Corpus callosum atrophy--a simple predictor of multiple sclerosis progression: a longitudinal 9-year study.

Abstract:

AIM:To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis. METHODS:In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after treatment initiation. Non-parametric and multiple regression models were built to identify the most reliable predictors of disability and of its changes over 9 years. RESULTS:Corpus callosum atrophy during the first year of treatment was the best predictor of disability (r = -0.56) and of its increase at 9 years (r = 0.65). Corpus callosum atrophy of at least 2% predicted increase in disability with 93% sensitivity and 73% specificity (odds ratio = 35). CONCLUSION:Corpus callosum atrophy is a simple and accurate predictor of future disability accumulation and is feasible for routine clinical practice.

journal_name

Eur Neurol

journal_title

European neurology

authors

Vaneckova M,Kalincik T,Krasensky J,Horakova D,Havrdova E,Hrebikova T,Seidl Z

doi

10.1159/000337683

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

23-7

issue

1

eissn

0014-3022

issn

1421-9913

pii

000337683

journal_volume

68

pub_type

杂志文章
  • Clinical characteristics of aged Becker muscular dystrophy patients with onset after 30 years.

    abstract::To elucidate the clinical characteristics of aged patients with Becker muscular dystrophy (BMD), 4 patients with this disease who were over 50 years were examined. The ages at onset in all patients were later than 30 years. All were proven to have a deletion around exons 45-55 of the Duchenne muscular dystrophy (DMD) ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008089

    authors: Yazaki M,Yoshida K,Nakamura A,Koyama J,Nanba T,Ohori N,Ikeda S

    更新日期:1999-01-01 00:00:00

  • Different risk factor profiles between silent brain infarction and symptomatic lacunar infarction.

    abstract:BACKGROUND/AIMS:It is generally assumed that silent brain infarction (SBI) and symptomatic lacunar infarction (sLAC) share common vascular risk factors and their pathogeneses are known to be similar. However, few studies have conducted a risk factor profile analysis of the two diseases in a single study design. METHOD...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000324335

    authors: Kim MH,Moon JS,Park SY,An SA,Kim OJ,Kim NK,Oh SH

    更新日期:2011-01-01 00:00:00

  • Post-convulsive spinal epidural haematoma in ankylosing spondylitis.

    abstract::A case of post-convulsive spinal spidural haematoma in a patient with ankylosing spondylitis is presented. As acute tetraplegia developed, surgery was performed with finding of blood clots in the extradural space from C6 to D8. Lethal evolution due to late referral to medical care stresses the need for prompt decompre...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115081

    authors: Agnetti V,Monaco F,Mutani R

    更新日期:1979-01-01 00:00:00

  • Association between the Levels of IL-6, sE-Selectin and Distal Sensory Nerve Conduction Studies in Patients with Prediabetes.

    abstract:AIM:To determine the association between interleukin-6 (IL-6) and soluble E-selectin (sE-selectin) levels with the electrodiagnostic abnormalities in patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). METHODS:Serum HbA1c, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), f...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000444661

    authors: Tiftikcioglu BI,Duksal T,Bilgin S,Kose S,Zorlu Y

    更新日期:2016-01-01 00:00:00

  • Multidisciplinary management of multiple sclerosis symptoms.

    abstract:BACKGROUND:Effective management of multisymptomatic chronic diseases such as multiple sclerosis (MS) requires a multimodal, interdisciplinary approach. At MS clinics, numerous healthcare specialties are coordinated to provide patients with quality clinical care for all aspects of their disease. Settings and resource av...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000367620

    authors: Gallien P,Gich J,Sánchez-Dalmau BF,Feneberg W

    更新日期:2014-01-01 00:00:00

  • The mechanism of ipsilateral ataxia in lacunar hemiparesis: SPECT perfusion imaging.

    abstract:BACKGROUND AND PURPOSE:Although ataxic hemiparesis is a common lacunar syndrome, the precise mechanism underlying hemiataxia is not clear. We attempted to identify ataxia-related, cerebral blood flow changes in patients presenting with ataxic hemiparesis after acute capsular infarct. METHODS:We used 99mTc-ECD brain pe...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000369009

    authors: Yamamoto R,Johkura K,Nakae Y,Tanaka F

    更新日期:2015-01-01 00:00:00

  • Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia.

    abstract::In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000242010

    authors: Fancellu R,Pareyson D,Corsini E,Salsano E,Laurà M,Bernardi G,Antozzi C,Andreetta F,Colecchia M,Di Donato S,Mariotti C

    更新日期:2009-01-01 00:00:00

  • Evaluation of the carotid bifurcation by duplex ultrasound, intravenous and intra-arterial digital subtraction angiography.

    abstract::In 167 patients with cerebrovascular disorders 323 carotid bifurcations were investigated by Duplex ultrasound. In 100 of these patients, additionally intravenous digital subtraction angiography (DSA) was performed and in 35 patients, also intra-arterial DSA was carried out. In 32 patients all three procedures were pe...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116233

    authors: Boné G,Ladurner G,Karas I,Grobovschek M,Punzengruber J

    更新日期:1988-01-01 00:00:00

  • Myasthenic neuromyopathy. An unusual neuromuscular disorder.

    abstract::4 cases with an identical neuromuscular disorder are presented. The disorder was characterized by slowly progressive weakness and wasting of the proximal muscles together with either ocular or bulbar symptoms, fatigability, positive tensilon test, myasthenic response on repetitive nerve stimulations, elevated serum cr...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115454

    authors: Kinoshita M,Nakazato H,Wakata N,Satoyoshi E

    更新日期:1982-01-01 00:00:00

  • Prognosis after therapy discontinuation in children with epilepsy.

    abstract::Anticonvulsant therapy was stopped in 191 epileptic children (109 males and 82 females) after a seizure-free period of at least 2 years, independent of EEG findings, followed up for a minimum of 2 years after withdrawal. Overall, 43 (22.5%) had recurrence of seizures; of these, 79% relapsed within the 1st year after d...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116811

    authors: Mastropaolo C,Tondi M,Carboni F,Manca S,Zoroddu F

    更新日期:1992-01-01 00:00:00

  • Multiple sclerosis in childhood: report of 16 cases.

    abstract::Sixteen children with definite multiple sclerosis (MS; aged 6-17 years, mean 11.4 +/- 2.7; 8 boys, 8 girls) were reviewed. Cerebellar symptoms and signs were frequent at initial presentation. Among laboratory studies, the cerebrospinal fluid (CSF) IgG index or oligoclonal bands were informative in 75%, evoked potentia...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000117213

    authors: Selcen D,Anlar B,Renda Y

    更新日期:1996-01-01 00:00:00

  • Chorea and polycythaemia.

    abstract::An analysis is presented of 35 cases of chorea as a symptom of polycythaemia. This analysis reveals: (a) whereas polycythaemia occurs predominantly in males (3:2), polycythaemic chorea (PC) occurs predominantly in females (5:2), at a real ratio of female:male = 4:1, the prevalence being 1-2.5% of polycythaemic patient...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000115674

    authors: Bruyn GW,Padberg G

    更新日期:1984-01-01 00:00:00

  • Brainstem involvement in hypertensive encephalopathy: a report of two cases and literature review.

    abstract::The cerebral hemispheres show prominent involvement in hypertensive encephalopathy far more frequently than the brainstem. Two patients with severe paroxysmally accelerated hypertension associated with brainstem hyperintensity in T2-weighted magnetic resonance images are presented. Both present hyperintense lesions im...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000100015

    authors: Uchino M,Haga D,Nomoto J,Mito T,Kuramitsu T

    更新日期:2007-01-01 00:00:00

  • Positron emission tomography: applications in the study of lacunar infarcts.

    abstract::Positron emission tomography (PET) has opened new fields of investigation on clinicometabolic correlations in subcortical infarcts. Functional changes occurring in structurally unaffected brain regions represent one of the most interesting aspects of PET application. So far, the only one PET study on lacunar infarcts ...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000116466

    authors: Di Piero V,Lenzi GL,Fieschi C

    更新日期:1989-01-01 00:00:00

  • Histological, enzymatic and mitochondrial DNA studies in patients with Kearns-Sayre syndrome and chronic progressive external ophthalmoplegia.

    abstract::Kearns-Sayre syndrome has been associated with large heteroplasmic mitochondrial DNA deletions and morphological alterations at the cytological level. We have measured the activities of different respiratory chain complexes in 3 patients presenting mitochondrial DNA deletions and found no close correlation between gen...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116656

    authors: Reichmann H,Degoul F,Gold R,Meurers B,Ketelsen UP,Hartmann J,Marsac C,Lestienne P

    更新日期:1991-01-01 00:00:00

  • Statins provoking MELAS syndrome. A case report.

    abstract:BACKGROUND:Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. METHODS:We pre...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000101287

    authors: Thomas JE,Lee N,Thompson PD

    更新日期:2007-01-01 00:00:00

  • Pure eye muscle involvement in endocrine orbitopathy.

    abstract::We present a long-term follow-up examination concerning patients with isolated extra-ocular muscle involvement in thyroid-related orbitopathy. Within the previous 13 years we observed 7 patients with endocrine orbitopathy and marked myopathy of the extra-ocular muscles. Five of these patients had no detectable proptos...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000131894

    authors: Gerlach M,Ferbert A

    更新日期:2008-01-01 00:00:00

  • Sensory action potentials and biopsy of the sural nerve in the neuropathy of nonmalignant IgMk plasma cell dyscrasia.

    abstract::Electrophysiological findings in 10 patients with polyneuropathy and nonmalignant IgMk plasma cell dyscrasia are reported. The amplitude of sensory action potentials and maximum conduction velocity along the sural and median nerves are related to the structural changes found at the biopsy and to the immunologic result...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115979

    authors: Galassi G,Nemni R

    更新日期:1986-01-01 00:00:00

  • Positive Predictive Value of French Hospitalization Discharge Codes for Stroke and Transient Ischemic Attack.

    abstract:BACKGROUND:We aimed at measuring the positive predictive value (PPV) of data in the French Hospital Medical Information Database (FHD). SUMMARY:This retrospective multicenter study included 31 hospitals from where 56 hospital stays were randomly selected among all hospitalizations for the years 2009 and 2010 with at l...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000438859

    authors: Giroud M,Hommel M,Benzenine E,Fauconnier J,Béjot Y,Quantin C,FRESCO Study.

    更新日期:2015-01-01 00:00:00

  • Transitory alexia without agraphia in an HIV-positive patient suffering from toxoplasma encephalitis: a case report.

    abstract::An HIV-positive patient presented the classical syndrome of pure alexia. Neuroradiologic investigation by computed tomography showed a ring-like lesion in the left posterior white matter. The clinical manifestations as well as the radiologic findings resolved after antiprotozoal treatment. ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116783

    authors: Lüscher C,Horber FF

    更新日期:1992-01-01 00:00:00

  • Stroke and patent foramen ovale in young individuals.

    abstract::The importance of patent foramen ovale (PFO) has long been discussed in the literature in relation to different coexisting medical conditions. Many researchers focused on the occurrence of PFO in ischemic stroke patients, especially in the subgroup of young patients with a recurrent event. Unfortunately, before establ...

    journal_title:European neurology

    pub_type: 杂志文章,评审

    doi:10.1159/000342900

    authors: Piechowski-Jozwiak B,Bogousslavsky J

    更新日期:2013-01-01 00:00:00

  • Superior orbital fissure syndrome. Review of 130 cases.

    abstract::Superior orbital fissure syndrome is a symptomatologic complex, consisting of retroorbital pain, paralysis of extraocular muscles, impairment of first trigeminal branches and frequent involvement of the optic nerve. From a review of 130 published cases including two personal observations, it appears that the clinical ...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000114876

    authors: Lenzi GL,Fieschi C

    更新日期:1977-01-01 00:00:00

  • Neurophysiological findings and serum aluminium in dialysis encephalopathy.

    abstract::64 patients on hemodialysis were investigated. The mean duration of dialysis was 43 months. In all the patients, serum aluminium levels, systolic blood pressure (averaged over a period of 6 weeks) and the EEG were investigated. Psychological testing to assess the level of intelligence (IQ) was also performed. The seru...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115500

    authors: Ladurner G,Wawschinek O,Pogglitsch H,Petek W,Urlesberger H,Holzer H

    更新日期:1982-01-01 00:00:00

  • Adult metachromatic leukodystrophy. III. Clinical course, final stages and first biochemical results.

    abstract::Continuing the previously published clinical development of a case of adult metachromatic leukodystrophy (MLD), we now describe the terminal phase and death (at 46 years of age) of our patient. The final phase was characterized clinically by progression of generalized peripheral neuropathy, advanced extrapyramidal and...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115164

    authors: Seidel D,Heipertz R,Goebel HH,Duensing I,Pilz H

    更新日期:1980-01-01 00:00:00

  • Remote effects of chronic botulinum toxin treatment: electrophysiologic results Do not indicate subclinical remodelling of noninjected muscles.

    abstract::This study investigates the remote effects of botulinum toxin injections by examining the motor unit architecture of noninjected distant muscles. In 21 dystonia patients treated with botulinum toxin (n = 11, mean cumulative dose = 815 mU; n = 10, mean cumulative dose = 7,207 mU) and 10 control individuals, a blinded s...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000008222

    authors: Fertl E,Schnider P,Schneider B,Auff E

    更新日期:2000-01-01 00:00:00

  • Angiographical findings and risk factors in cerebral ischaemia. A retrospective study.

    abstract::Reviewing the angiograms of 100 patients with RIA or stroke we found intracranial lesions in 67%, extracranial lesions in 64%, and normal angiograms in 13% of the cases. Risk factors occurred more often as the angiographic lesions were more extensive. These findings confirm the importance of angiographic examination o...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115177

    authors: van Oudenaarden WF,Tans JT,Hoogland PH

    更新日期:1980-01-01 00:00:00

  • Stroke: trial by jury.

    abstract::Trials of pharmacological intervention for acute stroke show several points of similarity with legal trials by jury. The relationships between sponsoring organisation and regulatory authorities and the roles of the many other participants are described. Only through a partnership can the common aim of developing impro...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000068509

    authors: Lees KR

    更新日期:2003-01-01 00:00:00

  • Diagnostic problems in multiple sclerosis. Two cases with clinical diagnosis of MS showing only a diffusely growing malignant astrocytoma.

    abstract::Two cases are presented with a long clinical history of multiple sclerosis (MS) before the diagnosis of an intracranial brain tumor. In the subsequent brain autopsy, however, both cases presented a diffusely growing anaplastic astrocytoma, only, and no changes similar to MS were seen. Diffuse tumor growth was noted in...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116009

    authors: Röyttä M,Latvala M

    更新日期:1986-01-01 00:00:00

  • Observations on the application of electrophysiological methods in the diagnosis of cervical root compressions.

    abstract::20 patients who had clinical symptoms and/or signs of compression of the 7th and/or 6th cervical roots were examined. Motor and sensory nerve conduction velocities, velocities in the proximal segment of the median nerve determined by measuring F-wave latencies, cervical somatosensory evoked potentials, and needle elec...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000115592

    authors: Tackmann W,Radü EW

    更新日期:1983-01-01 00:00:00

  • Acid phosphatase activity of cerebrospinal fluid cells in bacterial and abacterial meningitis.

    abstract::Acid phosphatase staining is performed on cerebrospinal fluid cells of 365 samples from 105 patients with various types of meningitis. This enzyme activity is strongly positive in the early samples of bacterial meningitis, as far as the patients had not received a pretreatment with antibiotics for more than 24 h. It a...

    journal_title:European neurology

    pub_type: 杂志文章

    doi:10.1159/000116035

    authors: De Reuck JL,De Coster WJ,vander Eecken HM

    更新日期:1986-01-01 00:00:00