Abstract:
AIM:To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis. METHODS:In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after treatment initiation. Non-parametric and multiple regression models were built to identify the most reliable predictors of disability and of its changes over 9 years. RESULTS:Corpus callosum atrophy during the first year of treatment was the best predictor of disability (r = -0.56) and of its increase at 9 years (r = 0.65). Corpus callosum atrophy of at least 2% predicted increase in disability with 93% sensitivity and 73% specificity (odds ratio = 35). CONCLUSION:Corpus callosum atrophy is a simple and accurate predictor of future disability accumulation and is feasible for routine clinical practice.
journal_name
Eur Neuroljournal_title
European neurologyauthors
Vaneckova M,Kalincik T,Krasensky J,Horakova D,Havrdova E,Hrebikova T,Seidl Zdoi
10.1159/000337683subject
Has Abstractpub_date
2012-01-01 00:00:00pages
23-7issue
1eissn
0014-3022issn
1421-9913pii
000337683journal_volume
68pub_type
杂志文章abstract::To elucidate the clinical characteristics of aged patients with Becker muscular dystrophy (BMD), 4 patients with this disease who were over 50 years were examined. The ages at onset in all patients were later than 30 years. All were proven to have a deletion around exons 45-55 of the Duchenne muscular dystrophy (DMD) ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008089
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:It is generally assumed that silent brain infarction (SBI) and symptomatic lacunar infarction (sLAC) share common vascular risk factors and their pathogeneses are known to be similar. However, few studies have conducted a risk factor profile analysis of the two diseases in a single study design. METHOD...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000324335
更新日期:2011-01-01 00:00:00
abstract::A case of post-convulsive spinal spidural haematoma in a patient with ankylosing spondylitis is presented. As acute tetraplegia developed, surgery was performed with finding of blood clots in the extradural space from C6 to D8. Lethal evolution due to late referral to medical care stresses the need for prompt decompre...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115081
更新日期:1979-01-01 00:00:00
abstract:AIM:To determine the association between interleukin-6 (IL-6) and soluble E-selectin (sE-selectin) levels with the electrodiagnostic abnormalities in patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). METHODS:Serum HbA1c, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), f...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000444661
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Effective management of multisymptomatic chronic diseases such as multiple sclerosis (MS) requires a multimodal, interdisciplinary approach. At MS clinics, numerous healthcare specialties are coordinated to provide patients with quality clinical care for all aspects of their disease. Settings and resource av...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000367620
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although ataxic hemiparesis is a common lacunar syndrome, the precise mechanism underlying hemiataxia is not clear. We attempted to identify ataxia-related, cerebral blood flow changes in patients presenting with ataxic hemiparesis after acute capsular infarct. METHODS:We used 99mTc-ECD brain pe...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000369009
更新日期:2015-01-01 00:00:00
abstract::In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000242010
更新日期:2009-01-01 00:00:00
abstract::In 167 patients with cerebrovascular disorders 323 carotid bifurcations were investigated by Duplex ultrasound. In 100 of these patients, additionally intravenous digital subtraction angiography (DSA) was performed and in 35 patients, also intra-arterial DSA was carried out. In 32 patients all three procedures were pe...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116233
更新日期:1988-01-01 00:00:00
abstract::4 cases with an identical neuromuscular disorder are presented. The disorder was characterized by slowly progressive weakness and wasting of the proximal muscles together with either ocular or bulbar symptoms, fatigability, positive tensilon test, myasthenic response on repetitive nerve stimulations, elevated serum cr...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115454
更新日期:1982-01-01 00:00:00
abstract::Anticonvulsant therapy was stopped in 191 epileptic children (109 males and 82 females) after a seizure-free period of at least 2 years, independent of EEG findings, followed up for a minimum of 2 years after withdrawal. Overall, 43 (22.5%) had recurrence of seizures; of these, 79% relapsed within the 1st year after d...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116811
更新日期:1992-01-01 00:00:00
abstract::Sixteen children with definite multiple sclerosis (MS; aged 6-17 years, mean 11.4 +/- 2.7; 8 boys, 8 girls) were reviewed. Cerebellar symptoms and signs were frequent at initial presentation. Among laboratory studies, the cerebrospinal fluid (CSF) IgG index or oligoclonal bands were informative in 75%, evoked potentia...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000117213
更新日期:1996-01-01 00:00:00
abstract::An analysis is presented of 35 cases of chorea as a symptom of polycythaemia. This analysis reveals: (a) whereas polycythaemia occurs predominantly in males (3:2), polycythaemic chorea (PC) occurs predominantly in females (5:2), at a real ratio of female:male = 4:1, the prevalence being 1-2.5% of polycythaemic patient...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000115674
更新日期:1984-01-01 00:00:00
abstract::The cerebral hemispheres show prominent involvement in hypertensive encephalopathy far more frequently than the brainstem. Two patients with severe paroxysmally accelerated hypertension associated with brainstem hyperintensity in T2-weighted magnetic resonance images are presented. Both present hyperintense lesions im...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000100015
更新日期:2007-01-01 00:00:00
abstract::Positron emission tomography (PET) has opened new fields of investigation on clinicometabolic correlations in subcortical infarcts. Functional changes occurring in structurally unaffected brain regions represent one of the most interesting aspects of PET application. So far, the only one PET study on lacunar infarcts ...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000116466
更新日期:1989-01-01 00:00:00
abstract::Kearns-Sayre syndrome has been associated with large heteroplasmic mitochondrial DNA deletions and morphological alterations at the cytological level. We have measured the activities of different respiratory chain complexes in 3 patients presenting mitochondrial DNA deletions and found no close correlation between gen...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116656
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. METHODS:We pre...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000101287
更新日期:2007-01-01 00:00:00
abstract::We present a long-term follow-up examination concerning patients with isolated extra-ocular muscle involvement in thyroid-related orbitopathy. Within the previous 13 years we observed 7 patients with endocrine orbitopathy and marked myopathy of the extra-ocular muscles. Five of these patients had no detectable proptos...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000131894
更新日期:2008-01-01 00:00:00
abstract::Electrophysiological findings in 10 patients with polyneuropathy and nonmalignant IgMk plasma cell dyscrasia are reported. The amplitude of sensory action potentials and maximum conduction velocity along the sural and median nerves are related to the structural changes found at the biopsy and to the immunologic result...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115979
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:We aimed at measuring the positive predictive value (PPV) of data in the French Hospital Medical Information Database (FHD). SUMMARY:This retrospective multicenter study included 31 hospitals from where 56 hospital stays were randomly selected among all hospitalizations for the years 2009 and 2010 with at l...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000438859
更新日期:2015-01-01 00:00:00
abstract::An HIV-positive patient presented the classical syndrome of pure alexia. Neuroradiologic investigation by computed tomography showed a ring-like lesion in the left posterior white matter. The clinical manifestations as well as the radiologic findings resolved after antiprotozoal treatment. ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116783
更新日期:1992-01-01 00:00:00
abstract::The importance of patent foramen ovale (PFO) has long been discussed in the literature in relation to different coexisting medical conditions. Many researchers focused on the occurrence of PFO in ischemic stroke patients, especially in the subgroup of young patients with a recurrent event. Unfortunately, before establ...
journal_title:European neurology
pub_type: 杂志文章,评审
doi:10.1159/000342900
更新日期:2013-01-01 00:00:00
abstract::Superior orbital fissure syndrome is a symptomatologic complex, consisting of retroorbital pain, paralysis of extraocular muscles, impairment of first trigeminal branches and frequent involvement of the optic nerve. From a review of 130 published cases including two personal observations, it appears that the clinical ...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000114876
更新日期:1977-01-01 00:00:00
abstract::64 patients on hemodialysis were investigated. The mean duration of dialysis was 43 months. In all the patients, serum aluminium levels, systolic blood pressure (averaged over a period of 6 weeks) and the EEG were investigated. Psychological testing to assess the level of intelligence (IQ) was also performed. The seru...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115500
更新日期:1982-01-01 00:00:00
abstract::Continuing the previously published clinical development of a case of adult metachromatic leukodystrophy (MLD), we now describe the terminal phase and death (at 46 years of age) of our patient. The final phase was characterized clinically by progression of generalized peripheral neuropathy, advanced extrapyramidal and...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115164
更新日期:1980-01-01 00:00:00
abstract::This study investigates the remote effects of botulinum toxin injections by examining the motor unit architecture of noninjected distant muscles. In 21 dystonia patients treated with botulinum toxin (n = 11, mean cumulative dose = 815 mU; n = 10, mean cumulative dose = 7,207 mU) and 10 control individuals, a blinded s...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000008222
更新日期:2000-01-01 00:00:00
abstract::Reviewing the angiograms of 100 patients with RIA or stroke we found intracranial lesions in 67%, extracranial lesions in 64%, and normal angiograms in 13% of the cases. Risk factors occurred more often as the angiographic lesions were more extensive. These findings confirm the importance of angiographic examination o...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115177
更新日期:1980-01-01 00:00:00
abstract::Trials of pharmacological intervention for acute stroke show several points of similarity with legal trials by jury. The relationships between sponsoring organisation and regulatory authorities and the roles of the many other participants are described. Only through a partnership can the common aim of developing impro...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000068509
更新日期:2003-01-01 00:00:00
abstract::Two cases are presented with a long clinical history of multiple sclerosis (MS) before the diagnosis of an intracranial brain tumor. In the subsequent brain autopsy, however, both cases presented a diffusely growing anaplastic astrocytoma, only, and no changes similar to MS were seen. Diffuse tumor growth was noted in...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116009
更新日期:1986-01-01 00:00:00
abstract::20 patients who had clinical symptoms and/or signs of compression of the 7th and/or 6th cervical roots were examined. Motor and sensory nerve conduction velocities, velocities in the proximal segment of the median nerve determined by measuring F-wave latencies, cervical somatosensory evoked potentials, and needle elec...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000115592
更新日期:1983-01-01 00:00:00
abstract::Acid phosphatase staining is performed on cerebrospinal fluid cells of 365 samples from 105 patients with various types of meningitis. This enzyme activity is strongly positive in the early samples of bacterial meningitis, as far as the patients had not received a pretreatment with antibiotics for more than 24 h. It a...
journal_title:European neurology
pub_type: 杂志文章
doi:10.1159/000116035
更新日期:1986-01-01 00:00:00