The timing of antiparkinsonian treatment reduction after subthalamic nucleus stimulation.

Abstract:

:The objective of this work was to precisely analyse the reduction of the antiparkinsonian treatment in 18 consecutive patients with Parkinson's disease (PD) operated on for bilateral subthalamic nucleus (STN) stimulation, first after 1 month of follow-up, then at 1 year postoperatively. Trihexyphenidyle, selegiline, entacapone, apomorphine and lisuride could be withdrawn shortly after starting STN electrical stimulation. The levodopa mean daily dose was reduced by 57% at 1 month after surgery and remained stable at 1 year. The mean ropinirole and bromocriptine daily dose decrements after surgery corresponded to 54 and 63%, respectively, at 1 month and to 77 and 40% at 1 year. At 12 months postoperatively, one third of the patients no longer received any antiparkinsonian drugs and the others were on monotherapy of either levodopa or dopamine agonists or received a combined treatment of a dopaminergic agonist and levodopa. In conclusion, STN stimulation allows a major reduction and simplification of antiparkinsonian treatment which can usually be achieved during the early postoperative period.

journal_name

Eur Neurol

journal_title

European neurology

authors

Thobois S,Corvaisier S,Mertens P,Di Guardo C,Mollion H,Guenot M,Rochefort F,Chazot G,Sindou M,Broussolle E

doi

10.1159/000067028

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

59-63

issue

1

eissn

0014-3022

issn

1421-9913

pii

67028

journal_volume

49

pub_type

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