Renal clearance of pyridostigmine in patients with myasthenia gravis.

Abstract:

:The urinary clearance of pyridostigmine was studied in six patients with myasthenia gravis. In three patients on pyridostigmine alone, renal clearance ranged from 349 to 481 ml/min, corresponding to a pyridostigmine:creatinine clearance ratio of 2.64 to 3.46. In a patient on bendrofluazide as well as pyridostigmine, a similar clearance ratio was observed. By contrast, the urinary clearance of pyridostigmine and the pyridostigmine:creatinine clearance ratio was reduced in two myasthenic patients concurrently treated with other basic drugs. It is suggested that these results may reflect competition for renal tubular excretion.

journal_name

Eur Neurol

journal_title

European neurology

authors

Chan K,Calvey TN

doi

10.1159/000114882

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

69-72

issue

1-6

eissn

0014-3022

issn

1421-9913

journal_volume

16

pub_type

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