Abstract:
:The binding of the dopamine uptake inhibitor [3H]GBR-12935 to postmortem putamen from a control group and patients with Alzheimer's disease/senile dementia of Alzheimer type (AD/SDAT) or vascular dementia (VD) was studied. The binding density (Bmax) in AD/SDAT was significantly reduced to 50% of control. A reduction of Bmax in VD was also noted, but it did not reach statistical significance. No differences in apparent binding affinity (Kd) between controls and dementia groups were obtained. The concentrations of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), 3-methoxytyramine (3-MT) and homovanillic acid were also determined. The concentrations of DA and DOPAC were reduced by 30-40% in AD/SDAT and VD, but the reductions did not reach statistical significance. The concentration of 3-MT was reduced by 40% in AD/SDAT and by 30% in VD. The [3H]GBR-12935-binding densities correlated significantly with corresponding concentrations of DA in control brains. It is suggested that the loss of [3H]GBR-12935-binding sites in human putamen in AD/SDAT reflects a degeneration of dopamine neurites.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Allard P,Alafuzoff I,Carlsson A,Eriksson K,Ericson E,Gottfries CG,Marcusson JOdoi
10.1159/000117341subject
Has Abstractpub_date
1990-01-01 00:00:00pages
181-5issue
4eissn
0014-3022issn
1421-9913journal_volume
30pub_type
杂志文章abstract::3 out of 24 patients with mitral valve prolapse (MVP), mean age 25.7 +/- 3.1 displayed markedly thickened redundant and shaggy mitral leaflets in the two-dimensional echocardiogram. The anterior leaflet appeared in the parasternal long axis plane club-shaped in diastole. These three female patients had a history of is...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115766
更新日期:1985-01-01 00:00:00
abstract::A 16-year-old patient presenting with complex partial seizures occurring in the transition from a REM period to wakefulness is described. His baseline EEG showed generalized and symmetrical slow spike and wave complexes, on a normal background activity, activated by NREM sleep. Polygraphic and videotape recordings, ca...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116383
更新日期:1989-01-01 00:00:00
abstract::The association of anaemia and gastro-intestinal abnormalities with disorders of the brain, spinal cord, and peripheral nerves has been recognized since the mid 19th century. In early reports interpretable as subacute combined degeneration, anaemia was overlooked, and conversely in Addison's and other early reports of...
journal_title:European neurology
pub_type: 历史文章,杂志文章
doi:10.1159/000131715
更新日期:2008-01-01 00:00:00
abstract::Clinicopathological data of a woman with a 3-year course of concurrent amyotrophic lateral sclerosis and dementia are presented. Dementia had occurred at time of onset of motor disturbances and presented as typical frontal lobe dementia. Pathology confirmed motor neuron disease of amyotrophic lateral sclerosis and fro...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000116962
更新日期:1993-01-01 00:00:00
abstract::The effects of biologically active light (BL) on subjective and objective quality of sleep and awakening, as well as circadian rhythms in cortisol, temperature and well-being were studied in 10 hospitalized normal female volunteers as compared with partial sleep deprivation (PSD). After 2 adaption days, three 24-hour ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116088
更新日期:1986-01-01 00:00:00
abstract::Two cases of malignant tumours of the nerve sheaths are reported. In the first patient, who had von Recklinghausen's disease, light- and electron-microscopic investigations showed an undifferentiated mesenchymal tumour of the radial nerve with the property of producing collagen fibres, an aspect characteristic of sarc...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114873
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:The meningitides are rare but well-identified complications in patients with systemic lupus erythematosus (SLE). AIMS:To determine the clinical characteristics, risk factors, prevalence and outcomes of the meningitides (septic and aseptic) in patients with SLE. PATIENTS AND METHODS:From January 1988 to Dec...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000186504
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. METHODS:We pre...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000101287
更新日期:2007-01-01 00:00:00
abstract::Machado-Joseph disease (MJD) is a dominantly inherited cerebellar ataxia associated with spasticity, ophthalmoplegia, dystonia and peripheral neuropathy. Presented here are 5 MJD cases. A morphometric analysis of the histopathology of their sural nerves was carried out to know the relationship between axon size and my...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000066169
更新日期:2002-01-01 00:00:00
abstract::Acid phosphatase staining is performed on cerebrospinal fluid cells of 365 samples from 105 patients with various types of meningitis. This enzyme activity is strongly positive in the early samples of bacterial meningitis, as far as the patients had not received a pretreatment with antibiotics for more than 24 h. It a...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116035
更新日期:1986-01-01 00:00:00
abstract::The present report evaluates the suppression of antiepileptic drugs in a group of 608 epileptics. Conditions for the suppression of antiepileptic treatment included a previous seizure-free period of 5 years under medication, and a careful evaluation of individual social and work-related circumstances. The reduction of...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116141
更新日期:1987-01-01 00:00:00
abstract::The present paper is a study of a microcystic intraspinal tumour that developed in a 4-year-old child. The histologic examination showed the presence of neuroblastic elements developing next to smooth muscle fibers. The tumour had diffusely invaded the meninges, presenting a marked collagen reaction. Ultrastructurally...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114682
更新日期:1975-01-01 00:00:00
abstract::QTc intervals were measured in 30 patients with Parkinson's disease and 30 healthy control subjects. The mean value of QTc intervals in patients with Parkinson's disease significantly exceeded that of healthy controls (418 +/- 14 ms vs. 403 +/- 18 ms). Prolongation of the QTc interval was unrelated to the administrati...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117432
更新日期:1997-01-01 00:00:00
abstract::We examined a 29-year-old woman who had language disturbances and memory impairment after a left thalamic infarction. MRI showed injury that was limited to the tuberothalamic artery territory. Beside reduced voice volume and verbal memory trouble, she presented with aspontaneity, loss of psychic self-activation and af...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116930
更新日期:1993-01-01 00:00:00
abstract::A woman who had spontaneous pain, hyperpathia and wasting of her left hand due to a subcortical lesion in the right parietal lobe is reported. The presentation and evaluation of this most unusual case are discussed. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115753
更新日期:1985-01-01 00:00:00
abstract::A double-blind controlled trial was performed on 6 patients affected with Steinert's disease in order to evaluate the efficacy of two different dosages of diphenylhydantoin (PHT, 200 and 300 mg/day) and carbamazepine (CBZ, 600 and 800 mg/day) on the myotonic afterdischarge. Both dosages of PHT and CBZ induced a signif...
journal_title:European neurology
pub_type: 临床试验,杂志文章
doi:10.1159/000115546
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND/AIMS:Behavioral and psychological symptoms of dementia (BPSD) affect almost all people with dementia at some stage during the progression of disease. The current study aimed at replicating previous findings on BPSD clustering in behavioral sub-syndromes. METHODS:One hundred and sixty-six consecutive outpati...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000341956
更新日期:2013-01-01 00:00:00
abstract::Four patients who experienced isolated transient global amnesia had computed tomographic evidence for a cerebral infarct (3 cases) or hemorrhage (1 case). The medial part of the temporal lobe was involved in 2 patients (left in 1, right in 1), the left lentiform nucleus in 1 patient, and the left thalamus in 1 left-ha...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116240
更新日期:1988-01-01 00:00:00
abstract::The serum concentration of S-100B is reported to reflect the severity of brain damage. The purpose of this study was to determine whether elevated serum S-100B concentrations were related to neuropsychological test performance of patients in the subacute phase of recovery from mild traumatic brain injury (TBI). S-100B...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000083678
更新日期:2005-01-01 00:00:00
abstract::Don Quixote de la Mancha, which is considered one of the most important and influential works of Western modern prose, contains many references of interest for almost all of the medical specialties. In this regard, numerous references to neurology can be found in Cervantes' immortal work. In this study, we aimed to re...
journal_title:European neurology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000341338
更新日期:2012-01-01 00:00:00
abstract::Nerve conduction of single impulses and the ability to transmit frequent trains of stimuli were studied in sensory median and in sural nerves of controls and patients with diabetes mellitus. Decrease of relative amplitudes and increase of relative latencies were more marked in the diabetics as compared with normal con...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115123
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Transient ischemic attacks (TIAs) bear a presumed high risk of early recurrence of stroke. Data in the literature, however, are inconsistent, as recurrence rates range from 9.5 to 20%, at 90 days. AIMS:The study was designed to determine the risk of stroke after TIA. METHODS:94 consecutive patients referre...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000332999
更新日期:2012-01-01 00:00:00
abstract::Many gadolinium-enhanced magnetic resonance imaging (MRI) studies focusing on the anatomy and pathology of the 7th cranial nerve have already been published. However, only scattered cases of herpes zoster oticus (HZO) have been described and only the MRI appearance of the soft temporal bone structures has been reporte...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000007900
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Small fiber neuropathy (SFN) is a challenging subtype of peripheral neuropathies. Once the diagnosis has been established, there is an uncertainty how SFN may progress, whether larger fibers will become involved over time, whether quality of life may be compromised, or whether repeated diagnostic workup in p...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000487717
更新日期:2018-01-01 00:00:00
abstract::In the last 2 years we have systematically treated 31 sleep apnea patients with 25-50 mg imipramine HCl given 30 min before bedtime. Imipramine treatment was attempted for nonoverweight patients with negative ear, nose and throat (ENT) findings and for patients who had not responded to weight reduction or ENT surgery ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115991
更新日期:1986-01-01 00:00:00
abstract::We report a patient who showed exaggerated responses to external cues (utilization behavior), motor impersistence, and a right-hand-predominant instinctive grasp reaction after right thalamic infarction. High-resolution computed tomography with stereotaxic lesion localization revealed almost complete destruction of th...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117092
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to observe the incidence of falls in Parkinson's disease (PD) patients with different cognitive levels and to investigate the effect of the cholinesterase inhibitor Rivastigmine on cognitive dysfunction and falling in PD patients. SUBJECTS AND METHODS:Data from 176 PD patients ...
journal_title:European neurology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000438824
更新日期:2015-01-01 00:00:00
abstract::The effect of dosage schedules on plasma drug levels was evaluated in two groups of ambulant epileptic patients, whose treatment with diphenylhydantoin (DPH) or phenobarbital (PB) had been simplified by reducing the daily frequency of the dosage regimens. Although the patients received the same milligram per kilogram ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115099
更新日期:1979-01-01 00:00:00
abstract::Previous findings regarding the role of TNF-alpha-308 gene polymorphism in multiple sclerosis (MS) are contradictory. The aim of this study was to investigate the possible influence of TNF-alpha-308 polymorphism on MS susceptibility and the MS disease process in a Croatian and Slovenian population. Genotyping was perf...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000099159
更新日期:2007-01-01 00:00:00
abstract::Two cases of lithium neurotoxic effects are reported. Both cases are expressed by choreoathetotic movements and in both of them intoxication was caused by combined drug therapy. In our opinion caution is advised when lithium is administered in combination with drugs, especially in elderly patients. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116044
更新日期:1986-01-01 00:00:00