Correlation between estrophilin immunoreactivity and androgen receptor-binding activity in meningiomas.

Abstract:

:Estrogen receptor (ER) analysis was performed with an enzyme immunoassay using monoclonal antibodies against human ER protein (estrophilin) in 70 meningiomas. [3H]methyltrienolone, a synthetic androgen, was used for concurrent determination of the androgen receptor (AR)-binding activity. Low levels of ER immunoreactivity were detected in 36 cases (51%), whereas moderately high AR-binding activity was demonstrated in 33 (47%) tumors. A positive correlation between ER immunoreactivity and AR-binding activity is indicative for an estrogen regulation of AR via the ER system. The presence of gonadal steroid receptors in a large proportion of meningiomas and the tendency for a dependence of receptor concentrations on the histological subtype could have implications for tumor therapy.

journal_name

Eur Neurol

journal_title

European neurology

authors

Lesch KP,Schott W,Engl HG,Gross S

doi

10.1159/000116345

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

252-7

issue

4

eissn

0014-3022

issn

1421-9913

journal_volume

26

pub_type

杂志文章
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    doi:10.1159/000116076

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    authors: Lipton RB,Krupp L,Horoupian D,Hershkovitz S,Arezzo JC,Kurtzberg D

    更新日期:1988-01-01 00:00:00

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    更新日期:2009-01-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1159/000114697

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    更新日期:1975-01-01 00:00:00

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    journal_title:European neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    pub_type: 杂志文章

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    更新日期:2010-01-01 00:00:00

  • Preliminary experience with Madopar HBS: clinical observations and plasma levodopa concentrations.

    abstract::The therapeutic efficacy of Madopar HBS was investigated in 5 patients with advanced parkinsonism. They were under treatment with standard Madopar and suffered from marked fluctuations, mainly end-of-dose akinesia. All patients were abruptly switched from standard Madopar to the HBS formulation. For the first few days...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000116198

    authors: Fischer PA,Baas H

    更新日期:1987-01-01 00:00:00

  • Rate of cerebral embolic events in relation to antibiotic and anticoagulant therapy in patients with bacterial endocarditis.

    abstract::To quantitate embolic risk we studied a retrospective series of 61 patients with strictly defined bacterial endocarditis. Eighteen patients had neurological complications attributable to cerebral embolism. Seventeen embolic episodes occurred prior to antibiotic treatment and 8 episodes after its commencement. The rate...

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    pub_type: 杂志文章

    doi:10.1159/000117317

    authors: Paschalis C,Pugsley W,John R,Harrison MJ

    更新日期:1990-01-01 00:00:00

  • Observations on the blink reflex.

    abstract::The blink reflex and its equivalent glabella tap reflex are behavioural motor responses normally found in neonates and in the physiological startle reflex. Historically, it was described by Overend in 1896 and soon afterwards by McCarthy and by Bekhterev who disputed its origins. Kugelberg in 1952 recorded the early-l...

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    pub_type: 历史文章,杂志文章,评审

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    更新日期:2008-01-01 00:00:00

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    journal_title:European neurology

    pub_type: 杂志文章

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    authors: Schweikert K,Fuhr P,Probst A,Tolnay M,Renaud S,Steck AJ

    更新日期:2007-01-01 00:00:00

  • Executive and Attentional Disorders, Epilepsy and Porencephalic Cyst in Autosomal Recessive Cerebellar Ataxia Type 3 Due to ANO10 Mutation.

    abstract:BACKGROUND:ANO10 mutations have recently been reported in autosomal recessive cerebellar ataxia type 3 (ARCA3). The objective of this study was to describe the phenotype of 2 siblings with compound heterozygous ANO10 mutations and progressive cerebellar ataxia, epilepsy, and cognitive impairment. A porencephalic cyst w...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000445109

    authors: Chamard L,Sylvestre G,Koenig M,Magnin E

    更新日期:2016-01-01 00:00:00

  • Dystypia: isolated typing impairment without aphasia, apraxia or visuospatial impairment.

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    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000047971

    authors: Otsuki M,Soma Y,Arihiro S,Watanabe Y,Moriwaki H,Naritomi H

    更新日期:2002-01-01 00:00:00

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    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114824

    authors: Schmutz M,von Hahn HP,Honegger CG

    更新日期:1977-01-01 00:00:00

  • Very Early Neurophysiological Study in Guillain-Barre Syndrome.

    abstract:PURPOSE:The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report the neurophysiological abnormalities in GBS within 4 days of clinical onset. We expected that GBS will be diagnosed by the assistance of neurophysiological study in the very early stage. METHODS:We ...

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    authors: Jin J,Hu F,Qin X,Liu X,Li M,Dang Y,Dang J

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  • Wernicke's disease. A catamnestic study of 50 patients.

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    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114797

    authors: Groen RH,Hoff HC

    更新日期:1977-01-01 00:00:00

  • Current clinical spectrum of neurosyphilis in immunocompetent patients.

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    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000079391

    authors: Conde-Sendín MA,Amela-Peris R,Aladro-Benito Y,Maroto AA

    更新日期:2004-01-01 00:00:00

  • Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study.

    abstract::Experimental results suggested a modulation or 'programming' interaction of delta sleep-inducing peptide (DSIP) with endogenous opioid-peptidergic systems and exogenous intracerebrally or systemically administered morphine and amphetamine. The induction of cerebral MAO-A activity, a pronounced influence on the circadi...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115716

    authors: Larbig W,Gerber WD,Kluck M,Schoenenberger GA

    更新日期:1984-01-01 00:00:00

  • Corpus callosum atrophy--a simple predictor of multiple sclerosis progression: a longitudinal 9-year study.

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    pub_type: 杂志文章

    doi:10.1159/000337683

    authors: Vaneckova M,Kalincik T,Krasensky J,Horakova D,Havrdova E,Hrebikova T,Seidl Z

    更新日期:2012-01-01 00:00:00

  • Association between renal function and clinical outcome in patients with acute stroke.

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    pub_type: 杂志文章

    doi:10.1159/000285165

    authors: Hao Z,Wu B,Lin S,Kong FY,Tao WD,Wang DR,Liu M

    更新日期:2010-01-01 00:00:00

  • Low doses of insulin as a treatment of tardive dyskinesia: conjuncture or conjecture?

    abstract::Tardive dyskinesia (TD) induced by antipsychotic drugs represents a great concern for patients and psychiatrists. Considering its pathophysiological mechanisms, there exists a convergence towards the development of postsynaptic dopaminergic hypersensitivity as a possible cause of TD. Hypersensitivity following recepto...

    journal_title:European neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000116678

    authors: Mouret J,Khomais M,Lemoine P,Sebert P

    更新日期:1991-01-01 00:00:00

  • Movement disorders associated with chronic GM2 gangliosidosis. Case report and review of the literature.

    abstract::A 24-year-old man presented with dystonia, dementia, amyotrophy, choreoathetosis, and ataxia. Partial hexosaminidase A deficiency was documented in serum and leukocytes and confirmed by rectal biopsy with ganglion cells containing membranous cytoplasmic bodies. A brief review of the literature reveals that tremor, dys...

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    pub_type: 杂志文章

    doi:10.1159/000116100

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    更新日期:1986-01-01 00:00:00

  • Blood Pressure Variability in Acute Ischemic Stroke: Influence of Infarct Location in the Insular Cortex.

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    更新日期:2001-01-01 00:00:00