Abstract:
:L-Dopa pioneered the symptomatic therapy of Parkinson's disease. While this treatment proved effective in the treatment of parkinsonian akinesia, rigidity and tremor, prolonged L-dopa treatment was often noted to result in dyskinesia, psychosis and 'on-off' phenomena. This increasing disability of L-Dopa-treated parkinsonian patients, however, is not correlated with the duration of L-dopa treatment. Mortality due to Parkinson's disease has decreased significantly after the introduction of L-dopa treatment. The development of D1-selective dopamine agonists and the introduction of neuroprotective rather than symptomatic therapy are required for treating Parkinson's disease.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Kuno Sdoi
10.1159/000119537subject
Has Abstractpub_date
1994-01-01 00:00:00pages
17-9eissn
0014-3022issn
1421-9913journal_volume
34 Suppl 3pub_type
杂志文章abstract:PRIMARY OBJECTIVE:To determine whether the ipsilateral cortex surrounding the lesion or the non-injured contralateral cortex is important for motor recovery after brain damage in the photochemically initiated thrombosis (PIT) model. RESEARCH DESIGN:We induced PIT in the sensorimotor cortex in rats and examined the rec...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000095700
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Neurosyphilis (NS) is nowadays a less frequent disease. Its incidence and clinical spectrum have changed over time. OBJECTIVE:To estimate the incidence of NS and describe the clinical spectrum of NS in immunocompetent patients in the last decade. METHODS:Demographic and clinical features, cerebrospinal flu...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000079391
更新日期:2004-01-01 00:00:00
abstract::3 out of 24 patients with mitral valve prolapse (MVP), mean age 25.7 +/- 3.1 displayed markedly thickened redundant and shaggy mitral leaflets in the two-dimensional echocardiogram. The anterior leaflet appeared in the parasternal long axis plane club-shaped in diastole. These three female patients had a history of is...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115766
更新日期:1985-01-01 00:00:00
abstract::Patients suffering from migraine, tension-type headache (TTH), or combined headache (CH) are at risk of developing drug-induced headache (DIH) due to regular use of analgesics, ergot alkaloids, and triptans. The aim of our study was to determine (1) the clinical features of DIH, (2) the outcome of withdrawal therapy u...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000052134
更新日期:2001-01-01 00:00:00
abstract::SJL/J mice have been studied as the model animals for autoimmunological diseases. Recently it was clarified that SJL/J mice have a defect of dysferlin. Human limb girdle muscular dystrophy 2B and Miyoshi myopathy also have a defect of dysferlin. In this study we present the histological and immunohistological changes ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000097005
更新日期:2007-01-01 00:00:00
abstract::The lupus anticoagulant, an immunoglobulin of the IgG or IgM class, is one of a group of antiphospholipid antibodies. Although an anticoagulant in vitro, its action in vivo is that of a procoagulant. This procoagulant activity may involve many organ systems including the nervous system. Thus far cerebral thrombosis, s...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115836
更新日期:1985-01-01 00:00:00
abstract::It is generally believed that a homonymous defect of macular vision (HMV) is caused by a small lesion restricted to the occipital lobe tip and rarely results from ischemic stroke. The incidence of HMV was studied retrospectively in 54 patients with infarction of the posterior cerebral artery territory who underwent Go...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000050785
更新日期:2001-01-01 00:00:00
abstract::Marcel Proust is one of the most important French writers of the 20th century. His relationship with medicine and with neurology is possibly linked to the fact that his asthma was considered to be a psychosomatic disease classified as neurasthenia. Stendhal's syndrome is a rare psychiatric syndrome characterized by an...
journal_title:European neurology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000357562
更新日期:2014-01-01 00:00:00
abstract::In 128 patients with multiple sclerosis (MS) and 204 blood donors (control persons) the in vitro activation of 'Ficoll-purified' peripheral blood T lymphocytes was measured using the 3H-thymidine incorporation rate without (spontaneous proliferation) and with mitogen addition (concanavalin A, phytohemagglutinin). Mito...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116228
更新日期:1988-01-01 00:00:00
abstract::A 9-year-old girl with huge, double arachnoid cysts at the cerebellopontine angle is reported. After a cyst-peritoneal shunt operation, she developed fine, high-frequency gaze nystagmus towards the lesion side combined with coarse, large amplitude nystagmus in the opposite direction, which is the reverse of the Bruns'...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116903
更新日期:1993-01-01 00:00:00
abstract::The interpretation of the total phenytoin (PT) concentration can be problematic if valproic acid (VPA) is given as a comedication, because VPA displaces PT from the protein binding sites and can increase the free fraction of PT. In order to estimate the free or unbound PT concentration (PTf) from the total PT concentr...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116647
更新日期:1991-01-01 00:00:00
abstract::A 48-year-old woman was referred from Zaire with suspected rabies encephalitis. Survival was 34 days after the onset of symptoms and the diagnosis of rabies was ultimately proven after brain autopsy. Serial neurophysiological investigations, including EEG and multimodality evoked potentials and radiological examinatio...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116939
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND/AIMS:It is generally assumed that silent brain infarction (SBI) and symptomatic lacunar infarction (sLAC) share common vascular risk factors and their pathogeneses are known to be similar. However, few studies have conducted a risk factor profile analysis of the two diseases in a single study design. METHOD...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000324335
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Evaluation for surgical treatment is offered to patients who do not respond to antiepileptic drugs. Pseudo-pharmacoresistance (PPR) has been described in the context of impaired compliance, incorrect diagnosis of epilepsy or pharmacological interference resulting in too low blood levels. We were interested to...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000479003
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Parkinson's disease (PD) is commonly characterized by its motor symptoms such as resting tremor, rigidity, bradykinesia and postural instability; however, some of the most debilitating symptoms of this disease are non-motor ones such as dementia and sialorrhea (drooling). Drooling is caused by impaired swall...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000348571
更新日期:2013-01-01 00:00:00
abstract::The biochemical process underlying Parkinson's disease is dopamine cell death of the nigrostriatal system. The age-dependent cell death is now proposed to be elicited by the formation of free hydroxy radicals which are formed from hydrogen peroxide, a product of oxidation of dopamine by monoamine oxidase, especially t...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000118535
更新日期:1993-01-01 00:00:00
abstract::Report on a series of patients suffering from cerebrovascular insufficiency caused by stenosis and/or occlusion of one or several major cerebral vessels. The patients were divided in two groups, one being medically treated with anticoagulants, the other operated on either a carotid artery thrombosis by thromboendarter...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115140
更新日期:1980-01-01 00:00:00
abstract::Petit mal absences in childhood are often followed by grand mal seizures in adolescence and a coexistence of both types of seizures is not uncommon at all. It is noteworthy, however, that such a coexistence does not imply immediate transition from one type of seizure into the other one. Hence, a grand mal attack may b...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114721
更新日期:1976-01-01 00:00:00
abstract:AIMS:To perform a large and detailed epidemiologic study on restless legs syndrome (RLS) during pregnancy in a European country. METHODS:A cross-sectional questionnaire survey. The questionnaire was distributed by the medical staff in different outpatient waiting rooms (obstetrics and gynecology department of the univ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000321413
更新日期:2010-01-01 00:00:00
abstract::The binding of the dopamine uptake inhibitor [3H]GBR-12935 to postmortem putamen from a control group and patients with Alzheimer's disease/senile dementia of Alzheimer type (AD/SDAT) or vascular dementia (VD) was studied. The binding density (Bmax) in AD/SDAT was significantly reduced to 50% of control. A reduction o...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117341
更新日期:1990-01-01 00:00:00
abstract::The blink reflex and its equivalent glabella tap reflex are behavioural motor responses normally found in neonates and in the physiological startle reflex. Historically, it was described by Overend in 1896 and soon afterwards by McCarthy and by Bekhterev who disputed its origins. Kugelberg in 1952 recorded the early-l...
journal_title:European neurology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000114053
更新日期:2008-01-01 00:00:00
abstract::A catamnestic study of 50 patients with Wernicke's disease showed that nearly all patients retained residual symptoms and that the prognosis as to life expectancy and social functioning was poor, even after early institution of vitamin B-complex medication. It is advisable to give vitamin B-complex prophylactically in...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114797
更新日期:1977-01-01 00:00:00
abstract::The effect of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) on blood lymphocytes was studied in multiple sclerosis, patients with acute CNS infections, and healthy controls. No significant differences in lymphocyte proliferation were registered between the group of MS patients and the two other groups, irrespect...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115075
更新日期:1979-01-01 00:00:00
abstract::A 39-year-old intravenous drug user presented with dysarthria and a syndrome of the left cerebellar hemisphere. While in hospital, he developed progressive brainstem findings. Repeated CT scans revealed a lucency in the white matter of the left cerebellar hemisphere. Brainstem auditory and short-latency somatosensory ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116280
更新日期:1988-01-01 00:00:00
abstract::Reduction in caeruloplasmin (Cp) levels is sometimes found in other sporadic movement disorders, not limited to Wilson's disease (WD). Serum levels of Cp, copper, iron and gamma-glutamyl transpeptidase were measured in 71 patients with various diagnoses of movement disorders, including Parkinson's disease (PD), atypic...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000330538
更新日期:2011-01-01 00:00:00
abstract::The effect of thoracic duct lymph drainage (5-34 days) in 12 patients with myasthenia gravis on muscular function has been followed for 5-43 months. Among the results obtained were: (1) During the drainage the myasthenic symptoms decreased markedly after 1-4 days and remained so during the drainage. (2) The doses of c...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114659
更新日期:1975-01-01 00:00:00
abstract:AIM:To investigate whether writing errors are predictive of longitudinal brain atrophy progression in patients with amyotrophic lateral sclerosis (ALS). METHODS:The frequency of writing errors in 6 ALS patients without dementia was compared with longitudinal changes in lateral ventricular areas of the bilateral anteri...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000328216
更新日期:2011-01-01 00:00:00
abstract::In a group of 60 patients of which 30 were affected by myasthenia, we used the regional curare test. The results were evaluated from a critical point of view and were then compared with the results obtained by the repetitive stimulation of the circumflex nerve, deriving from deltoid muscle. We considered too the speci...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114813
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND/AIM:In this case-control study, our aim was to check for a possible independent role of hypertension in increasing the risk of developing Bell's palsy. METHODS:All patients diagnosed as having Bell's palsy referred to a neurology clinic were enrolled as cases. Controls were selected among other patients ref...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000151701
更新日期:2008-01-01 00:00:00
abstract::Don Quixote de la Mancha, which is considered one of the most important and influential works of Western modern prose, contains many references of interest for almost all of the medical specialties. In this regard, numerous references to neurology can be found in Cervantes' immortal work. In this study, we aimed to re...
journal_title:European neurology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000341338
更新日期:2012-01-01 00:00:00