Blood Pressure Variability in Acute Ischemic Stroke: Influence of Infarct Location in the Insular Cortex.

Abstract:

BACKGROUND:The aim of this study was to elucidate the influence of insular infarction on blood pressure (BP) variability and outcomes according to the region of the insular cortex affected. METHODS:A total of 90 patients diagnosed with acute unilateral ischemic stroke were registered. The BP variability was calculated over 24 h after admission (hyperacute) and for 2-3 days after admission (acute). Patients were classified into groups of right and left, and then right anterior, right posterior, left anterior, and left posterior insular infarction. RESULTS:Patients with insular infarction showed a significantly larger infarct volume, higher modified Rankin scale scores, and lower SD and coefficient of variation (CV) of -systolic BP in the hyperacute phase than shown by patients without insular infarction (p < 0.01, p < 0.01, p = 0.02, and p = 0.03, respectively). The SD and CV of systolic BP in the hyperacute phase showed significant differences among the 3 groups with right insular infarction, with left insular infarction, and without insular infarction (p < 0.05 and p < 0.05, respectively). There was a tendency for the systolic BP variability to be lower in patients with right anterior insular infarction than in patients with infarcts in other areas. CONCLUSION:The right insular cortex, especially the anterior part, might be a hub for autonomic nervous regulation.

journal_name

Eur Neurol

journal_title

European neurology

authors

Kitamura J,Ueno H,Nagai M,Hosomi N,Honjo K,Nakamori M,Mukai T,Imamura E,Nezu T,Aoki S,Ohshita T,Nomura E,Wakabayashi S,Maruyama H,Matsumoto M

doi

10.1159/000486306

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

90-99

issue

1-2

eissn

0014-3022

issn

1421-9913

pii

000486306

journal_volume

79

pub_type

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