Normal functional capacity of blood lymphocytes in multiple sclerosis measured by stimulation with mitogens.

Abstract:

:The effect of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) on blood lymphocytes was studied in multiple sclerosis, patients with acute CNS infections, and healthy controls. No significant differences in lymphocyte proliferation were registered between the group of MS patients and the two other groups, irrespective of mitogen used. The ratio between the PWM and PHA responses did not differ significantly from the ratios in the two other groups. The lymphocyte proliferation with PWM was significantly lower in the group with acute CNS infections compared with controls. The results indicate that alterations in cell-mediated immunity, if present in MS, are not confined to lymphocytes outside the CNS.

journal_name

Eur Neurol

journal_title

European neurology

authors

Kinnman J,Link H,Frydén A

doi

10.1159/000115075

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

189-93

issue

3

eissn

0014-3022

issn

1421-9913

journal_volume

18

pub_type

杂志文章
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