy radicals which are formed from hydrogen peroxide, a product of oxidation of dopamine by monoamine oxidase, especially t...
journal_title:European neurology
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更新日期:2005-01-01 00:00:00
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doi:10.1159/000115817
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pub_type: 杂志文章
doi:10.1159/000116149
更新日期:1987-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1996-01-01 00:00:00
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更新日期:2001-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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