Prolongation of QTc interval in patients with Parkinson's disease.

Abstract:

:QTc intervals were measured in 30 patients with Parkinson's disease and 30 healthy control subjects. The mean value of QTc intervals in patients with Parkinson's disease significantly exceeded that of healthy controls (418 +/- 14 ms vs. 403 +/- 18 ms). Prolongation of the QTc interval was unrelated to the administration of levodopa. The mean QTc interval in patients whose Hoehn and Yahr score was III or more was significantly greater than that of patients whose score was II or less (424 +/- 12 ms vs. 410 +/- 12 ms). A significant correlation between the QTc interval and the Valsalva ratio, as well as the overshoot, was identified. The QTc interval is closely related to autonomic nervous system dysfunction, including abnormal baroreceptor reflex function, in patients with Parkinson's disease.

journal_name

Eur Neurol

journal_title

European neurology

authors

Oka H,Mochio S,Sato H,Katayama K

doi

10.1159/000117432

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

186-9

issue

3

eissn

0014-3022

issn

1421-9913

journal_volume

37

pub_type

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