Association between the Levels of IL-6, sE-Selectin and Distal Sensory Nerve Conduction Studies in Patients with Prediabetes.

Abstract:

AIM:To determine the association between interleukin-6 (IL-6) and soluble E-selectin (sE-selectin) levels with the electrodiagnostic abnormalities in patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). METHODS:Serum HbA1c, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, IL-6 and sE-selectin levels were analyzed in 25 IFG patients, 22 IGT patients and 41 controls. Nerve conduction studies (NCS) of sural, dorsal sural (DS), medial dorsal cutaneous and medial plantar sensory nerves were conducted. RESULTS:HbA1c and IL-6 levels were significantly higher in IFG and IGT patients than the controls. IGT patients had higher sE-selectin levels compared to controls and IFG patients. IL-6 levels were significantly correlated with levels of CRP, fibrinogen, ESR and sE-selectin in patients with prediabetes. Both IFG and IGT patients had substantial impairments in very distal sensory NCS. IL-6 levels were positively correlated with HbA1c and negatively correlated with DS NCS in prediabetic patients. CONCLUSIONS:Inflammation and endothelial dysfunction might be important in patients with IFG or IGT. Furthermore, our findings strengthen the idea that inflammation (increased levels of IL-6) might be associated with early electrophysiological impairments in patients with prediabetes. NCS of the most distal sensory nerves significantly enhanced the diagnosis of subclinical neuropathy in patients with prediabetes. Subclinical peripheral sensory neuropathy should be investigated in prediabetes to lower the number of future outcomes they are associated with.

journal_name

Eur Neurol

journal_title

European neurology

authors

Tiftikcioglu BI,Duksal T,Bilgin S,Kose S,Zorlu Y

doi

10.1159/000444661

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

124-31

issue

3-4

eissn

0014-3022

issn

1421-9913

pii

000444661

journal_volume

75

pub_type

杂志文章
  • Somatosensory evoked potentials and jerk-locked EEG back-averaging in myoclonic epilepsy.

    abstract::Median nerve somatosensory evoked potentials (SEPs) and jerk-locked EEG back-averaging (JLA) were performed in 2 patients with left-hand myoclonus. Both SEPs were characterized by a normal parietal N20 and an enhanced N27-P27 fronto-parietal complex, but the giant central N40 described by most authors was only observe...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000119509

    authors: Guérit JM,Van den Bergh P,Gobiet Y,Laterre EC

    更新日期:1994-01-01 00:00:00

  • Multiphasic perfusion computed tomography as a predictor of collateral flow in acute ischemic stroke: comparison with digital subtraction angiography.

    abstract:BACKGROUND:Assessing collateral status is important in acute ischemic stroke. The purpose of this study was to compare multiphasic perfusion computed tomography (MPCT) with digital subtraction angiography (DSA) in predicting leptomeningeal collateral flow in acute middle cerebral artery (MCA) infarction. METHODS:Conse...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000334867

    authors: Kim SJ,Noh HJ,Yoon CW,Kim KH,Jeon P,Bang OY,Kim GM,Chung CS,Lee KH

    更新日期:2012-01-01 00:00:00

  • Essential investigations of patients with suspected TIAs.

    abstract::Transient ischemic attacks (TIAs) are warning episodes predicting that such patients are at high risk for stroke which potentially could be life-threatening or leave an individual with substantial disability. TIAs result from large or small vessel disease, cardiogenic embolic events and hematological abnormalities. Th...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000052065

    authors: Anwer UE

    更新日期:1998-01-01 00:00:00

  • Rate of cerebral embolic events in relation to antibiotic and anticoagulant therapy in patients with bacterial endocarditis.

    abstract::To quantitate embolic risk we studied a retrospective series of 61 patients with strictly defined bacterial endocarditis. Eighteen patients had neurological complications attributable to cerebral embolism. Seventeen embolic episodes occurred prior to antibiotic treatment and 8 episodes after its commencement. The rate...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117317

    authors: Paschalis C,Pugsley W,John R,Harrison MJ

    更新日期:1990-01-01 00:00:00

  • Different risk factor profiles between silent brain infarction and symptomatic lacunar infarction.

    abstract:BACKGROUND/AIMS:It is generally assumed that silent brain infarction (SBI) and symptomatic lacunar infarction (sLAC) share common vascular risk factors and their pathogeneses are known to be similar. However, few studies have conducted a risk factor profile analysis of the two diseases in a single study design. METHOD...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000324335

    authors: Kim MH,Moon JS,Park SY,An SA,Kim OJ,Kim NK,Oh SH

    更新日期:2011-01-01 00:00:00

  • Proust, neurology and Stendhal's syndrome.

    abstract::Marcel Proust is one of the most important French writers of the 20th century. His relationship with medicine and with neurology is possibly linked to the fact that his asthma was considered to be a psychosomatic disease classified as neurasthenia. Stendhal's syndrome is a rare psychiatric syndrome characterized by an...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000357562

    authors: Teive HA,Munhoz RP,Cardoso F

    更新日期:2014-01-01 00:00:00

  • The Contribution of Diffusion Tensor Imaging to Quantitative Assessment on Multilevel Cervical Spondylotic Myelopathy.

    abstract:BACKGROUND/AIMS:This study aimed at assessing the feasibility of diffusion tensor imaging (DTI) in multilevel cervical spondylotic myelopathy (MCSM) and quantifying the association between DTI parameters and neuronal status as a whole. METHODS:Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were ob...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000443270

    authors: Ying J,Zhou X,Zhu M,Zhou Y,Huang K,Zhou B,Teng H

    更新日期:2016-01-01 00:00:00

  • Ineffectiveness of folic acid supplementation against phenytoin-induced decrease in salivary immunoglobulin A concentration of epileptic patients.

    abstract:AIMS:This study was designed to investigate if folate treatment is able to reverse the phenytoin-induced deficiency of salivary immunoglobulin A (IgA). METHODS AND MATERIAL:Twenty-five epileptic patients who had been under phenytoin therapy for at least the last 6 months were randomly selected and subjected to folic a...

    journal_title:European neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000121419

    authors: Zare M,Ghazvini MR,Yazdi HR,Nezhad VS,Chitsaz A

    更新日期:2008-01-01 00:00:00

  • Contribution of nerve biopsy to unclassified neuropathy.

    abstract:OBJECTIVES:To evaluate the diagnostic yield of nerve biopsy in patients with peripheral neuropathy of undetermined cause despite extensive diagnostic workup. METHODS:From November 2001 through January 2004, 38 patients underwent nerve biopsy because of unclassified neuropathy. RESULTS:The etiology of the neuropathies...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000098057

    authors: Schweikert K,Fuhr P,Probst A,Tolnay M,Renaud S,Steck AJ

    更新日期:2007-01-01 00:00:00

  • Neurophysiological findings and serum aluminium in dialysis encephalopathy.

    abstract::64 patients on hemodialysis were investigated. The mean duration of dialysis was 43 months. In all the patients, serum aluminium levels, systolic blood pressure (averaged over a period of 6 weeks) and the EEG were investigated. Psychological testing to assess the level of intelligence (IQ) was also performed. The seru...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115500

    authors: Ladurner G,Wawschinek O,Pogglitsch H,Petek W,Urlesberger H,Holzer H

    更新日期:1982-01-01 00:00:00

  • Chorea and polycythaemia.

    abstract::An analysis is presented of 35 cases of chorea as a symptom of polycythaemia. This analysis reveals: (a) whereas polycythaemia occurs predominantly in males (3:2), polycythaemic chorea (PC) occurs predominantly in females (5:2), at a real ratio of female:male = 4:1, the prevalence being 1-2.5% of polycythaemic patient...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000115674

    authors: Bruyn GW,Padberg G

    更新日期:1984-01-01 00:00:00

  • Indications for surgical treatment of cerebrovascular insufficiency.

    abstract::197 cases of patients with CVI, subjected to surgery by carotid endarterectomy, are examined. The results were nearly always good and hence the technique is recommended. Particular interest is attached to the risk connected with carotid clamping, through intraoperative study of CBF with 133Xe, such a risk is practical...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115010

    authors: Fiorani P,Pistolese GR,Faraglia V,Spartera C

    更新日期:1978-01-01 00:00:00

  • Cranial percussion.

    abstract::Percussion of the skull dates from a time when there were virtually no radiological methods for examining the skull and brain. Three apparently independent contributions appeared within the years 1893-1895. The sound elicited, tenderness, and auscultatory percussion have each been employed for diagnostic purposes, but...

    journal_title:European neurology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000115645

    authors: Pearce JM

    更新日期:2008-01-01 00:00:00

  • Medical therapy of cerebral ischemia. Vasoactive and eumetabolic therapy.

    abstract::After briefly evaluating the contraindications and indications of vasoactive and eumetabolic therapy of cerebral ischemia, the paper considers the main drugs at present in use in therapy of the syndrome induced by diffused cerebral arteriosclerosis. Among the drugs with a mainly vasoactive effect, consideration is giv...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115018

    authors: Strano A,Pinto A,Davì G,Novo S,Riolo F

    更新日期:1978-01-01 00:00:00

  • On the legacy of Joseph Babiński.

    abstract::Joseph Babiński pioneered development of French neurosurgery and world clinical neurology. Although he was best known for his discovery of the extensor plantar response, his foundations in the modern semiology of neurology are unequivocal. He introduced the concepts and terminology of cerebellar symptoms and discovere...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000117107

    authors: Gasecki AP,Kwieciński H

    更新日期:1995-01-01 00:00:00

  • Total recovery after bilateral paramedian thalamic infarct.

    abstract::Bilateral paramedian thalamic infarcts are characterised initially by the association of acute vigilance disorders and vertical gaze palsy, followed by persisting dementia with severe mnemic disturbance, global aspontaneity and apathy. We describe a patient with a dramatic neuropsychological recovery, confirmed by tes...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008239

    authors: Krolak-Salmon P,Croisile B,Houzard C,Setiey A,Girard-Madoux P,Vighetto A

    更新日期:2000-01-01 00:00:00

  • Transient ischaemic attack: a common initial manifestation of cardiac myxomas.

    abstract:BACKGROUND AND AIMS:Cardiac myxomas may present clinically with many different features. Since highly effective treatments exist, it is important that they are diagnosed quickly in order to avoid further complications. Our aim was to determine the influence of neurological presentation in diagnosis and prognosis of car...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000052116

    authors: Alvarez-Sabín J,Lozano M,Sastre-Garriga J,Montoyo J,Murtra M,Abilleira S,Codina A

    更新日期:2001-01-01 00:00:00

  • Conduction of electrically elicited impulses in peripheral nerves of diabetic patients.

    abstract::Nerve conduction of single impulses and the ability to transmit frequent trains of stimuli were studied in sensory median and in sural nerves of controls and patients with diabetes mellitus. Decrease of relative amplitudes and increase of relative latencies were more marked in the diabetics as compared with normal con...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115123

    authors: Tackmann W,Lehmann HJ

    更新日期:1980-01-01 00:00:00

  • Type B monoamine oxidase and neurotoxins.

    abstract::The biochemical process underlying Parkinson's disease is dopamine cell death of the nigrostriatal system. The age-dependent cell death is now proposed to be elicited by the formation of free hydroxy radicals which are formed from hydrogen peroxide, a product of oxidation of dopamine by monoamine oxidase, especially t...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000118535

    authors: Naoi M,Maruyama W

    更新日期:1993-01-01 00:00:00

  • Effects of acyclovir on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia in herpes zoster patients.

    abstract::The effect of oral treatment with acyclovir (ACV) on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia (PHN) was studied in 105 patients with herpes zoster. Forty-seven patients were treated with ACV at a dose of 4 g/day in 5 doses for at least a week; the others did not undergo any kind of...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000117274

    authors: Mondelli M,Romano C,Passero S,Porta PD,Rossi A

    更新日期:1996-01-01 00:00:00

  • EEG sleep study in parkinsonian patients under bromocryptine treatment.

    abstract::Nocturnal sleep patterns were registered from 6 parkinsonian patients treated with bromocryptine, ("-Br-L-ergocryptine, C.B.-154) a dopamine-like agonist. No significant differences in their sleep patterns were found in comparison with patients treated with L-dopa. Since bromocryptine acts direct on the dopaminergic r...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114973

    authors: Rabey J,Vardi J,Glaubman H,Streifler M

    更新日期:1978-01-01 00:00:00

  • Cerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment.

    abstract:BACKGROUND:Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. METHODS:This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000315036

    authors: Lyoo CH,Jeong Y,Ryu YH,Rinne JO,Lee MS

    更新日期:2010-01-01 00:00:00

  • Wernicke's disease. A catamnestic study of 50 patients.

    abstract::A catamnestic study of 50 patients with Wernicke's disease showed that nearly all patients retained residual symptoms and that the prognosis as to life expectancy and social functioning was poor, even after early institution of vitamin B-complex medication. It is advisable to give vitamin B-complex prophylactically in...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114797

    authors: Groen RH,Hoff HC

    更新日期:1977-01-01 00:00:00

  • Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia.

    abstract::In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000242010

    authors: Fancellu R,Pareyson D,Corsini E,Salsano E,Laurà M,Bernardi G,Antozzi C,Andreetta F,Colecchia M,Di Donato S,Mariotti C

    更新日期:2009-01-01 00:00:00

  • Hypertrophy of the inferior olivary nucleus in patients with progressive supranuclear palsy.

    abstract::Hypertrophic changes in the inferior olivary nuclei have been occasionally described in patients with progressive supranuclear palsy (PSP). To elucidate the incidence of olivary hypertrophy, we investigated morphologically the olives and their associated pathways in 20 autopsied cases: 11 cases of PSP, 3 cases of Mach...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000007915

    authors: Hanihara T,Amano N,Takahashi T,Itoh Y,Yagishita S

    更新日期:1998-01-01 00:00:00

  • Levodopa-responsive parkinsonism in a patient with Down's syndrome.

    abstract::We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated wi...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117355

    authors: Singer C,Sanchez-Ramos J,Weiner WJ

    更新日期:1990-01-01 00:00:00

  • Diagnostic problems in multiple sclerosis. Two cases with clinical diagnosis of MS showing only a diffusely growing malignant astrocytoma.

    abstract::Two cases are presented with a long clinical history of multiple sclerosis (MS) before the diagnosis of an intracranial brain tumor. In the subsequent brain autopsy, however, both cases presented a diffusely growing anaplastic astrocytoma, only, and no changes similar to MS were seen. Diffuse tumor growth was noted in...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116009

    authors: Röyttä M,Latvala M

    更新日期:1986-01-01 00:00:00

  • Angiographical findings and risk factors in cerebral ischaemia. A retrospective study.

    abstract::Reviewing the angiograms of 100 patients with RIA or stroke we found intracranial lesions in 67%, extracranial lesions in 64%, and normal angiograms in 13% of the cases. Risk factors occurred more often as the angiographic lesions were more extensive. These findings confirm the importance of angiographic examination o...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115177

    authors: van Oudenaarden WF,Tans JT,Hoogland PH

    更新日期:1980-01-01 00:00:00

  • Tumor progression and serum anti-HuD antibody concentration in patients with paraneoplastic neurological syndromes.

    abstract::The aim of this study was to investigate whether there are clues for a correlation between tumor progression and serum anti-Hu antibody concentration in patients with anti-Hu-associated paraneoplastic neurological syndromes (PNS). 19 patients with anti-Hu-associated PNS were assigned to three groups according to the c...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000057897

    authors: Rauer S,Andreou I

    更新日期:2002-01-01 00:00:00

  • Recurrent Fisher's syndrome with immunological abnormalities and replicated laterality.

    abstract::A case of Fisher's syndrome which recurred 10 years apart was reported. Laterality of cranial nerve findings in the initial episode was replicated in the recurrence. Some kind of localized immune sensitization is supposed to play a role in replicating such a laterality. Increased CD4/CD8 ratio and elevated IgE were no...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116688

    authors: Uchihara T,Ikeda M,Tsukagoshi H

    更新日期:1991-01-01 00:00:00