Dilemma in the treatment of Parkinson's disease with L-dopa.

Abstract:

:L-Dopa pioneered the symptomatic therapy of Parkinson's disease. While this treatment proved effective in the treatment of parkinsonian akinesia, rigidity and tremor, prolonged L-dopa treatment was often noted to result in dyskinesia, psychosis and 'on-off' phenomena. This increasing disability of L-Dopa-treated parkinsonian patients, however, is not correlated with the duration of L-dopa treatment. Mortality due to Parkinson's disease has decreased significantly after the introduction of L-dopa treatment. The development of D1-selective dopamine agonists and the introduction of neuroprotective rather than symptomatic therapy are required for treating Parkinson's disease.

journal_name

Eur Neurol

journal_title

European neurology

authors

Kuno S

doi

10.1159/000119537

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

17-9

eissn

0014-3022

issn

1421-9913

journal_volume

34 Suppl 3

pub_type

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