Increased visual impairment after exercise (Uhthoff's phenomenon) in multiple sclerosis: therapeutic possibilities.

Abstract:

:The Uhthoff symptom, a transient impairment of visual function after exercise, is demonstrated in 2 multiple sclerosis patients. Following exercise, impairment of visual function, as documented most clearly by the testing of contrast sensitivity, was less obvious after body surface cooling and after treatment with orally administered 4-aminopyridine. It is hypothesized that both treatment modalities improve the nerve conduction safety factor and thereby prevent the occurrence of a conduction block, which is believed to be the mechanism underlying the Uhthoff symptom.

journal_name

Eur Neurol

journal_title

European neurology

authors

van Diemen HA,van Dongen MM,Dammers JW,Polman CH

doi

10.1159/000116830

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

231-4

issue

4

eissn

0014-3022

issn

1421-9913

journal_volume

32

pub_type

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