Abstract:
:To examine the possible influence of the blood-CSF barrier function on mathematical formulas for estimating intrathecal IgG production (IgG index, Tourtellotte's formula [TOURT], Schuller and Sagar's formula [Schull], and Reiber and Felgenhauer's formula [IgG(loc)]), we analysed serum and CSF samples from 105 healthy individuals, aged 18-88 years, and 816 consecutive patients without oligoclonal IgG bands (OCBs) in the CSF, aged 18-91 years. In healthy individuals there was no significant correlation between the CSF/serum (S) albumin ratio (i.e. blood-CSF barrier function) and the IgG index, a dimensionless quotient for determining intrathecal IgG production, and only a small correlation (r = -0.08, p < 0.05) in patients without OCBs. However, significant dependence on the blood-CSF barrier function was found, in both healthy individuals and patients without OCBs, for the formulas determining intrathecal IgG production in milligrams (per litre CSF or per day), i.e. for TOURT, SCHULL and IgG(loc). Therefore, we propose a new formula for the quantitative determination of intrathecal IgG production in mg/l, the IGGPROD, which is calculated as: CSF-IgG -[(0.51 x CSF-Alb x S-IgG)/S-Alb]. IGGPROD is an empirical formula, based on findings in 105 healthy individuals 18-88 years of age, and does not depend on the blood CSF barrier function.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Blennow K,Fredman P,Wallin A,Gottfries CG,Skoog I,Wikkelsö C,Svennerholm Ldoi
10.1159/000116920subject
Has Abstractpub_date
1993-01-01 00:00:00pages
134-42issue
2eissn
0014-3022issn
1421-9913journal_volume
33pub_type
杂志文章abstract::Trials of pharmacological intervention for acute stroke show several points of similarity with legal trials by jury. The relationships between sponsoring organisation and regulatory authorities and the roles of the many other participants are described. Only through a partnership can the common aim of developing impro...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000068509
更新日期:2003-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117041
更新日期:1994-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116893
更新日期:1993-01-01 00:00:00
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journal_title:European neurology
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更新日期:1988-01-01 00:00:00
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journal_title:European neurology
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更新日期:1994-01-01 00:00:00
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doi:10.1159/000101287
更新日期:2007-01-01 00:00:00
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journal_title:European neurology
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更新日期:2009-01-01 00:00:00
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journal_title:European neurology
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doi:10.1159/000115123
更新日期:1980-01-01 00:00:00
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更新日期:1989-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000116076
更新日期:1986-01-01 00:00:00
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更新日期:2003-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000332999
更新日期:2012-01-01 00:00:00
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journal_title:European neurology
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更新日期:1977-01-01 00:00:00
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更新日期:1983-01-01 00:00:00
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journal_title:European neurology
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更新日期:1999-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章,评审
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更新日期:1984-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114963
更新日期:1978-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:European neurology
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更新日期:1983-01-01 00:00:00
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journal_title:European neurology
pub_type: 杂志文章,撤回出版物
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