Abstract:
BACKGROUND:Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. METHODS:This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into normal cognition (PD-NC, n = 20), single amnestic (PD-SA, n = 12), single nonamnestic (PD-SN, n = 11), and multidomain MCI (PD-MD, n = 18). Using [(18)F]-fluorodeoxy-glucose PET, cerebral glucose metabolism of MCI groups was compared with that of controls and the PD-NC group. RESULTS:In comparison with controls, PD-NC and PD-SA groups showed no hypometabolic brain areas. However, the PD-SN group showed hypometabolism in parieto-temporo-occipital cortices. The PD-MD group showed widespread hypometabolism that predominantly involved parieto-occipital cortices. In comparison with the PD-NC group, only the PD-MD group showed hypometabolism in lateral frontal, cingulate, and parieto-temporo-occipital cortices. CONCLUSIONS:The distribution of hypometabolic brain areas of the PD-MD group suggests that PD-MD seems to be caused by a common pathology with PD dementia. PD-SA and PD-SN seem to be caused by very mild or topographically heterogeneous cerebral dysfunction. Longitudinal clinical and neuroimaging studies are needed to define whether PD patients with single domain MCI progress to PD-MD and finally to dementia.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Lyoo CH,Jeong Y,Ryu YH,Rinne JO,Lee MSdoi
10.1159/000315036subject
Has Abstractpub_date
2010-01-01 00:00:00pages
65-73issue
2eissn
0014-3022issn
1421-9913pii
000315036journal_volume
64pub_type
杂志文章abstract::A 21-year-old male developed back pain, fever, and rapidly progressive quadriparesis. Lumbar tap yielded frank pus which was confirmed on magnetic resonance imaging (MRI) to be located mainly in the cervical epidural space. Conservative antibiotic remedy was partially effective for restoration of the neurological defi...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116855
更新日期:1992-01-01 00:00:00
abstract::This study assessed gender differences in diabetic patients with ischemic stroke with respect to vascular risk factors, clinical features and early outcome. Ischemic stroke was diagnosed in 261 diabetic women and 300 diabetic men of 2,446 ischemic stroke patients included in a prospective stroke registry over 17 years...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000094249
更新日期:2006-01-01 00:00:00
abstract::To investigate the association between APOE-epsilon4 allele and memory phenotype in the preclinical stage of Alzheimer's disease (AD). We compared an extensive preclinical memory profile at the baseline evaluation of 2 AD genotype groups: APOE-epsilon4 allele carriers and patients with APOE-epsilon3 homozygosity. Base...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000078486
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The coincidence of coronary artery disease (CAD) and carotid artery stenosis (CAS) was observed. However, the association between pre-existing CAD and ischemic stroke (IS) outcome in patients with high-grade CAS remains unclear. We aimed to investigate the association between pre-existing CAD and outcomes of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000512407
更新日期:2020-12-23 00:00:00
abstract:BACKGROUND AND AIMS:Cardiac myxomas may present clinically with many different features. Since highly effective treatments exist, it is important that they are diagnosed quickly in order to avoid further complications. Our aim was to determine the influence of neurological presentation in diagnosis and prognosis of car...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000052116
更新日期:2001-01-01 00:00:00
abstract::To clarify the function of human atrial natriuretic peptide (hANP) in the cerebrospinal fluid (CSF), we examined hANP levels in the CSF of patients with various neurological diseases. The subjects were 16 controls without neurological disease and 45 patients with neurological disease. The 45 patients with neurological...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000113166
更新日期:1997-01-01 00:00:00
abstract::197 cases of patients with CVI, subjected to surgery by carotid endarterectomy, are examined. The results were nearly always good and hence the technique is recommended. Particular interest is attached to the risk connected with carotid clamping, through intraoperative study of CBF with 133Xe, such a risk is practical...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115010
更新日期:1978-01-01 00:00:00
abstract::2 patients with hypoparathyroidism, one idiopathic and the other pseudoform, were studied by overnight polygraphic recording of the sleep EEG and related activities before and after start of treatment to investigate their sleep EEG patterns and states, with the results as follows. (1) Conspicuous abnormalities were no...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115052
更新日期:1979-01-01 00:00:00
abstract::The interpretation of the total phenytoin (PT) concentration can be problematic if valproic acid (VPA) is given as a comedication, because VPA displaces PT from the protein binding sites and can increase the free fraction of PT. In order to estimate the free or unbound PT concentration (PTf) from the total PT concentr...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116647
更新日期:1991-01-01 00:00:00
abstract::The child prodigy Marie-Jean-Pierre Flourens received his medical degree at Montpellier when aged 19. As a young promising physician Flourens was asked to investigate Gall's controversial views on cerebral localization. To test Gall's assertions, Flourens developed ablation as a procedure to explore the workings of th...
journal_title:European neurology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000206858
更新日期:2009-01-01 00:00:00
abstract::MPTP, 1-methyl-4-phenyl-pyridinium ion (MPP+) and the structurally related compounds including N-methyltetrahydroisoquinilinium ion inhibited the tyrosine hydroxylase (TH) system in tissue slices of rat striatum at 10(-5) M. Mouse striatum is more susceptible to MPTP than rat striatum. A similar degree of inhibition b...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116350
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Several treatments are available to treat the immune-mediated chronic inflammatory demyelinating polyneuropathy (CIDP). Among these treatments, intravenous immunoglobulins, corticosteroids and plasma exchanges are validated and widely used. A few immunosuppressive drugs have been tried, but they had little e...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000381767
更新日期:2015-01-01 00:00:00
abstract::Clinicopathological data of a woman with a 3-year course of concurrent amyotrophic lateral sclerosis and dementia are presented. Dementia had occurred at time of onset of motor disturbances and presented as typical frontal lobe dementia. Pathology confirmed motor neuron disease of amyotrophic lateral sclerosis and fro...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000116962
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the plasma levels of factor VIII (FVIII), von Willebrand factor (vWF) and their association in patients with cerebral venous sinus thrombosis (CVST). METHODS:We prospectively included 25 CVST patients admitted to the university hospital and 53 voluntary subjects as a cont...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000331048
更新日期:2011-01-01 00:00:00
abstract::Nocturnal polygraphic recordings (electroencephalography, electro-oculography, submental and intercostal muscle electromyography, electrocardiography, respiration by thoracic strain gauges and oronasal thermistors) with continuous monitoring of arterial oxyhemoglobin saturation by pulse oximeter were performed in 8 pa...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116627
更新日期:1991-01-01 00:00:00
abstract::13 patients with spinal dural arteriovenous fistulas (DAVF) diagnosed in our Institution have been the object of this study. The necessity to include the disease in the differential diagnosis with other pathologies affecting the lower thoracic cord, particularly in middle-aged and old males, is emphasized. Involvement...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117015
更新日期:1994-01-01 00:00:00
abstract::Within non-rapid eye movement sleep, two complementary modalities of arousal organization may be identified: (1) the cyclic alternating pattern (CAP), correlated with successive upward (phase A) and downward (phase B) fluctuations of arousal and arousal-related vegetative functions, and (2) non-CAP, corresponding to a...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117353
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the influence of psychosocial variables on patients with multiple sclerosis (MS) and the relationship between these variables and the onset of MS. BACKGROUND:The current evidence indicates that many types of psychosocial factors are involved in the development and rel...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000226428
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Hypertension and hyperhomocysteinemia (HHcy) are independent risk factors of stroke and are associated with each other. Although evidence suggests that they are related to cognitive impairment, the relationship between hypertension accompanied with HHcy and poststroke cognitive impairment (PSCI) is unclear. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000504704
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Assessing collateral status is important in acute ischemic stroke. The purpose of this study was to compare multiphasic perfusion computed tomography (MPCT) with digital subtraction angiography (DSA) in predicting leptomeningeal collateral flow in acute middle cerebral artery (MCA) infarction. METHODS:Conse...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000334867
更新日期:2012-01-01 00:00:00
abstract::Transient ischemic attacks (TIAs) are warning episodes predicting that such patients are at high risk for stroke which potentially could be life-threatening or leave an individual with substantial disability. TIAs result from large or small vessel disease, cardiogenic embolic events and hematological abnormalities. Th...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000052065
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND/AIM:In this case-control study, our aim was to check for a possible independent role of hypertension in increasing the risk of developing Bell's palsy. METHODS:All patients diagnosed as having Bell's palsy referred to a neurology clinic were enrolled as cases. Controls were selected among other patients ref...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000151701
更新日期:2008-01-01 00:00:00
abstract::The possibility that epileptic seizures and classic migraine episodes may occur in the same patient is discussed. The probable relationship between the neurophysiological mechanisms which underlie both types of attacks has not yet been agreed upon. The case of a young man who suffered from classic migraine and who pre...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115066
更新日期:1979-01-01 00:00:00
abstract::This paper records a patient of Osler's, who showed many features compatible with the Churg-Strauss syndrome of allergic granulomatous angiitis to be described 50 years later. ...
journal_title:European neurology
pub_type: 历史文章,杂志文章
doi:10.1159/000098474
更新日期:2007-01-01 00:00:00
abstract::Here we review a total of 17 patients, including 4 of our own, with young-adult-onset arteriosclerotic leukoencephalopathy, alopecia and lumbago without hypertension. All were Japanese and the illness seemed to be transmitted in an autosomal recessive fashion. The male to female ratio was 7.5:1. The age of onset usual...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000117096
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:We attempted to investigate changes of the pedunculopontine nucleus (PPN) according to walking ability in chronic stroke patients, using diffusion tensor imaging (DTI). METHODS:55 consecutive chronic stroke patients who were not able to walk due to injury of the corticospinal tract (CST) at stroke onset and...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000324152
更新日期:2011-01-01 00:00:00
abstract::A 16-year-old patient presenting with complex partial seizures occurring in the transition from a REM period to wakefulness is described. His baseline EEG showed generalized and symmetrical slow spike and wave complexes, on a normal background activity, activated by NREM sleep. Polygraphic and videotape recordings, ca...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116383
更新日期:1989-01-01 00:00:00
abstract::20 patients who had clinical symptoms and/or signs of compression of the 7th and/or 6th cervical roots were examined. Motor and sensory nerve conduction velocities, velocities in the proximal segment of the median nerve determined by measuring F-wave latencies, cervical somatosensory evoked potentials, and needle elec...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115592
更新日期:1983-01-01 00:00:00
abstract:AIMS:This study was designed to investigate if folate treatment is able to reverse the phenytoin-induced deficiency of salivary immunoglobulin A (IgA). METHODS AND MATERIAL:Twenty-five epileptic patients who had been under phenytoin therapy for at least the last 6 months were randomly selected and subjected to folic a...
journal_title:European neurology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000121419
更新日期:2008-01-01 00:00:00
abstract::Regressive painless left third nerve paralysis with pupillary involvement was followed 6 months later by a right painful complete ophthalmoplegia. The two attacks resolved without treatment. The patient, 22 years old, was recognized diabetic and no other cause was found. It is suggested that this clinical pattern is c...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115554
更新日期:1983-01-01 00:00:00