Abstract:
AIM:To determine the frequency of epilepsies in the family members of epileptic patients. METHODS:The records of 4,851 patients with epilepsy were reviewed. The frequency and patterns of different epilepsies and epileptic syndromes in the patients, number of affected relatives and consanguinity were studied. RESULTS:A total of 1,753 patients were excluded due to various reasons. Of the remaining patients, 296 (9.5% of 3,098) had first- or second-degree relatives affected with seizures. The incidence of family history in the localization-related cryptogenic epilepsies group was significantly higher than all other groups (246 patients). Juvenile myoclonic epilepsy was the most frequent epileptic syndrome (34 patients). Consanguinity was detected in 56 patients, and 33 (58.9%) of these subjects were in the localization-related cryptogenic epilepsies group. Of all subjects, 59 (19.9%) had more than 1 epileptic family member. The ratio of affected first- to second-degree relatives was 202/94. CONCLUSIONS:A considerable number of the relatives of epileptic patients have seizures. The risk of relatives being affected depends on their relationship with the proband. Genetic factors may play an almost equal role in the predisposition of relatives to epilepsy in families of probands with cryptogenic and idiopathic epileptic syndromes.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Sozmen V,Baybas S,Dirican A,Koksal A,Ozturk Mdoi
10.1159/000322125subject
Has Abstractpub_date
2011-01-01 00:00:00pages
4-9issue
1eissn
0014-3022issn
1421-9913pii
000322125journal_volume
65pub_type
杂志文章abstract:BACKGROUND/AIMS:Newer Scandinavian data on intracerebral hemorrhage (ICH) are scarce. We aimed at providing updated community-based data on the incidence, characteristics and outcome of ICH leading to hospitalization in the southernmost region in Norway. METHODS:We analyzed data from all consecutive patients hospitali...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000336299
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very early stage. METHODS:We ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000494261
更新日期:2018-01-01 00:00:00
abstract::Seventy-eight asymptomatic HIV-seropositive (aHIV) subjects were examined by means of an extensive neuropsychological test battery in comparison with 32 HIV-seronegative controls. They were also tested with regard to CD4+ and serum p24 antigen. Fifty-six of them completed a clinical follow-up of 12 up to 36 months and...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117228
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Transient ischemic attacks (TIAs) bear a presumed high risk of early recurrence of stroke. Data in the literature, however, are inconsistent, as recurrence rates range from 9.5 to 20%, at 90 days. AIMS:The study was designed to determine the risk of stroke after TIA. METHODS:94 consecutive patients referre...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000332999
更新日期:2012-01-01 00:00:00
abstract::Superior orbital fissure syndrome is a symptomatologic complex, consisting of retroorbital pain, paralysis of extraocular muscles, impairment of first trigeminal branches and frequent involvement of the optic nerve. From a review of 130 published cases including two personal observations, it appears that the clinical ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114876
更新日期:1977-01-01 00:00:00
abstract::The binding of the dopamine uptake inhibitor [3H]GBR-12935 to postmortem putamen from a control group and patients with Alzheimer's disease/senile dementia of Alzheimer type (AD/SDAT) or vascular dementia (VD) was studied. The binding density (Bmax) in AD/SDAT was significantly reduced to 50% of control. A reduction o...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117341
更新日期:1990-01-01 00:00:00
abstract::The present report evaluates the suppression of antiepileptic drugs in a group of 608 epileptics. Conditions for the suppression of antiepileptic treatment included a previous seizure-free period of 5 years under medication, and a careful evaluation of individual social and work-related circumstances. The reduction of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116141
更新日期:1987-01-01 00:00:00
abstract::The association of anaemia and gastro-intestinal abnormalities with disorders of the brain, spinal cord, and peripheral nerves has been recognized since the mid 19th century. In early reports interpretable as subacute combined degeneration, anaemia was overlooked, and conversely in Addison's and other early reports of...
journal_title:European neurology
pub_type: 历史文章,杂志文章
doi:10.1159/000131715
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:We assessed the, hitherto unknown, impact of intravenous methylprednisolone (ivMP) pulses during relapses of multiple sclerosis (MS) on the kinetics of anti-interferon-beta neutralizing antibodies (Nabs) and binding antibodies (Babs). METHODS:Babs (ELISA) and Nabs (antiviral cytopathic effect assay) ti...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000444319
更新日期:2016-01-01 00:00:00
abstract::Many gadolinium-enhanced magnetic resonance imaging (MRI) studies focusing on the anatomy and pathology of the 7th cranial nerve have already been published. However, only scattered cases of herpes zoster oticus (HZO) have been described and only the MRI appearance of the soft temporal bone structures has been reporte...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000007900
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Effective management of multisymptomatic chronic diseases such as multiple sclerosis (MS) requires a multimodal, interdisciplinary approach. At MS clinics, numerous healthcare specialties are coordinated to provide patients with quality clinical care for all aspects of their disease. Settings and resource av...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000367620
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:ANO10 mutations have recently been reported in autosomal recessive cerebellar ataxia type 3 (ARCA3). The objective of this study was to describe the phenotype of 2 siblings with compound heterozygous ANO10 mutations and progressive cerebellar ataxia, epilepsy, and cognitive impairment. A porencephalic cyst w...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000445109
更新日期:2016-01-01 00:00:00
abstract::The cerebral hemispheres show prominent involvement in hypertensive encephalopathy far more frequently than the brainstem. Two patients with severe paroxysmally accelerated hypertension associated with brainstem hyperintensity in T2-weighted magnetic resonance images are presented. Both present hyperintense lesions im...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000100015
更新日期:2007-01-01 00:00:00
abstract::The effect of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) on blood lymphocytes was studied in multiple sclerosis, patients with acute CNS infections, and healthy controls. No significant differences in lymphocyte proliferation were registered between the group of MS patients and the two other groups, irrespect...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115075
更新日期:1979-01-01 00:00:00
abstract::Calcium ions play a major role in the regulation of cell functions. Minor alterations of the cellular calcium ion homeostasis lead to major functional aberrations. Alterations of the calcium homeostasis occur under conditions of hypoxia, the major cause being an extracellular increase of potassium ions which gate volt...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116059
更新日期:1986-01-01 00:00:00
abstract::A 24-year-old man presented with dystonia, dementia, amyotrophy, choreoathetosis, and ataxia. Partial hexosaminidase A deficiency was documented in serum and leukocytes and confirmed by rectal biopsy with ganglion cells containing membranous cytoplasmic bodies. A brief review of the literature reveals that tremor, dys...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116100
更新日期:1986-01-01 00:00:00
abstract::Clinical evaluation, quantitative analysis of the EMG, and motor unit fiber density were carried out on 34 selected patients that suffered paralytic poliomyelitis. 50% of the subjects developed a late and slowly progressive weakness. Automatic analysis of the electromyogram showed a great increase in mean amplitude in...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115578
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Thalamic lesion due to deep cerebral venous thrombosis (DCVT) is an uncommon cause of stroke. Until now, only a few case reports have been published. The aim of the study is to report the clinical and radiological findings of thalamic lesion with DCVT. METHODS:We reviewed our computerized stroke database of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000439167
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Data on the association between renal dysfunction and outcome in patients with stroke are controversial and scarce. We investigated the predictors of renal dysfunction upon admission and the association between renal dysfunction and clinical outcome in patients with acute stroke in a hospitalized...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000285165
更新日期:2010-01-01 00:00:00
abstract::We report a short-term double-blind, crossover study of CoQ10 in 8 patients with mitochondrial encephalomyopathies. Four patients had myoclonus epilepsy with ragged-red fibers syndrome, 3 had mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes syndrome, and 1 had chronic progressive extern...
journal_title:European neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000117445
更新日期:1997-01-01 00:00:00
abstract::The urinary clearance of pyridostigmine was studied in six patients with myasthenia gravis. In three patients on pyridostigmine alone, renal clearance ranged from 349 to 481 ml/min, corresponding to a pyridostigmine:creatinine clearance ratio of 2.64 to 3.46. In a patient on bendrofluazide as well as pyridostigmine, a...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114882
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND/AIM:In this case-control study, our aim was to check for a possible independent role of hypertension in increasing the risk of developing Bell's palsy. METHODS:All patients diagnosed as having Bell's palsy referred to a neurology clinic were enrolled as cases. Controls were selected among other patients ref...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000151701
更新日期:2008-01-01 00:00:00
abstract::Cavernomas are vascular malformations mostly observed in the central nervous system. They occur in sporadic and familial forms. Familial forms are characterized by the presence of multiple lesions, an autosomal dominant pattern of inheritance and possible de novo lesions. We report two sporadic cases whose follow-up s...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000052100
更新日期:2001-01-01 00:00:00
abstract::In a 14-year follow-up the improvement of language functions and the decrease of EEG abnormalities are described in a girl with the Landau-Kleffner syndrome. In this case, the results of subsequent EEG recordings do not permit conclusions about the course of the aphasia. Disappearance of focal spike and waves, bilater...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116390
更新日期:1989-01-01 00:00:00
abstract:INTRODUCTION:We investigated the predictive value of standard neurological evaluation, a commercially available biomarker assay and neuroimaging in the subacute phase for outcome after thrombolytic therapy in ischemic stroke. METHODS:Thirty-four consecutive ischemic stroke patients were evaluated by means of the NIH S...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000215876
更新日期:2009-01-01 00:00:00
abstract::Although repetitive transcranial magnetic stimulation (rTMS) for hemiparesis is beneficial, so far no study has examined the usefulness of rTMS for apathy. Thirteen patients with chronic stroke were assigned randomly to 2 groups: rTMS group (n = 7) and sham stimulation group (n = 6). The patients received 5 sessions o...
journal_title:European neurology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000477440
更新日期:2017-01-01 00:00:00
abstract::T lymphocytes were determined according to their ability to form rosettes with sheep erythrocytes, in cerebrospinal fluid (CSF) from 120 patients, and in peripheral blood from 59 patients. Normal CSF contained 74.9 +/- 9.6% T lymphocytes. Increased T lymphocyte percentage was found in CSF from patients with active mul...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115074
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:To explore the relationship between metabolic syndrome (MetS) and cognitive impairment in elderly patients with white matter lesions (WML). METHODS:From -January 2016 to June 2017, a cross-sectional study was conducted on the clinical data of 358 WML patients over 65 years old in the Department of Neurology ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000505242
更新日期:2019-01-01 00:00:00
abstract::In 167 patients with cerebrovascular disorders 323 carotid bifurcations were investigated by Duplex ultrasound. In 100 of these patients, additionally intravenous digital subtraction angiography (DSA) was performed and in 35 patients, also intra-arterial DSA was carried out. In 32 patients all three procedures were pe...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116233
更新日期:1988-01-01 00:00:00
abstract::Sir William Gull coined the name 'anorexia nervosa'. Examples of self-starvation appeared in the Hellenistic era. Holy anorexics abused their bodies, rejected marriage and sought religious asylum where many perished and became saints. The condition then paled into obscurity until the 19th century. Louis-Victor Marce (...
journal_title:European neurology
pub_type: 历史文章,杂志文章
doi:10.1159/000082033
更新日期:2004-01-01 00:00:00