Ineffectiveness of folic acid supplementation against phenytoin-induced decrease in salivary immunoglobulin A concentration of epileptic patients.

Abstract:

AIMS:This study was designed to investigate if folate treatment is able to reverse the phenytoin-induced deficiency of salivary immunoglobulin A (IgA). METHODS AND MATERIAL:Twenty-five epileptic patients who had been under phenytoin therapy for at least the last 6 months were randomly selected and subjected to folic acid supplementation, 1 mg/day. The salivary IgA concentration of these patients was measured before and after 2 months of folic acid administration and compared with those of 10 healthy individuals. Independent and paired Student's t tests were used to analyze the effects of phenytoin and folic acid, respectively. RESULTS:Salivary IgA levels of patients receiving phenytoin (11.7 +/- 4.8 IU/l) were significantly (p = 0.039) lower than those of healthy controls (14.8 +/- 3.2 IU/l), but did not statistically (p = 0.541) differ from levels (11.8 +/- 4.6 IU/l) measured after 2 months of folic acid supplementation. CONCLUSIONS:According to these results, folic acid supplementation does not seem to have the efficacy to ameliorate phenytoin-induced salivary IgA hyposecretion.

journal_name

Eur Neurol

journal_title

European neurology

authors

Zare M,Ghazvini MR,Yazdi HR,Nezhad VS,Chitsaz A

doi

10.1159/000121419

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

299-301

issue

6

eissn

0014-3022

issn

1421-9913

pii

000121419

journal_volume

59

pub_type

杂志文章,随机对照试验
  • CT techniques.

    abstract::Since the advent of whole-body CT scanning in 1974, many studies have been made in its application to all parts of the body. One of the most fruitful areas has been CT of the spinal cord. The only limitation appears to be the technique used; there is no substitute for a good technique. We shall first review standard C...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115482

    authors: Ledley RS

    更新日期:1982-01-01 00:00:00

  • A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: comparison with Alzheimer's disease.

    abstract::We report a laser microprobe mass analysis of aluminum and iron content in the hippocampus and in the inferior temporal cortex in 2 cases of dementia pugilistica (DP), 4 cases of Alzheimer's disease (AD), and 3 controls. There was a predominant accumulation of Al and Fe within neurofibrillary tangles (NFT) in both DP ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000112903

    authors: Bouras C,Giannakopoulos P,Good PF,Hsu A,Hof PR,Perl DP

    更新日期:1997-01-01 00:00:00

  • Downregulation of striatal dopamine D2 receptors in advanced Parkinson's disease contributes to the development of motor fluctuation.

    abstract::The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson's disease (PD). We used 123I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD,...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000047962

    authors: Hwang WJ,Yao WJ,Wey SP,Shen LH,Ting G

    更新日期:2002-01-01 00:00:00

  • Emerging treatments in dementia.

    abstract::Dementia is one of the most common organic mental syndromes, usually caused by Alzheimer's disease (AD) or vascular dementia (VD) or both. Regarding AD we review the state or the art of the cholinergic approach and discuss some future options regarding preventive and nonsymptomatic strategies. Therapy for VD will cons...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000113372

    authors: Scheltens P,van Gool WA

    更新日期:1997-01-01 00:00:00

  • Renal clearance of pyridostigmine in patients with myasthenia gravis.

    abstract::The urinary clearance of pyridostigmine was studied in six patients with myasthenia gravis. In three patients on pyridostigmine alone, renal clearance ranged from 349 to 481 ml/min, corresponding to a pyridostigmine:creatinine clearance ratio of 2.64 to 3.46. In a patient on bendrofluazide as well as pyridostigmine, a...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114882

    authors: Chan K,Calvey TN

    更新日期:1977-01-01 00:00:00

  • The mechanism of ipsilateral ataxia in lacunar hemiparesis: SPECT perfusion imaging.

    abstract:BACKGROUND AND PURPOSE:Although ataxic hemiparesis is a common lacunar syndrome, the precise mechanism underlying hemiataxia is not clear. We attempted to identify ataxia-related, cerebral blood flow changes in patients presenting with ataxic hemiparesis after acute capsular infarct. METHODS:We used 99mTc-ECD brain pe...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000369009

    authors: Yamamoto R,Johkura K,Nakae Y,Tanaka F

    更新日期:2015-01-01 00:00:00

  • Frontal stroke syndromes.

    abstract::The frontal lobe is the largest lobe of the brain, and it is thus commonly involved in stroke. Moreover, almost one in five strokes is limited to the prerolandic areas. This high frequency of anatomical involvement is in sharp contrast with the apparent rarity of clinical frontal dysfunction in stroke. It is remarkabl...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000117068

    authors: Bogousslavsky J

    更新日期:1994-01-01 00:00:00

  • Refractory epilepsy: a clinically oriented review.

    abstract::About one third of patients with newly diagnosed epilepsy do not achieve seizure control despite medical therapy and should be assessed in detail to confirm the diagnosis, to determine the epilepsy syndrome and to plan treatment strategy. Refractory epilepsy is established when there is inadequate seizure control desp...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000222775

    authors: Beleza P

    更新日期:2009-01-01 00:00:00

  • Effectiveness of low-frequency rTMS and intensive speech therapy in poststroke patients with aphasia: a pilot study based on evaluation by fMRI in relation to type of aphasia.

    abstract:AIM:To assess the safety and clinical efficacy of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) combined with intensive speech therapy (ST) in poststroke patients with aphasia. SUBJECTS AND METHODS:Twenty-four patients with left-hemispheric stroke and aphasia were subjected. During 11-day hospit...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000338773

    authors: Abo M,Kakuda W,Watanabe M,Morooka A,Kawakami K,Senoo A

    更新日期:2012-01-01 00:00:00

  • Development of cerebral infarction shortly after intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Cerebral infarction (CI) occurring soon after intracerebral hemorrhage (ICH) has been rarely reported. The purpose of the present study was to characterize this condition and discuss the possible pathophysiology. METHOD:We retrospectively studied 6 patients who developed CI within 10 days after ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000098465

    authors: Kim CH,Kim JS

    更新日期:2007-01-01 00:00:00

  • T lymphocytes in cerebrospinal fluid from patients with neurological diseases.

    abstract::T lymphocytes were determined according to their ability to form rosettes with sheep erythrocytes, in cerebrospinal fluid (CSF) from 120 patients, and in peripheral blood from 59 patients. Normal CSF contained 74.9 +/- 9.6% T lymphocytes. Increased T lymphocyte percentage was found in CSF from patients with active mul...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115074

    authors: Naess A

    更新日期:1979-01-01 00:00:00

  • Gender differences in coping with tension-type headaches.

    abstract:OBJECTIVE:To study gender differences of coping with illness strategies in tension-type headaches. METHOD:We enrolled 89 subjects (50 women, 39 men) suffering from episodic (n = 37) and chronic (n = 52) tension-type headaches (TTH). Patients were required to answer a Freiburg Questionnaire of Coping with Illness (FQCI...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000072502

    authors: Rollnik JD,Karst M,Piepenbrock S,Gehrke A,Dengler R,Fink M

    更新日期:2003-01-01 00:00:00

  • Sporadic distal myopathy with early adult onset: study of muscle biopsies and muscle cell cultures.

    abstract::A 28-year-old man with negative family history for neuromuscular diseases showed a distal myopathy. Creatine kinase was slightly increased. Two muscle biopsies were performed. The first showed myopathic features, rimmed vacuoles in a limited area and increase of free glycogen; the second showed only nonspecific pathol...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116430

    authors: Mongini T,Doriguzzi C,Palmucci L,Pollo B,Arnaudo E,Bresolin N

    更新日期:1989-01-01 00:00:00

  • Association between the Levels of IL-6, sE-Selectin and Distal Sensory Nerve Conduction Studies in Patients with Prediabetes.

    abstract:AIM:To determine the association between interleukin-6 (IL-6) and soluble E-selectin (sE-selectin) levels with the electrodiagnostic abnormalities in patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). METHODS:Serum HbA1c, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), f...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000444661

    authors: Tiftikcioglu BI,Duksal T,Bilgin S,Kose S,Zorlu Y

    更新日期:2016-01-01 00:00:00

  • Type B monoamine oxidase and neurotoxins.

    abstract::The biochemical process underlying Parkinson's disease is dopamine cell death of the nigrostriatal system. The age-dependent cell death is now proposed to be elicited by the formation of free hydroxy radicals which are formed from hydrogen peroxide, a product of oxidation of dopamine by monoamine oxidase, especially t...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000118535

    authors: Naoi M,Maruyama W

    更新日期:1993-01-01 00:00:00

  • Reports of patients and relatives from the CogniCIS study about cognition in clinically isolated syndrome: what are our patients telling us?

    abstract:OBJECTIVE:To assess the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) in patients with clinically isolated syndrome (CIS). METHODS:130 European CIS patients and 60 relatives completed the MSNQ. RESULTS:The mean (SD) MSNQ score for CIS patients was 15.5 (10.8) and for their informants 11.3 (9.6). Neither ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000345698

    authors: Langdon DW,Benedict RH,Wicklein EM,Beckmann K,Fredrikson S

    更新日期:2013-01-01 00:00:00

  • The Efficacy of High-Frequency Repetitive Transcranial Magnetic Stimulation for Improving Apathy in Chronic Stroke Patients.

    abstract::Although repetitive transcranial magnetic stimulation (rTMS) for hemiparesis is beneficial, so far no study has examined the usefulness of rTMS for apathy. Thirteen patients with chronic stroke were assigned randomly to 2 groups: rTMS group (n = 7) and sham stimulation group (n = 6). The patients received 5 sessions o...

    journal_title:European neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000477440

    authors: Sasaki N,Hara T,Yamada N,Niimi M,Kakuda W,Abo M

    更新日期:2017-01-01 00:00:00

  • William Halse Rivers Rivers (1864-1922) and the sensory nervous system.

    abstract::The polymath William Rivers played an important role in his work with Henry Head in demonstrating the varied, evolving patterns of sensory loss, and epicritic and protopathic sensation, after the section of the superficial ramus of Head's left radial nerve. After a mixed and frustrated army career Rivers devoted his a...

    journal_title:European neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000148693

    authors: Pearce JM

    更新日期:2008-01-01 00:00:00

  • A Phase 3 Multicenter, Prospective, Open-Label Efficacy and Safety Study of Immune Globulin (Human) 10% Caprylate/Chromatography Purified in Patients with Myasthenia Gravis Exacerbations.

    abstract:BACKGROUND:Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular transmission. Exacerbations may involve increasing bulbar weakness and/or sudden respiratory failure, both of which can be critically disabling. Management of MG exacerbations includes plasma exchange and intravenous immunoglobulin (IVI...

    journal_title:European neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000502818

    authors: Karelis G,Balasa R,De Bleecker JL,Stuchevskaya T,Villa A,Van Damme P,Lagrange E,Heckmann JM,Nicolle M,Vilciu C,Bril V,Mondou E,Griffin R,Chen J,Henriquez W,Garcia B,Camprubi S,Ayguasanosa J

    更新日期:2019-01-01 00:00:00

  • Prospective analysis of falls in dominant ataxias.

    abstract::In a previous retrospective study, we demonstrated that falls are common and often injurious in dominant spinocerebellar ataxias (SCAs) and that nonataxia features play an important role in these falls. Retrospective surveys are plagued by recall bias for the presence and details of prior falls. We therefore sought to...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000342907

    authors: Fonteyn EM,Schmitz-Hübsch T,Verstappen CC,Baliko L,Bloem BR,Boesch S,Bunn L,Giunti P,Globas C,Klockgether T,Melegh B,Pandolfo M,Schöls L,Timmann D,van de Warrenburg BP

    更新日期:2013-01-01 00:00:00

  • Hemorheological influences on platelet thrombogenesis.

    abstract::This lecture is mainly concerned with questions about how hemodynamic conditions in atherosclerotic arteries affect arriving platelets that aggregate there and about the chemical agents responsible for making the platelets reactive. The effects of hemodynamic conditions and the agents are known mainly from in vitro ex...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000115608

    authors: Born GV

    更新日期:1983-01-01 00:00:00

  • Oculomotor nerve palsy due to intraneural hemorrhage in idiopathic thrombocytopenic purpura: a case report.

    abstract::We report a 52-year-old man with idiopathic thrombocytopenic purpura accompanying acute oculomotor nerve palsy. At autopsy, intraneural hemorrhage was found in the cavernous portion of the oculomotor nerve. Intraneural bleeding as well as extraneural compression by hematoma formation should be considered as a cause of...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116893

    authors: Miyao S,Takano A,Teramoto J,Fujitake S,Hashizume Y

    更新日期:1993-01-01 00:00:00

  • The Contribution of Diffusion Tensor Imaging to Quantitative Assessment on Multilevel Cervical Spondylotic Myelopathy.

    abstract:BACKGROUND/AIMS:This study aimed at assessing the feasibility of diffusion tensor imaging (DTI) in multilevel cervical spondylotic myelopathy (MCSM) and quantifying the association between DTI parameters and neuronal status as a whole. METHODS:Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were ob...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000443270

    authors: Ying J,Zhou X,Zhu M,Zhou Y,Huang K,Zhou B,Teng H

    更新日期:2016-01-01 00:00:00

  • Mitochondrial abnormalities in a murine model of primary carnitine deficiency. Systemic pathology and trial of replacement therapy.

    abstract::Mitochondrial abnormalities and effectiveness of replacement therapy were examined in a murine model of systemic carnitine deficiency, namely the juvenile visceral steatosis (JVS) mouse. Homozygous JVS mice revealed severe lipid deposition and abnormal mitochondria in liver, heart, skeletal muscle, and kidney, but the...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000113399

    authors: Kaido M,Fujimura H,Ono A,Toyooka K,Yoshikawa H,Nishimura T,Ozaki K,Narama I,Kuwajima M

    更新日期:1997-01-01 00:00:00

  • Angiographical findings and risk factors in cerebral ischaemia. A retrospective study.

    abstract::Reviewing the angiograms of 100 patients with RIA or stroke we found intracranial lesions in 67%, extracranial lesions in 64%, and normal angiograms in 13% of the cases. Risk factors occurred more often as the angiographic lesions were more extensive. These findings confirm the importance of angiographic examination o...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115177

    authors: van Oudenaarden WF,Tans JT,Hoogland PH

    更新日期:1980-01-01 00:00:00

  • Is cerebrospinal fluid spectrophotometry useful in CT scan-negative suspected subarachnoid haemorrage?

    abstract::Missed cerebral aneurysms in CT-negative patients can have serious implications. We set out to determine the usefulness of cerebrospinal fluid (CSF) spectrophotometry and the individual significance of CSF oxyhaemoglobin, bilirubin and methaemoglobin in 463 CT scan-negative patients with suspected subarachnoid haemorr...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000082162

    authors: Gunawardena H,Beetham R,Scolding N,Lhatoo SD

    更新日期:2004-01-01 00:00:00

  • Wernicke's disease. A catamnestic study of 50 patients.

    abstract::A catamnestic study of 50 patients with Wernicke's disease showed that nearly all patients retained residual symptoms and that the prognosis as to life expectancy and social functioning was poor, even after early institution of vitamin B-complex medication. It is advisable to give vitamin B-complex prophylactically in...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114797

    authors: Groen RH,Hoff HC

    更新日期:1977-01-01 00:00:00

  • Wegener's granulomatosis with nervous system involvement: a hospital-based study.

    abstract:BACKGROUND:The aim of this study was to ascertain the clinical manifestations of granulomatosis with polyangiitis (Wegener's) (GPA) with the involvement of the peripheral nervous system (PNS) and central nervous system (CNS). SUMMARY:All neurologic inpatients in a hospital over a 12-year period were reviewed. Nine pat...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000375492

    authors: Huang YH,Ro LS,Lyu RK,Chang HS,Wu YR,Chang KH,Kuo HC

    更新日期:2015-01-01 00:00:00

  • Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia.

    abstract::In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000242010

    authors: Fancellu R,Pareyson D,Corsini E,Salsano E,Laurà M,Bernardi G,Antozzi C,Andreetta F,Colecchia M,Di Donato S,Mariotti C

    更新日期:2009-01-01 00:00:00

  • Gender-specific predictors of functional outcome after stroke rehabilitation: potential role of the autonomic nervous system.

    abstract::The aim of this study was to assess the impact of cardiac autonomic derangement on gender-associated functional outcome of patients with subacute ischemic stroke undergoing a hospital-based rehabilitation program. The study population included 126 consecutive first-ever stroke survivors (mean age 59.7 +/- 11.6 years)....

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000287583

    authors: Bassi A,Colivicchi F,Santini M,Caltagirone C

    更新日期:2010-01-01 00:00:00