Statins provoking MELAS syndrome. A case report.

Abstract:

BACKGROUND:Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. METHODS:We present the case of a patient with mitochondrial syndrome, consisting of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), whose symptoms were temporally related to statin therapy. CONCLUSION:Statins may provoke symptoms related to MELAS in susceptible individuals.

journal_name

Eur Neurol

journal_title

European neurology

authors

Thomas JE,Lee N,Thompson PD

doi

10.1159/000101287

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

232-5

issue

4

eissn

0014-3022

issn

1421-9913

pii

000101287

journal_volume

57

pub_type

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